Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ashok Kumar Manickaraj"'
Autor:
Marie A. Chaix, James Ellis, Cedric Manlhiot, Emily Lam, Paul C. Nathan, Neha Parmar, Anne Christie, Jane Lougheed, Paul F. Kantor, Guoliang Meng, Luc Mertens, Anastasia Miron, Leonard S. Sender, Stacey Marjerrison, Shayna Zelcer, Ashok Kumar Manickaraj, David C. Hodgson, Rejane Dillenburg, Seema Mital, Oyediran Akinrinade, Herschel Rosenberg, Roderick Yao, Caroline Kinnear, Myriam Lafreniere-Roula, Mylene Bassal
Publikováno v:
Paediatrics Publications
JACC: CardioOncology
JACC: CardioOncology
Background Despite known clinical risk factors, predicting anthracycline cardiotoxicity remains challenging. Objectives This study sought to develop a clinical and genetic risk prediction model for anthracycline cardiotoxicity in childhood cancer sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9640c808872a8ac2a5f1d998b90f334
https://doi.org/10.1016/j.jaccao.2020.11.004
https://doi.org/10.1016/j.jaccao.2020.11.004
Autor:
Jane Lougheed, Paul F. Kantor, Marie A. Chaix, Rejane Dillenburg, Myriam Lafreniere-Roula, Cedric Manlhiot, Leonard S. Sender, Stacey Marjerrison, Guoliang Meng, Roderick Yao, Ashok Kumar Manickaraj, Anne Christie, Seema Mital, Paul C. Nathan, Shayna Zelcer, Luc Mertens, Mylene Bassal, Neha Parmar, David R. W. Hodgson, James Ellis, Emily Lam, Peter Liu, Oyediran Akinrinade, Herschel Rosenberg, Anastasia Miron
Publikováno v:
Circulation. 142
Background: Despite known clinical and genetic risk factors, predicting anthracycline cardiotoxicity remains challenging. Objective: To develop a risk prediction model for anthracycline cardiotoxicity in childhood cancer survivors. Methods: We perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d19ed745b1e97c6e299be80486bd3a0
https://doi.org/10.1161/circ.142.suppl_3.14410
https://doi.org/10.1161/circ.142.suppl_3.14410
Autor:
G. Manase, Kristen George, A.C. Ouellette, Seema Mital, Ashok Kumar Manickaraj, Jacob Mathew, Judith Wilson, Sarah Bowdin, Leland N. Benson, Laura Zahavich
Publikováno v:
Clinical Genetics. 93:33-40
Background For clinical genetic testing of cardiomyopathy (CMP), current guidelines do not address which gene panels to use: targeted panels specific to a CMP phenotype or expanded (panCMP) panels that include genes associated with multiple phenotypi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd033dbd3f5ce5af4c279dba62d93fcd
https://doi.org/10.1111/cge.13024
https://doi.org/10.1111/cge.13024
Autor:
Carly Ogaki, Elaine Gordon, Herschel Rosenberg, David Chitayat, Lynn Bergin, Christine Dodge, Erwin Oechslin, Seema Mital, Mina Safi, Tanya Papaz, Jennifer Breaton Kyryliuk, Catherine Chant-Gambacort, Liz Burrill, Jane Lougheed, Tapas Mondal, Laura-Lee Walter, Ashok Kumar Manickaraj, John Smythe
Publikováno v:
Pediatrics. 130:e1198-e1205
BACKGROUND: Consenting minors for genetics research and biobanking involves ethical and social challenges. We examined factors influencing participation rates in a population-based biorepository for childhood heart disease. METHODS: Individuals were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b00663625350054ffebd8651202597
https://doi.org/10.1542/peds.2012-0687
https://doi.org/10.1542/peds.2012-0687
Autor:
Caroline Kinnear, Andrew N. Redington, Seema Mital, John Smythe, Aamir Jeewa, Tapas Mondal, Jane Lougheed, Herschel Rosenberg, Cedric Manlhiot, Brian W. McCrindle, Ashok Kumar Manickaraj, Luc Mertens, Glen S. Van Arsdell
Publikováno v:
Pediatric Research. 72:407-413
Background: hypoxia-inducible factor (HIF1A) regulates the myocardial response to hypoxia and hemodynamic load. We investigated the association of variants with right-ventricular (RV) remodeling after tetralogy of Fallot (TOF) repair. Methods: childr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816128ac932ba23acce200deab6ccf53
https://doi.org/10.1038/pr.2012.95
https://doi.org/10.1038/pr.2012.95
Autor:
Ashok Kumar Manickaraj, Saeed Al Turki, Lisa C.A. D'Alessandro, Dorin Manase, Seema Mital, Matthew E. Hurles
Publikováno v:
BMC Medical Genomics
Background Given the growing use of whole-exome sequencing (WES) for clinical diagnostics of complex human disorders, we evaluated coverage of clinically relevant cardiac genes on WES and factors influencing uniformity and depth of coverage of exonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e59c04adb7a911fa22a00d0638d205
https://doi.org/10.1186/s12920-014-0067-8
https://doi.org/10.1186/s12920-014-0067-8
Autor:
Linda J. Addonizio, Jaime Alkon, Brian W. McCrindle, Seema Mital, Cedric Manlhiot, Mark K. Friedberg, Ashok Kumar Manickaraj, Caroline Kinnear, Leland N. Benson, Steven D. Colan
Publikováno v:
Pediatric research. 72(6)
Risk factors for diastolic dysfunction in hypertrophic cardiomyopathy (HCM) are poorly understood. We investigated the association of variants in hypoxia-response genes with phenotype severity in pediatric HCM.A total of 80 unrelated patients21 y and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e63e616f7043454fc250e2464606ac
https://pubmed.ncbi.nlm.nih.gov/23007030
https://pubmed.ncbi.nlm.nih.gov/23007030
Publikováno v:
Future cardiology. 8(2)
As the population of childhood heart disease survivors grows, a better understanding of the genetic underpinnings of heart disease is needed to improve diagnostics, therapeutics and outcomes. The Trans-Atlantic Research Network, GenomeHeart and The S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabf53727b219cba8f5eef285b35e5fb
https://pubmed.ncbi.nlm.nih.gov/22413975
https://pubmed.ncbi.nlm.nih.gov/22413975