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pro vyhledávání: '"Ashraf A Choglay"'
Autor:
Ashraf A Choglay, Michael E. Cheetham, J. Paul Chapple, Simon Wilkins, Christopher R. Birkett, Alexandre G. O. Rhie, Jacqueline van der Spuy
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 42:1226-1232
Conformational transitions in the prion protein (PrP) are thought to be central to the pathogenesis of the transmissible spongiform encephalopathies (TSE), such as Creutzfeldt-Jacob disease and bovine spongiform encephalopathy. Studies of prion pheno
Publikováno v:
Gene. 267(1)
We have identified a novel human cDNA with a predicted protein sequence that has 28% amino acid identity with the E. coli Hsp70 co-chaperone GrpE and designated it HMGE. Even with this low level of amino acid identity the human sequence could be effi