Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ashok P. Bidwai"'
Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles during Development
Publikováno v:
Pharmaceuticals, Vol 10, Iss 1, p 4 (2016)
CK2 is a Ser/Thr protein kinase that is highly conserved amongst all eukaryotes. It is a well-known oncogenic kinase that regulates vital cell autonomous functions and animal development. Genetic studies in the fruit fly Drosophila are providing uniq
Externí odkaz:
https://doaj.org/article/c592295583dd4e3a9aebf5789785f54a
Autor:
Ashok P. Bidwai, Lucas M. Jozwick
Publikováno v:
Molecular and Cellular Biochemistry. 478:781-790
Across metazoans, the effects of Notch signaling are mediated via the Enhancer of Split (E(spl)/HES) basic Helix-Loop-Helix-Orange (bHLH-O) repressors. Although conserved, sequence diversity is, in large part, restricted to the C-terminal domain (CtD
Autor:
Lucas M, Jozwick, Ashok P, Bidwai
Publikováno v:
Molecular and cellular biochemistry.
Across metazoan animals, the effects of Notch signaling are mediated via the Enhancer of Split (E(spl)/HES) basic Helix-Loop-Helix-Orange (bHLH-O) repressors. Although these repressors are generally conserved, their sequence diversity is, in large pa
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101884 (2014)
Drosophila Enhancer of split M8, an effector of Notch signaling, is regulated by protein kinase CK2. The phosphatase PP2A is thought to play an opposing (inhibitory) role, but the identity of the regulatory subunit was unknown. The studies described
Externí odkaz:
https://doaj.org/article/62e1dfe44f504bc4b14087407bbf4ed7
Drosophilaretinal patterning requires the expression of Atonal (Ato) through coordinated regulation of 5’ and 3’ enhancer modules.ato-3’directs initial expression of Ato which then directs autoregulation via5’-ato. Notch (N) signaling also re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd82c333421b5cbb27fea6bfca0bc4e
https://doi.org/10.1101/678169
https://doi.org/10.1101/678169
Autor:
Ashok P. Bidwai, Adam T. Majot
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186439 (2017)
PLoS ONE
PLoS ONE
Drosophila atonal (ato) is required for the specification of founding R8 photoreceptors during retinal development. ato is regulated via dual eye-specific enhancers; ato-3’ is subject to initial induction whereas 5’-ato facilitates Notch-mediated
Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles during Development
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 10, Iss 1, p 4 (2016)
Pharmaceuticals, Vol 10, Iss 1, p 4 (2016)
CK2 is a Ser/Thr protein kinase that is highly conserved amongst all eukaryotes. It is a well-known oncogenic kinase that regulates vital cell autonomous functions and animal development. Genetic studies in the fruit fly Drosophila are providing uniq
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159508 (2016)
PLoS ONE
PLoS ONE
The specification of patterned R8 photoreceptors at the onset of eye development depends on timely inhibition of Atonal (Ato) by the Enhancer of split (E(spl) repressors. Repression of Ato by E(spl)-M8 requires the kinase CK2 and is inhibited by the
Publikováno v:
genesis. 47:647-658
Repression by E(spl)M8 during inhibitory Notch (N) signaling (lateral inhibition) is regulated, in part, by protein kinase CK2, but the involvement of a phosphatase has been unclear. The studies we report here employ Tik, a unique dominant-negative (
Autor:
Ezgi Kunttas-Tatli, Pallavi P. Kuntamalla, Umesh C. Karandikar, Clifton P. Bishop, Ashok P. Bidwai
Publikováno v:
Molecular and Cellular Biochemistry. 323:49-60
CK2 is a Ser/Thr protein kinase essential for animal development. Although null alleles for CK2 are available in the mouse and Drosophila models, they are lethal when homozygous, thus necessitating conditional alleles for analysis of its developmenta