Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma.

Autor: Choo Z; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Koh X; Experimental Drug Development Centre, A*STAR, Singapore., Wong MRE; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore., Ashokan RM; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ali Ahamed NSB; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Kang C; Experimental Drug Development Centre, A*STAR, Singapore., Kuick CH; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore., Chang KTE; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.; Duke NUS Medical School, Singapore., Larisch S; Cell Death and Cancer Research Laboratory, Department of Human Biology and Medical Sciences, University of Haifa, Haifa, Israel., Loh AHP; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.; Duke NUS Medical School, Singapore.; Cell Death and Cancer Research Laboratory, Department of Human Biology and Medical Sciences, University of Haifa, Haifa, Israel.; Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore., Chen ZX; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.; National University Cancer Institute, Singapore, National University Health System, Singapore.

Publikováno v: Cancer research communications [Cancer Res Commun] 2023 Nov 22; Vol. 3 (11), pp. 2386-2399.