Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis

Autor: Mai Maher, Asmaa E. Kassab, Ashraf F. Zaher, Zeinab Mahmoud

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 532-546 (2019)

A series of novel pyrazolo[3,4-d]pyrimidines was synthesised. Twelve synthesised compounds were evaluated for their anticancer activity against 60 human tumour cell lines by NCI (USA). Compound 7d proved prominent anticancer activity. It showed 1.6-f

Externí odkaz: https://doaj.org/article/12096bd2d87e4a23b588a00d03e46241

Recent green approaches for the synthesis of pyrazolo[3,4-d]pyrimidines: A mini review

Autor: Mai Maher, Ashraf F. Zaher, Zeinab Mahmoud, Asmaa E. Kassab

Publikováno v: Archiv der PharmazieREFERENCES. 355(6)

Pyrazolo[3,4-d]pyrimidine as a bioisostere of purine has drawn considerable attention as a privileged scaffold for the design and discovery of novel drugs. Green synthesis is an emerging area in the field of chemistry that provides economic and envir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ceb00242dc3002ea95313f809d42734
https://pubmed.ncbi.nlm.nih.gov/35244962

New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies

Autor: Mona S. El-Zoghbi, Eman M. Ahmed, Nadia A. Khalil, Eman A. Sobh, Ashraf F. Zaher, Samiha A. El-Sebaey

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1839-1859 (2021)

A series of [1]benzothieno[2,3-c]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds 5a–c showed prominent growth inhibition against most cell lines. 5c was selected at five dose concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d55cc159fc1feed728dc142f5c9851

Design, Synthesis, Antitumor activity, cell cycle analysis and ELISA assay for Cyclin Dependant Kinase-2 of a new (4-aryl-6-flouro-4H-benzo[4, 5] thieno[3, 2-b] pyran) derivatives

Autor: Ashraf Mouineer, Afaf A. El-Malah, Ashraf F. Zaher, Eman A. Sobh

Publikováno v: Mediterranean Journal of Chemistry, Vol 6, Iss 5, Pp 165-179 (2017)

A series of benzo[b]thiophene and their benzo[4,5]thieno[3,2-b]pyran derivatives (3a-f), (4a-f), (5a-f) and 6 were synthesized and characterized by spectroscopic and elemental analysis. All compounds were subjected to one dose anticancer screening in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bca8f6372c3d3a7bec17badcada14d4
https://doi.org/10.13171/mjc65/01709262240-zaher

Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors

Autor: Eman M. Ahmed, Nadia A. Khalil, Mona S. El-Zoghbi, Ashraf F. Zaher, Eman A. Sobh

Publikováno v: European Journal of Medicinal Chemistry. 187:111926

A series of new benzothieno[3,2-d]pyrimidine derivatives were designed and synthesized. The National Cancer Institute (NCI, USA) evaluated all synthesized compounds against 60 human tumor cell lines. Most of the compounds showed good cytotoxicity aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438c49a6b07b412c27755ff2678139f
https://doi.org/10.1016/j.ejmech.2019.111926