Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ashraf S. Al-Madhoun"'
Supplementary Methods from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a255e5d6854d16ce1d2baa2c8c2c37d4
https://doi.org/10.1158/0008-5472.22363758
https://doi.org/10.1158/0008-5472.22363758
Autor:
Ashraf S. Al-Madhoun, Mohamed Abu-Farha, Daniel Figeys, Jean-Philippe Lambert, Ilona S. Skerjanc, Fred Elisma
Publikováno v:
Molecular & Cellular Proteomics. 7:560-572
Very little is known about SET- and MYND-containing protein 2 (SMYD2), a member of the SMYD protein family. However, the interest in better understanding the roles of SMYD2 has grown because of recent reports indicating that SMYD2 methylates p53 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::739cdd7ce258ae241683da99a9af469e
https://doi.org/10.1074/mcp.m700271-mcp200
https://doi.org/10.1074/mcp.m700271-mcp200
Autor:
Yong-Xiang Chen, Edward R. O'Brien, Heidi M. McBride, Leila Haidari, Ashraf S. Al-Madhoun, Katey J. Rayner, William T. Gerthoffer
Publikováno v:
Molecular and Cellular Endocrinology. 270:33-42
Recently, we identified heat shock protein 27 (HSP27) as an estrogen receptor-beta (ERbeta) associated protein that acts as a co-repressor of estrogen signaling and serves as a biomarker of atherosclerosis. In this study, we sought to further charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48611a2417bfe49b0dd2a6534d237464
https://doi.org/10.1016/j.mce.2007.02.002
https://doi.org/10.1016/j.mce.2007.02.002
Autor:
Sharon Wilton, Christopher Ward, Alan G. Ridgeway, Christina Karamboulas, Albert Swedani, Ashraf S. Al-Madhoun, Sophie Boisvenue, Ilona S. Skerjanc
Publikováno v:
Journal of Cell Science. 119:4305-4314
Class II histone deacetylases (HDAC4, HDAC5, HDAC7 and HDAC9) have been shown to interact with myocyte enhancer factors 2 (MEF2s) and play an important role in the repression of cardiac hypertrophy. We examined the role of HDACs during the differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b9cfaabd11f529639efc2f82393c15
https://doi.org/10.1242/jcs.03185
https://doi.org/10.1242/jcs.03185
Autor:
Elena V. Usova, Guirec Y. Cosquer, Youngjoo Byun, Ashraf S. Al-Madhoun, Rohit Tiwari, Achintya K. Bandyopadhyaya, Jayaseharan Johnsamuel, Staffan Eriksson, Sureshbabu Narayanasamy, B. T. S. Thirumamagal, Werner Tjarks, Junhua Yan
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:6886-6899
Five novel 3-carboranyl thymidine analogues (3CTAs) were designed and synthesized for boron neutron capture therapy (BNCT) of cancer. Phosphorylation of all five 3CTAs was catalyzed by recombinant human thymidine kinase (hTK1) using adenosine triphos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3da9c24537a5ae3cd1d5c9ef5da254
https://doi.org/10.1016/j.bmc.2006.06.039
https://doi.org/10.1016/j.bmc.2006.06.039
Autor:
Guirec Y. Cosquer, Youngjoo Byun, Sureshbabu Narayanasamy, Staffan Eriksson, Rolf F. Barth, Ashraf S. Al-Madhoun, Werner Tjarks, Junhua Yan, B. T. S. Thirumamagal, Jayaseharan Johnsamuel
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:861-866
Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6598b1e315b76e6cbd13d71eeb9be45a
https://doi.org/10.1080/15257770600793844
https://doi.org/10.1080/15257770600793844
Autor:
Youngjoo Byun, Werner Tjarks, Sureshbabu Narayanasamy, Rohit Tiwari, Staffan Eriksson, Ashraf S. Al-Madhoun, Achintya K. Bandyopadhyaya, Rolf F. Barth, Jayaseharan Johnsamuel
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 6:127-144
One category of boron neutron capture therapy (BNCT) agents that has received extensive attention during recent years is 3-carboranyl thymidine analogues (3CTAs). These molecules are phosphorylated to the corresponding 5´- monophosphates by human th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e902a2ba7dba0cfef16fa0896a05fac
https://doi.org/10.2174/187152006776119171
https://doi.org/10.2174/187152006776119171
Autor:
Ashraf S. Al-Madhoun, Staffan Eriksson, John A. Secrist, William B. Parker, Sue C. Shaddix, John A. Montgomery, Jean‐Francois Griffon
Publikováno v:
Collection of Czechoslovak Chemical Communications. 71:1063-1087
A series of 4'-C-(hydroxymethyl) analogs of pyrimidine and purine nucleosides have been prepared utilizing standard methodologies, and the α and β anomers were separated. These analogs are part of our continuing efforts to identify new anticancer d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f8afd53705d2e42618dcbec081c5ec4
https://doi.org/10.1135/cccc20061063
https://doi.org/10.1135/cccc20061063
Autor:
Junhua Yan, Ashraf S. Al-Madhoun, Werner Tjarks, Youngjoo Byun, Jayaseharan Johnsamuel, Weilian Yang, Staffan Eriksson, Rolf F. Barth
Publikováno v:
Applied Radiation and Isotopes. 61:1125-1130
Several thymidine analogues substituted with closo- and nido-carborane at the N-3 position were synthesized. The nido-carboranyl thymidine analogues were designed to be effective substrates for human thymidine kinase 1 in combination with an increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc877ee92a341e6d24831143288436c
https://doi.org/10.1016/j.apradiso.2004.05.023
https://doi.org/10.1016/j.apradiso.2004.05.023
Autor:
Youngjoo Byun, Staffan Eriksson, Jayaseharan Johnsamuel, Nisha Lakhi, Ashraf S. Al-Madhoun, Junhua Yan, Werner Tjarks
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:4769-4781
Eleven 3-carboranyl thymidine analogues (3CTAs) containing highly hydrophilic and flexible ethyleneoxide moieties were synthesized as potential agents for boron neutron capture therapy (BNCT) and their biochemical and physicochemical properties were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f275ca0af728a0b20844d52b3cc5276
https://doi.org/10.1016/j.bmc.2004.07.032
https://doi.org/10.1016/j.bmc.2004.07.032