Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ashton, Faulkner"'
Autor:
Yue Gu, Elisa Avolio, Valeria V Alvino, Anita C Thomas, Andrew Herman, Poppy J Miller, Niall Sullivan, Ashton Faulkner, Paolo Madeddu
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-16 (2023)
Abstract Background Cardiac steatosis is an early yet overlooked feature of diabetic cardiomyopathy. There is no available therapy to treat this condition. Tyrosine kinase inhibitors (TKIs) are used as first or second-line therapy in different types
Externí odkaz:
https://doaj.org/article/182661119df04ef1b680839919bcac56
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/c17261ad97074183951edbd27129ac32
Publikováno v:
Vascular Biology, Vol 4, Iss 1, Pp K1-K10 (2022)
The endothelial barrier is a tightly regulated gateway in the transport of material between circulation and the tissues. Inflammatory mediators such as thrombin are able to open paracellular spaces in the endothelial monolayer to allow the extravasat
Externí odkaz:
https://doaj.org/article/9b162d7354744d7fb4279020b4f85d97
Autor:
William Cathery, Ashton Faulkner, Eva Jover, Iker Rodriguez-Arabaolaza, Anita C. Thomas, Elisa Avolio, Massimo Caputo, Paolo Madeddu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2021)
Reconstructive surgery of congenital heart disease (CHD) remains inadequate due to the inability of prosthetic grafts to match the somatic growth of pediatric patients. Functionalization of grafts with mesenchymal stem cells (MSCs) may provide a solu
Externí odkaz:
https://doaj.org/article/980fd564c2bf4aceb07a45cfb0803724
Autor:
Ashton Faulkner, Zexu Dang, Elisa Avolio, Anita C Thomas, Thomas Batstone, Gavin R Lloyd, Ralf JM Weber, Lukáš Najdekr, Andris Jankevics, Warwick B Dunn, Gaia Spinetti, Carmine Vecchione, Annibale A Puca, Paolo Madeddu
Publikováno v:
Cells, Vol 9, Iss 5, p 1283 (2020)
Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the adverse influence of diabetes on the heart, and the transfer of a longevity-associated var
Externí odkaz:
https://doaj.org/article/495f0d7e7d1c4428a86f22c442def5f6
Autor:
James A E, Lane, Ashton, Faulkner, Elizabeth J T, Finding, Eleanor G, Lynam, Caroline P D, Wheeler-Jones
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2475
Angiogenesis is essential for wound healing and regeneration and plays a significant role in several pathologies including cancer and atherosclerosis. In vitro assays offer simple and powerful tools for investigating the regulation of the angiogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4a0ffb88e3893bd8e9d3ece35d404ee
https://pubmed.ncbi.nlm.nih.gov/35451758
https://pubmed.ncbi.nlm.nih.gov/35451758
Autor:
Gaia Spinetti, Stephen J. Paisey, Ashton Faulkner, Zexu Dang, Elena Ciaglia, Aishah Alenzi, Annibale Alessandro Puca, Carmine Vecchione, Antonio D'Amato, Elisa Avolio, Albino Carrizzo, Nicoletta Finato, Paolo Madeddu, Anna Maciag, Yue Gu, Celeste Cervellin, Anita C Thomas, Antonio Paolo Beltrami
Publikováno v:
Dang, Z, Avolio, E, Thomas, A C, Faulkner, A, Gu, Y, Madeddu, P R & al., E 2020, ' Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type-2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway ', European Journal of Heart Failure, vol. 22, no. 9, pp. 1568-1581 . https://doi.org/10.1002/ejhf.1840
Aims: Homozygosity for a 4-missense single-nucleotide-polymorphism-haplotype of the human BPIFB4 gene is enriched in long-living individuals. Delivery of this Longevity Associated Variant (LAV) improved revascularisation and reduced endothelial dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e15cfb7fd2dc7350330357086ba1532
https://doi.org/10.1002/ejhf.1840
https://doi.org/10.1002/ejhf.1840
Autor:
James A. E. Lane, Ashton Faulkner, Elizabeth J. T. Finding, Eleanor G. Lynam, Caroline P. D. Wheeler-Jones
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::523ed197aa4742ae95d4149a92c99715
https://doi.org/10.1007/978-1-0716-2217-9_13
https://doi.org/10.1007/978-1-0716-2217-9_13
Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease
Autor:
Ashton Faulkner
Publikováno v:
Faulkner, A R M 2021, ' Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease ', Biochemical Society Transactions, vol. 49, no. 1, pp. 507-517 . https://doi.org/10.1042/BST20200991
The endothelium acts as a gatekeeper, controlling the movement of biomolecules between the circulation and underlying tissues. Although conditions of metabolic stress are traditionally considered as causes of endothelial dysfunction, a principal driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455d02d50c098bdeda17b5bb9f1ab3ad
https://hdl.handle.net/1983/4d141f84-71ed-4858-816e-af4e65bcb40c
https://hdl.handle.net/1983/4d141f84-71ed-4858-816e-af4e65bcb40c
Autor:
Annibale Alessandro Puca, Elisa Avolio, Carmine Vecchione, Paolo Madeddu, Zexu Dang, Anna Maciag, Anna Ferrario, Elena Ciaglia, Antonio D'Amato, Gaia Spinetti, Ashton Faulkner, Yue Gu, Anita C Thomas, Antonio Paolo Beltrami, Albino Carrizzo
Publikováno v:
Avolio, E, Thomas, A C, Dang, Z, Faulkner, A R M, Gu, Y, Beltrami, A P, Carrizzo, A, Maciag, A, Ciaglia, E, Ferrario, A, Damato, A, Spinetti, G, Vecchione, C, Puca, A A & Madeddu, P R 2020, ' Rescue of cardiac function in obese type-2 diabetic mice by transfer of a human longevity gene ', European Heart Journal, vol. 41, no. supplement 2, ehaa946.3653, pp. 3653 . https://doi.org/10.1093/ehjci/ehaa946.3653
Background Healthy longevity is the result of the interaction between favourable environment and unique genetic makeup. We showed that horizontal transfer of a longevity-associated gene variant (LAV-BPIFB4) improves endothelial function and accelerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2c1ac6c86b9139ea564dc2ccb45128
https://doi.org/10.1093/ehjci/ehaa946.3653
https://doi.org/10.1093/ehjci/ehaa946.3653