Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ashok K. Dilly"'
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-13 (2020)
Abstract Background Mucinous colon cancers (MCC) are characterized by abundant production of mucin 2 (MUC2) protein and are less sensitive to standard systemic chemotherapy. We postulated that severe/persistent endoplasmic reticulum stress (ERS) aggr
Externí odkaz:
https://doaj.org/article/3cea977c93ed4b929f91cf219f252bbf
Autor:
Lesley M. Foley, Hima Makala, Haroon A. Choudry, Robin Frederick, Ashok K. Dilly, Jianxia Guo, David L. Bartlett, Jan H. Beumer, T. Kevin Hitchens, Yong J. Lee, Brendon D. Honick, Anuleka Elapavaluru, Lora H. Rigatti, Sachin Velankar
Publikováno v:
Transl Res
Abundant intraperitoneal (IP) accumulation of extracellular mucus in patients with appendiceal mucinous carcinoma peritonei (MCP) causes compressive organ dysfunction and prevents delivery of chemotherapeutic drugs to cancer cells. We hypothesized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331cc280c5360c80d524247cf364ad52
https://pubmed.ncbi.nlm.nih.gov/33164812
https://pubmed.ncbi.nlm.nih.gov/33164812
Autor:
Xinxin Song, Haroon A. Choudry, Yong J. Lee, Yong Tae Kwon, Young Sun Lee, David L. Bartlett, Ashok K. Dilly, Dae Hee Lee
Publikováno v:
Molecular Cancer Research. 16:1077-1091
Emerging evidence demonstrates that autophagy and apoptosis are interconnected and their interplay greatly affects cell death. However, the key regulators in this crosstalk remain elusive. Therefore, the role of N-terminal arginylated BiP (R-BiP)/Bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472fb0c8f2499cc162ef6a76b1158b83
https://doi.org/10.1158/1541-7786.mcr-17-0685
https://doi.org/10.1158/1541-7786.mcr-17-0685
Autor:
Ashok K. Dilly, Yong J. Lee, Yong Tae Kwon, David L. Bartlett, Haroon A. Choudry, Xinxin Song
Publikováno v:
Molecular Cancer Research. 13:1533-1543
Colorectal peritoneal carcinomatosis (CPC) exhibits severe tumor hypoxia, leading to drug resistance and disease aggressiveness. This study demonstrates that the combination of the chemotherapeutic agent mitomycin C with the proteasome inhibitor bort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c077c6b43697519ae5264eaead3f0c4
https://doi.org/10.1158/1541-7786.mcr-15-0237
https://doi.org/10.1158/1541-7786.mcr-15-0237
Autor:
Herbert J. Zeh, Yong J. Lee, Haroon A. Choudry, Brendon D. Honick, Z S Guo, David L. Bartlett, Ashok K. Dilly
Publikováno v:
Oncotarget
// Ashok K. Dilly 1 , Brendon D. Honick 1 , Yong J. Lee 1, 2 , Zong S. Guo 1 , Herbert J. Zeh 1 , David L. Bartlett 1 and Haroon A. Choudry 1 1 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh PA 15232, USA 2 Department of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f72675e182e99eb44af6fa01301717
https://pubmed.ncbi.nlm.nih.gov/29290997
https://pubmed.ncbi.nlm.nih.gov/29290997
Autor:
Yong J. Lee, Ashok K. Dilly, David L. Bartlett, Herbert J. Zeh, Zong Sheng Guo, Haroon A. Choudry
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 169
Excessive accumulation of mucin 2 (MUC2; a gel-forming secreted mucin) protein in the peritoneal cavity is the major cause of morbidity and mortality in pseudomyxoma peritonei (PMP). Hypoxia (hypoxia-inducible factor-1α; HIF-1α) has been shown to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ac526003010b0b29b222cd3e0296a7
https://pubmed.ncbi.nlm.nih.gov/26589109
https://pubmed.ncbi.nlm.nih.gov/26589109
Publikováno v:
Cancer Research. 76:3009-3009
Introduction: Pseudomyxoma peritonei (PMP) is an indolent malignancy characterized by excessive production of Mucin 2 (MUC2; a gel-forming secreted mucin). We have previously demonstrated mucinous tumor growth inhibition in a patient-derived murine x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1be965531165673f235b6db11640000d
https://doi.org/10.1158/1538-7445.am2016-3009
https://doi.org/10.1158/1538-7445.am2016-3009
Publikováno v:
Cell Death & Disease
Peritoneal carcinomatosis (PC) is the most common secondary cancerous disease, and more effective novel regimens are needed. In this study, we identified a novel combination treatment for PC, chemotherapeutic agent mitomycin C in combination with mTO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89948884f2a20846b643ba1305189f50
https://doi.org/10.1038/cddis.2014.242
https://doi.org/10.1038/cddis.2014.242