Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Ashok S. Bhagwat"'
Autor:
Yasha Butt, Ramin Sakhtemani, Rukshana Mohamad-Ramshan, Michael S. Lawrence, Ashok S. Bhagwat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The APOBEC3 enzymes convert cytosines in single-stranded DNA to uracils to protect against viruses and retrotransposons but can contribute to mutations that diversify tumors. To understand the mechanism of mutagenesis, we map the uracils res
Externí odkaz:
https://doaj.org/article/820624b331134de1a53888915fff2f2b
Autor:
Adam Langenbucher, Danae Bowen, Ramin Sakhtemani, Elodie Bournique, Jillian F. Wise, Lee Zou, Ashok S. Bhagwat, Rémi Buisson, Michael S. Lawrence
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimal
Externí odkaz:
https://doaj.org/article/0df7d51a696e4dfaa11c6266dbb37d50
Autor:
Ramin Sakhtemani, Madusha L W Perera, Daniel Hübschmann, Reiner Siebert, Michael S Lawrence, Ashok S Bhagwat
Publikováno v:
Nucleic Acids Research. 50:5145-5157
Activation-induced deaminase (AID) is a DNA-cytosine deaminase that mediates maturation of antibodies through somatic hypermutation and class-switch recombination. While it causes mutations in immunoglobulin heavy and light chain genes and strand bre
Autor:
Jessica A. Stewart, Javier M. Di Noia, Amy Hin Yan Tong, Diana Nakib, Maribel Berru, Alberto Martin, Katherine Chan, Noé Seija Desivo, Gholam Ali Kardar, James R. Carlyle, Daniel Durocher, Rukshana Mohamad-Ramshan, Yuqing Feng, Jason Moffat, Madusha L. W. Perera, Rossanna C. Pezo, Alejandro Álvarez-Quilón, Philip Barbulescu, Ashok S. Bhagwat, Gavin Li, Conglei Li
Publikováno v:
Nature
Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination1,2. AID-generated deoxyuracils are recognized and proce
Publikováno v:
PLoS Genetics, Vol 14, Iss 7, p e1007516 (2018)
Recombination and mutagenesis are elevated by active transcription. The correlation between transcription and genome instability is largely explained by the topological and structural changes in DNA and the associated physical obstacles generated by
Externí odkaz:
https://doaj.org/article/85e0d7d26afc48aa8b90fb882a5aa5a4
Publikováno v:
Virology
APOBEC3 family of DNA-cytosine deaminases inactivate and mutate several human viruses. We constructed a human cell line that is inducible for EGFP-tagged APOBEC3A and found A3A predominantly in the nuclei. When these cells were infected with Herpes S
Autor:
Ashok S. Bhagwat, Ramin Sakhtemani, Vimukthi Senevirathne, Roger Pique-Regi, Jessica A. Stewart, Madusha L. W. Perera, Michael S. Lawrence
Publikováno v:
J Biol Chem
Activation-induced deaminase (AID) and apolipoprotein B mRNA-editing enzyme catalytic subunit (APOBEC) enzymes convert cytosines to uracils, creating signature mutations that have been used to predict sites targeted by these enzymes. Mutation-based t
Autor:
Jessica A, Stewart, Ashok S, Bhagwat
Publikováno v:
DNA Repair. 118:103381
Murine FAM72A, mFAM72A, binds the nuclear form of uracil-DNA glycosylase, mUNG2, inhibits its activity and causes its degradation. In immunoprecipitation assays the human paralog, hFAM72A, binds hUNG2 and is a potential anti-cancer drug target becaus
Autor:
Danae Bowen, Ashok S. Bhagwat, Ramin Sakhtemani, Michael S. Lawrence, Adam Langenbucher, Jillian F. Wise, Rémi Buisson, Elodie Bournique, Lee Zou
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
APOBEC mutagenesis, a major driver of cancer evolution, is known for targeting TpC sites in DNA. Recently, we showed that APOBEC3A (A3A) targets DNA hairpin loops. Here, we show that DNA secondary structure is in fact an orthogonal influence on A3A s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2ad5be2d6de7df9ad5881d9103ccb0
https://escholarship.org/uc/item/6hf407s2
https://escholarship.org/uc/item/6hf407s2
Autor:
Katherine Chan, Noé Seija Desivo, James R. Carlyle, Rukshana Mohamad-Ramshan, Diana Nakib, Gavin Li, Alejandro Álvarez-Quilón, Daniel Durocher, Jessica A. Stewart, Conglei Li, Maribel Berru, Philip Barbulescu, Yuqing Feng, Rossanna C. Pezo, Javier M. Di Noia, Alberto Martin, Jason Moffat, Amy Hin Yan Tong, Gholam Ali Kardar, Ashok S. Bhagwat, Madusha L. W. Perera
Activation-induced cytidine deaminase (AID) catalyzes the deamination of deoxycytidines within Immunoglobulin (Ig) genes to induce somatic hypermutation (SHM) and class switch recombination (CSR) 1,2. AID-induced deoxyuracils within Ig loci are recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a520bdfde1aa03ae4738011fcb5745b
https://doi.org/10.1101/2020.12.23.423975
https://doi.org/10.1101/2020.12.23.423975