Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ashok K. Jha"'
Autor:
Chandralata Bal, Masaaki Toyama, Ramakrishnamraju Samunuri, Renuka Sivasankar Pallaka, Ashok K. Jha, Seshubabu Neeladri, Masanori Baba
Publikováno v:
RSC Med Chem
Modified carbocyclic nucleosides (4a–g) constituting 7-deazapurine, 4′-methyl, exocyclic double bond and 2′,3′-hydroxy were synthesized. NOE and X-ray studies of 4c confirmed the α-configuration of 4′-methyl. The anti-HBV assay demonstrate
Publikováno v:
Journal of the Indian Chemical Society. 99:100334
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 38(6)
The need of long-term treatment for chronic HBV, emergence of drug-resistant viruses and inefficiency of currently approved therapies to eliminate covalently closed circular DNA (cccDNA), mandates identification of potent and selective inhibitors of
Autor:
Chandralata Bal, Ramakrishnamraju Samunuri, Farhana Rozy, Masaaki Toyama, Monika Yadav, Ashok K. Jha, Masanori Baba, Ashoke Sharon, Mohan Kasula
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3945-3949
The potential antiviral activity of aristeromycin type of derivatives (I) is limited by associated toxicity due to its possible 5'-O-phosphorylation and S-adenosyl-l-homocysteine hydrolase (SAHase) inhibitory activity. Aristeromycin structure has maj
Autor:
Mohan Kasula, Masanori Baba, Ashoke Sharon, Harapriya Chakravarty, Ashok K. Jha, Ramakrishnamraju Samunuri, Chandralata Bal
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 35:43-52
Carbocyclic nucleosides are considered as nucleoside mimetic having high therapeutic potentials, however diverse exploration is still limited due to their synthetic difficulties. The major challenges are associated with the preparation of new base an
Autor:
Masanori Baba, Ashok K. Jha, Harapriya Chakravarty, Ashoke Sharon, Chandralata Bal, Mohan Kasula, Ramakrishnamraju Samunuri
Publikováno v:
ChemInform. 47
Carbocyclic nucleosides are considered as nucleoside mimetic having high therapeutic potentials, however diverse exploration is still limited due to their synthetic difficulties. The major challenges are associated with the preparation of new base an
Publikováno v:
Indian Journal of Physics. 85:1309-1330
High resolution spectroscopy of doped molecules in 4He nano-droplets and clusters gives a signature of superfluidity in microscopic system, termed as microscopic superfluidity. Ro-vibrational spectrum of 4HeN-M clusters is studied with the help of so
Autor:
Ashok K. Jha, Justin G. Julander, Kie-Hoon Jung, Donald F. Smee, Jung-Ae Choi, John D. Morrey, Chung K. Chu
Publikováno v:
Antiviral Research. 86:261-267
Yellow fever virus (YFV) continues to cause outbreaks of disease in endemic areas where vaccine is underutilized. Due to the effectiveness of the vaccine, antiviral development solely for the treatment of YFV is not feasible, but antivirals that are
Autor:
Ravindra K. Rawal, Dale L. Barnard, Ashoke Sharon, Chung K. Chu, Craig W. Day, Donald F. Smee, Ashok K. Jha, Jagadeeshwar R. Rao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2601-2604
Enantiomerically pure cyclopentyl cytosine [( − )-carbodine 1 ] was synthesized from d -ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine, (±)-carbodine and ribavirin. ( − )-Carbodine 1 exhibited po
Publikováno v:
Tetrahedron. 65:9362-9367
We herein report the hitherto unknown synthesis of 3-deazacarbovir and its adenosine analogue. The major highlight in the synthesis of adenosine analogs is to use 6-N,N-diboc protected 3-deazapurines 9 and 11 for regioselective Mitsunobu coupling as