Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ashok R. Bapat"'
Autor:
Chu-Lai Hsiao, Ramesh A. Bhat, Rayomand J Unwalla, Zhang B. Xu, Karl Malakian, William S. Somers, Tatos N. Akopian, Wah-Tung Hum, Heather A. Harris, Eric S. Manas, Michael S. Malamas, Juan C. Alvarez, Ashok R. Bapat, Scott Wolfrom, Chris P. Miller, Mark Stahl
Publikováno v:
Journal of the American Chemical Society. 126:15106-15119
We present the structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands. X-ray cocrystal structures of these ligands complexed to both ERalpha and ERbeta are described. We also discuss how molecular modeling was u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fb882810df1e98eddbab62daae6f1a
https://doi.org/10.1021/ja047633o
https://doi.org/10.1021/ja047633o
Autor:
Thomas J. Berrodin, Richard C. Winneker, Donald E. Frail, Ashok R. Bapat, Robert Powers, Dalei Shao, Diane Hauze, Eric Manas, Daniel S. Gonder
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 88:351-360
We have identified novel estrogen receptor alpha (ERalpha) antagonists using both cell-based and computer-based virtual screening strategies. A mammalian two-hybrid screen was used to select compounds that disrupt the interaction between the ERalpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b107d19637bd19d07d9957193832cf
https://doi.org/10.1016/j.jsbmb.2004.01.007
https://doi.org/10.1016/j.jsbmb.2004.01.007
Autor:
Donald E Frail, Ashok R. Bapat
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 86:143-149
The binding of ligand to a nuclear receptor causes conformational changes that can result in coactivator or corepressor recruitment and subsequent regulation of transcription. Several peptides have previously been identified that bind to the liganded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcc13c9cff5c944ab158f1eaa7edf82
https://doi.org/10.1016/s0960-0760(03)00262-0
https://doi.org/10.1016/s0960-0760(03)00262-0
Autor:
Daniel S. Gonder, Warren W. Hurlburt, Beverly Kostek, Robert Mastroeni, Murty Chengalvala, Donald E. Frail, Ashok R. Bapat
Publikováno v:
Biochemistry. 40:814-821
Rat osteo-testicular protein tyrosine phosphatase (OST-PTP), expressed in osteoblasts and testis, is a receptor-like transmembrane protein with two tandemly repeated phosphatase domains in the cytoplasmic region. In this report, we show that the firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e26de961dcf71779271c06e5f14fbfd
https://doi.org/10.1021/bi0019996
https://doi.org/10.1021/bi0019996
Publikováno v:
Steroids. 67(5)
Estrogens and selective estrogen receptor modulators are used for the treatment and prevention of conditions resulting from menopause. Since estrogens exert their activity by binding to nuclear receptors, there is intense interest in developing new l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9930907950cbb6c8a66988c4f51abf6b
https://pubmed.ncbi.nlm.nih.gov/11958794
https://pubmed.ncbi.nlm.nih.gov/11958794
Autor:
Susan L. Fitzpatrick, Judith M. Funkhouser, Istvan Merchenthaler, Ashok R. Bapat, Panayiotis E. Stevis, Donald E. Frail, Deborah M. Sindoni, Darlene C. Deecher
Publikováno v:
Endocrinology. 140(6)
Estrogen is an essential hormone for the LH surge and ovulation. The primary source of estrogen is from ovarian granulosa cells and in rats, estrogen, in turn, increases granulosa cell number and enhances FSH-stimulated gene expression in these cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecc091a6b465091e2eead86eefb1526
https://pubmed.ncbi.nlm.nih.gov/10342845
https://pubmed.ncbi.nlm.nih.gov/10342845
Autor:
Eric S. Muncert, Steven A. Bickford, Brenda L. Guzic, Barbara R. Demuth, Ashok R. Bapat, Jay B. Roberts
Publikováno v:
Telemedicine & e-Health; Jul2011, Vol. 17 Issue 6, p478-483, 6p
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 790:31-35
Thymidylate synthase was irreversibly inactivated when irradiated with ultraviolet light in the presence of 5-iodo-2′-deoxyuridylate (IdUMP). The rate of inactivation was dependent on the concentration of IdUMP. The photochemical reaction appeared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd1219dc8e7f99ac7c0a9776897d4691
https://doi.org/10.1016/0167-4838(84)90328-5
https://doi.org/10.1016/0167-4838(84)90328-5
Publikováno v:
Journal of General Virology. 68:2231-2237
It has been suggested that herpes simplex virus (HSV) type 1 may induce a virus-specific DNA topoisomerase activity which copurifies with virus-induced DNA polymerase. We have examined DNA topoisomerase (TOPO) I and II activities in HSV-2-infected He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562d97ba53d4230709510118da152fde
https://doi.org/10.1099/0022-1317-68-8-2231
https://doi.org/10.1099/0022-1317-68-8-2231
Publikováno v:
Virology. 161(1)
Herpes simplex virus type 2 (HSV-2) induces a novel ribonucleotide reductase (RR) composed of two subunits (140 and 38 kDa) in infected cells. Other investigators have developed a monoclonal antibody, A6, against the 140-kDa subunit of RR and have fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b7981f61ac8f7a6f32ef30ab059241
https://pubmed.ncbi.nlm.nih.gov/2823465
https://pubmed.ncbi.nlm.nih.gov/2823465