Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ashraf Wilsily"'
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
Autor:
Liang Zhang, Daniel J. Griffin, Matthew G. Beaver, Laura E. Blue, Christopher J. Borths, Derek B. Brown, Seb Caille, Ying Chen, Alan H. Cherney, Brian M. Cochran, John T. Colyer, Michael T. Corbett, Tiffany L. Correll, Richard D. Crockett, Xi-Jie Dai, Peter K. Dornan, Robert P. Farrell, Simon J. Hedley, Hsiao-Wu Hsieh, Liang Huang, Seth Huggins, Min Liu, Michael A. Lovette, Kyle Quasdorf, William Powazinik, Jonathan Reifman, Jo Anna Robinson, Rahul P. Sangodkar, Sonika Sharma, Srividya Sharvan Kumar, Austin G. Smith, Gabrielle St-Pierre, Jason S. Tedrow, Oliver R. Thiel, Jonathan V. Truong, Shawn D. Walker, Carolyn S. Wei, Ashraf Wilsily, Yong Xie, Ning Yang, Andrew T. Parsons
Publikováno v:
Organic Process Research & Development. 26:3115-3125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::972bf6936d6ce0633f15e7dda136b897
https://doi.org/10.1021/acs.oprd.2c00249
https://doi.org/10.1021/acs.oprd.2c00249
Autor:
Ashraf Wilsily, Robert Zahler, Nan Ke, Claudio Chuaqui, Michael J. Bradley, Jason J. Marineau, Goran Malojčić, Stephane Ciblat, Anneli Savinainen, Darby Schmidt, Nigel J. Waters, Kristin B. Hamman, Sydney Alnemy, Stephanie Roy, Dana K. Winter, Anzhelika Kabro, Kenneth Matthew Whitmore, Shanhu Hu, Janessa Mihalich
Publikováno v:
Journal of medicinal chemistry. 65(2)
CDK7 has emerged as an exciting target in oncology due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. This report describes the discovery of SY-5609, a highly potent (sub-nM CDK7 Kd) and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a002487d311de55b839be03137541dfe
https://pubmed.ncbi.nlm.nih.gov/34726887
https://pubmed.ncbi.nlm.nih.gov/34726887
Publikováno v:
Organic Process Research & Development. 21:1286-1293
A two-step synthesis of an intermediate for a drug-candidate, 3-fluoro-2-hydrazinyl-5-(1-methyl-1H-pyrazol-4-yl)pyridine (1), was developed and optimized according to the strategic priorities of the program. The bond disconnection remained unchanged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f9e048aeaf241c7babae8b6b2e841f1
https://doi.org/10.1021/acs.oprd.7b00172
https://doi.org/10.1021/acs.oprd.7b00172
Publikováno v:
Advanced Synthesis & Catalysis. 358:3422-3434
The modification of benzylic quaternary, tertiary, and secondary carbon centers through palladium-catalyzed hydrogenolysis of C(sp3)–C(sp3) σ bonds is presented. When benzyl Meldrum's acid derivatives bearing quaternary benzylic centers are treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a976fcc532de67df7db29c58b202c474
https://doi.org/10.1002/adsc.201600535
https://doi.org/10.1002/adsc.201600535
Publikováno v:
Synthesis. 2009:2066-2072
The asymmetric formation of all-carbon quaternary benzylic stereocenters containing a methyl substituent was realized by the enantioselective copper-catalyzed 1,4-addition of dimethylzinc to alkylidene Meldrum's acids in the presence of a chiral phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::465cfd84c41c06cf16790b0ff08fa821
https://doi.org/10.1055/s-0029-1216845
https://doi.org/10.1055/s-0029-1216845
Publikováno v:
The Journal of Organic Chemistry. 74:1259-1267
Persistent intramolecular interactions between acidic C-H hydrogens and a variety of acceptors (X) (X = O, S, Br, Cl, and F) in solution were probed by (1)H NMR experiments, using 5-benzyl Meldrum's acid derivatives. To bring about formation of intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458f82f00b7ac5062c4759d9bc4f348c
https://doi.org/10.1021/jo802311w
https://doi.org/10.1021/jo802311w
Publikováno v:
Tetrahedron: Asymmetry. 17:2957-2959
The asymmetric synthesis of tertiary and quaternary stereocentres has been successfully achieved through Cu-catalyzed 1,6-addition of dialkylzinc reagents to 5-(3-aryl-2-propenylidene) Meldrum’s acid derivatives in the presence of a phosphoramidite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793d94eedf6f3766a7ca8f5e9f09d540
https://doi.org/10.1016/j.tetasy.2006.11.009
https://doi.org/10.1016/j.tetasy.2006.11.009
Publikováno v:
ChemInform. 44
Pin the amine on the gamma: A new method has been developed for the γ-addition of nitrogen nucleophiles to γ-substituted alkynoates or allenoates through intra- and intermolecular processes that are catalyzed by spirophosphine 1 (see scheme). An as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7605448ac7d3123a5bdbda28439cec3
https://doi.org/10.1002/chin.201329070
https://doi.org/10.1002/chin.201329070
The first examples are described of catalyzed γ-additions of nitrogen nucleophiles to γ-substituted alkynoates or allenoates that proceed with good efficiency, specifically, intra- and intermolecular processes that employ distinct and useful famili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b0f4db30efb1b9f468c7651d08e43a
https://resolver.caltech.edu/CaltechAUTHORS:20130326-080903622
https://resolver.caltech.edu/CaltechAUTHORS:20130326-080903622
Publikováno v:
ChemInform. 43
Secondary alkyl bromides or chlorides bearing a carbamate, sulfonamide or sulfone group undergo nickel/chiral diamine-catalyzed alkyl—alkyl cross-coupling reactions with alkyl- or arylboranes to give the coupling products with up to 95% enantiosele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bd8681e61cc8e386f3191dc3a2c44cd
https://doi.org/10.1002/chin.201236027
https://doi.org/10.1002/chin.201236027