A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3

Autor: Harriman William Don, Heike Wulff, Yelena Bisharyan, Lore Mariën, Donna Cassidy-Hanley, Ted Clark, Yasmina Noubia Abdiche, Ellen J. Collarini, Janna Bednenko, Bas van der Woning, Paul A. Colussi, Rian Harriman, Hai M. Nguyen, Joanna Cardarelli, Hans de Haard, Alka Agrawal, Ashot Papoyan, Darlene Pedersen

Publikováno v: mAbs, vol 10, iss 4
Bednenko, J; Harriman, R; Mariën, L; Nguyen, HM; Agrawal, A; Papoyan, A; et al.(2018). A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3. mAbs, 10(4), 636-650. doi: 10.1080/19420862.2018.1445451. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7w1758ws
mAbs

© 2018 The Author(s). Taylor & Francis Group, LLC. Identifying monoclonal antibodies that block human voltage-gated ion channels (VGICs) is a challenging endeavor exacerbated by difficulties in producing recombinant ion channel proteins in amounts t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df62db04318783348336c7861780f14
https://escholarship.org/uc/item/7w1758ws

A native Zn/Cd pumping P1B ATPase from natural overexpression in a hyperaccumulator plant

Autor: Ashot Papoyan, Barbara Leitenmaier, Hendrik Küpper, Peter M. H. Kroneck, Gabriela Lutz, Mingjie Yang, Leon V. Kochian, Wolfram Welte, Aravind Parameswaran

Publikováno v: Biochemical and Biophysical Research Communications. 363:51-56

We report here the first purification of a P 1B type ATPase, a group of transporters that occurs in bacteria, plants and animals incl. humans, from a eukaryotic organism in native state. TcHMA4 is a P 1B type ATPase that is highly expressed in the Cd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179f1f7e94c62f008f894c7f09b552ab
https://doi.org/10.1016/j.bbrc.2007.08.105

Identification of Thlaspi caerulescens genes that may be involved in heavy metal hyperaccumulation and tolerance. Characterization of a novel heavy metal transporting ATPase

Autor: Leon V. Kochian, Ashot Papoyan

Publikováno v: Plant physiology. 136(3)

Thlaspi caerulescens is a heavy metal hyperaccumulator plant species that is able to accumulate extremely high levels of zinc (Zn) and cadmium (Cd) in its shoots (30,000 μg g−1 Zn and 10,000 μg g−1 Cd), and has been the subject of intense resea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c05753f16713f7631ffb2320ea81b3
https://pubmed.ncbi.nlm.nih.gov/15516513