Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Ashok Litwin-Kumar"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The arthropod mushroom body is well-studied as an expansion layer representing olfactory stimuli and linking them to contingent events. However, 8% of mushroom body Kenyon cells in Drosophila melanogaster receive predominantly visual input,
Externí odkaz:
https://doaj.org/article/6a55e744b753405e948e343f64597d75
Autor:
Kaitlyn Elizabeth Ellis, Sven Bervoets, Hayley Smihula, Ishani Ganguly, Eva Vigato, Thomas O. Auer, Richard Benton, Ashok Litwin-Kumar, Sophie Jeanne Cécile Caron
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Brain evolution has primarily been studied at the macroscopic level by comparing the relative size of homologous brain centers between species. How neuronal circuits change at the cellular level over evolutionary time remains largely unanswe
Externí odkaz:
https://doaj.org/article/40dd6b606dbc4c148249ec9ac985575d
Autor:
Jack W Lindsey, Ashok Litwin-Kumar
Publikováno v:
eLife, Vol 12 (2024)
In a variety of species and behavioral contexts, learning and memory formation recruits two neural systems, with initial plasticity in one system being consolidated into the other over time. Moreover, consolidation is known to be selective; that is,
Externí odkaz:
https://doaj.org/article/dd32780b8b4d4f43998a62fe5a6cf6d3
Autor:
Kaushik J. Lakshminarasimhan, Marjorie Xie, Jeremy D. Cohen, Britton A. Sauerbrei, Adam W. Hantman, Ashok Litwin-Kumar, Sean Escola
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114059- (2024)
Summary: Thalamocortical loops have a central role in cognition and motor control, but precisely how they contribute to these processes is unclear. Recent studies showing evidence of plasticity in thalamocortical synapses indicate a role for the thal
Externí odkaz:
https://doaj.org/article/435f8ab3e4d44e5eac6aa5ce58b47b2a
Publikováno v:
eLife, Vol 12 (2023)
The cerebellar granule cell layer has inspired numerous theoretical models of neural representations that support learned behaviors, beginning with the work of Marr and Albus. In these models, granule cells form a sparse, combinatorial encoding of di
Externí odkaz:
https://doaj.org/article/a73fb784104d4403bb836071ed4410e9
Autor:
Daichi Yamada, Daniel Bushey, Feng Li, Karen L Hibbard, Megan Sammons, Jan Funke, Ashok Litwin-Kumar, Toshihide Hige, Yoshinori Aso
Publikováno v:
eLife, Vol 12 (2023)
Dopaminergic neurons with distinct projection patterns and physiological properties compose memory subsystems in a brain. However, it is poorly understood whether or how they interact during complex learning. Here, we identify a feedforward circuit f
Externí odkaz:
https://doaj.org/article/dc4b2068f5d84530a41c6f00e088dd86
Autor:
Linnie Jiang, Ashok Litwin-Kumar
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8 (2021)
The Drosophila mushroom body exhibits dopamine dependent synaptic plasticity that underlies the acquisition of associative memories. Recordings of dopamine neurons in this system have identified signals related to external reinforcement such as rewar
Externí odkaz:
https://doaj.org/article/a165b41864b84264b1f72f629526e162
Autor:
Brandon Mark, Sen-Lin Lai, Aref Arzan Zarin, Laurina Manning, Heather Q Pollington, Ashok Litwin-Kumar, Albert Cardona, James W Truman, Chris Q Doe
Publikováno v:
eLife, Vol 10 (2021)
The mechanisms specifying neuronal diversity are well characterized, yet it remains unclear how or if these mechanisms regulate neural circuit assembly. To address this, we mapped the developmental origin of 160 interneurons from seven bilateral neur
Externí odkaz:
https://doaj.org/article/7c643a9dcfe149a986542c2158e46cb8
Autor:
David Ng, Ana Pinharanda, Merly C Vogt, Ashok Litwin-Kumar, Kyle Stearns, Urvashi Thopte, Enrico Cannavo, Armen Enikolopov, Felix Fiederling, Stylianos Kosmidis, Barbara Noro, Ines Rodrigues-Vaz, Hani Shayya, Peter Andolfatto, Darcy S Peterka, Tanya Tabachnik, Jeanine D'Armiento, Monica Goldklang, Andres Bendesky
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257464 (2021)
Despite the development of effective vaccines against SARS-CoV-2, epidemiological control of the virus is still challenging due to slow vaccine rollouts, incomplete vaccine protection to current and emerging variants, and unwillingness to get vaccina
Externí odkaz:
https://doaj.org/article/40755ad4580445b78521b0b9e5301357
Autor:
Feng Li, Jack W Lindsey, Elizabeth C Marin, Nils Otto, Marisa Dreher, Georgia Dempsey, Ildiko Stark, Alexander S Bates, Markus William Pleijzier, Philipp Schlegel, Aljoscha Nern, Shin-ya Takemura, Nils Eckstein, Tansy Yang, Audrey Francis, Amalia Braun, Ruchi Parekh, Marta Costa, Louis K Scheffer, Yoshinori Aso, Gregory SXE Jefferis, Larry F Abbott, Ashok Litwin-Kumar, Scott Waddell, Gerald M Rubin
Publikováno v:
eLife, Vol 9 (2020)
Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its
Externí odkaz:
https://doaj.org/article/38a0d0540def4718b12444ab842bda3c