Výsledky vyhledávání - "Ashraff Makda"

A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging

Autor: Antonio Fernandez, Nicola Kielland, Ashraff Makda, Neil O. Carragher, M. Carmen González-García, Laura Espinar-Barranco, Juan A. González-Vera, Angel Orte, Rodolfo Lavilla, Marc Vendrell

Publikováno v: Fernandez, A, Kielland, N, Makda, A, Carragher, N O, González-garcía, M C, Espinar-barranco, L, González-vera, J A, Orte, A, Lavilla, R & Vendrell, M 2022, ' A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging ', RSC Chemical Biology . https://doi.org/10.1039/D2CB00168C
RSC Chemical Biology

We report a platform combining multicomponent reaction synthesis and automated cell-based screening to develop biocompatible NIR-BODIPY fluorophores. From a library of over 60 fluorophores, we optimised compound NIRBD-62c as a multimodal probe with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89657a57677aa64cae530d96ac2ce2f
https://hdl.handle.net/10481/76963

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Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes

Autor: Rebecca E. Hughes, Richard J. R. Elliott, Xiaodun Li, Alison F. Munro, Ashraff Makda, Roderick N. Carter, Nicholas M. Morton, Kenji Fujihara, Nicholas J. Clemons, Rebecca Fitzgerald, J. Robert O’Neill, Ted Hupp, Neil O. Carragher

Publikováno v: Hughes, R E, Elliott, R J R, Li, X, Munro, A F, Makda, A, Carter, R N, Morton, N M, Fujihara, K, Clemons, N J, Fitzgerald, R, O’neill, J R, Hupp, T & Carragher, N O 2022, ' Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes ', Acs chemical biology . https://doi.org/10.1021/acschembio.2c00301

Esophageal adenocarcinoma is of increasing global concern due to increasing incidence, a lack of effective treatments, and poor prognosis. Therapeutic target discovery and clinical trials have been hindered by the heterogeneity of the disease, the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ae1b81ebfac4d9ae464d548058df3c
https://hdl.handle.net/20.500.11820/912bf260-81ba-4eb2-816a-27ffa0dbfa9d

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High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery

Autor: Ashraff Makda, Alison F. Munro, J. Robert O’Neill, Rebecca E. Hughes, Richard J. R. Elliott, Ted R. Hupp, Neil O. Carragher

Publikováno v: Slas Discovery
Hughes, B, Elliott, R, Munro, A, Makda, A, O'Neill, R, Hupp, T & Carragher, N 2020, ' High Content Phenotypic Profiling in Oesophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery ', Slas Discovery . https://doi.org/10.1177/2472555220917115

Oesophageal adenocarcinoma (OAC) is a highly heterogeneous disease, dominated by large-scale genomic rearrangements and copy number alterations. Such characteristics have hampered conventional target-directed drug discovery and personalized medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d1c07508bb452b6ba2d9e3e8b7319e
https://doi.org/10.1177/2472555220917115

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