Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Ashok K. Chopra"'
FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Antibiotic resistance poses a significant hurdle in combating global public health crises, prompting the development of novel therapeutics. Strategies to enhance the intracellular killing of mycobacteria by targeting host defense mechanisms
Externí odkaz:
https://doaj.org/article/c7677f43ed154093b5f95c52cd425b72
Autor:
Jingen Zhu, Swati Jain, Jian Sha, Himanshu Batra, Neeti Ananthaswamy, Paul B. Kilgore, Emily K. Hendrix, Yashoda M. Hosakote, Xiaorong Wu, Juan P. Olano, Adeyemi Kayode, Cristi L. Galindo, Simran Banga, Aleksandra Drelich, Vivian Tat, Chien-Te K. Tseng, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The U.S. Food and Drug Administration-authorized mRNA- and adenovirus-based SARS-CoV-2 vaccines are intramuscularly injected in two doses and effective in preventing COVID-19, but they do not induce efficient mucosal immunity or prevent vira
Externí odkaz:
https://doaj.org/article/bce3c0d8931d4e4fb22673c9a20b9eda
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract A plague vaccine with a fusion cassette of YscF, F1, and LcrV encoding genes in an adenovirus-5 vector (rAd5-YFV) is evaluated for efficacy and immune responses in mice. Two doses of the vaccine provides 100% protection when administered int
Externí odkaz:
https://doaj.org/article/5455c5fff7c646eb8ffc606303806caf
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Mice immunized with a combination of an adenovirus vector (Ad5-YFV) and live-attenuated (LMA)-based vaccines were evaluated for protective efficacy against pneumonic plague. While the Ad5-YFV vaccine harbors a fusion cassette of three genes
Externí odkaz:
https://doaj.org/article/b73b599f2dfa4a10b9b577f66d234609
Autor:
Jourdan A. Andersson, Alex G. Peniche, Cristi L. Galindo, Prapaporn Boonma, Jian Sha, Ruth Ann Luna, Tor C. Savidge, Ashok K. Chopra, Sara M. Dann
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Frequent and excessive use of antibiotics primes patients to Clostridioides difficile infection (CDI), which leads to fatal pseudomembranous colitis, with limited treatment options. In earlier reports, we used a drug repurposing strategy and
Externí odkaz:
https://doaj.org/article/5e714ff007e247f187ae4679e2689807
Autor:
B. Kim Lee Sim, Minglin Li, Manuel Osorio, Yun Wu, Tint T. Wai, Johnny W. Peterson, Eric R. James, Sumana Chakravarty, Lixin Gao, Rui Xu, Natasha KC, Richard E. Stafford, William S. Lawrence, Linsey A. Yeager, Jennifer E. Peel, Satheesh K. Sivasubramani, Ashok K. Chopra, Svetlana Filippova, Stephen L. Hoffman
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-7 (2017)
Counterterrorism: creating a safe, stable, easily stored anthrax vaccine A vaccine candidate for anthrax infection shows promise for improving preparedness for a biological attack. Bacillus anthracis, the bacterium responsible for anthrax is a top-ti
Externí odkaz:
https://doaj.org/article/e6ed55cb74e9406db34a5f3fb0bf3838
Autor:
Pan Tao, Marthandan Mahalingam, Jingen Zhu, Mahtab Moayeri, Jian Sha, William S. Lawrence, Stephen H. Leppla, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Bacillus anthracis and Yersinia pestis, the causative agents of anthrax and plague, respectively, are two of the deadliest pathogenic bacteria that have been used as biological warfare agents. Although Biothrax is a licensed vaccine against
Externí odkaz:
https://doaj.org/article/8e99a89944ec4a70998d621b245a3deb
Autor:
Jourdan A. Andersson, Jian Sha, Tatiana E. Erova, Eric C. Fitts, Duraisamy Ponnusamy, Elena V. Kozlova, Michelle L. Kirtley, Ashok K. Chopra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Earlier, we reported the identification of new virulence factors/mechanisms of Yersinia pestis using an in vivo signature-tagged mutagenesis (STM) screening approach. From this screen, the role of rbsA, which encodes an ATP-binding protein of ribose
Externí odkaz:
https://doaj.org/article/c72b2ce08a234915a020471bcb9383bd
Autor:
Pan Tao, Marthandan Mahalingam, Jingen Zhu, Mahtab Moayeri, Michelle L. Kirtley, Eric C. Fitts, Jourdan A. Andersson, William S. Lawrence, Stephen H. Leppla, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Bioterrorism remains as one of the biggest challenges to global security and public health. Since the deadly anthrax attacks of 2001 in the United States, Bacillus anthracis and Yersinia pestis, the causative agents of anthrax and plague, respectivel
Externí odkaz:
https://doaj.org/article/8a34650f189348629f8a72016ea0aada
Autor:
Eric C. Fitts, Jourdan A. Andersson, Michelle L. Kirtley, Jian Sha, Tatiana E. Erova, Sadhana Chauhan, Vladimir L. Motin, Ashok K. Chopra
Publikováno v:
mSphere, Vol 1, Iss 6 (2016)
ABSTRACT The Enterobacteriaceae family members, including the infamous Yersinia pestis, the causative agent of plague, have a highly conserved interbacterial signaling system that is mediated by the autoinducer-2 (AI-2) quorum-sensing molecule. The A
Externí odkaz:
https://doaj.org/article/f5e9bf8105cc43fc899d565a281323ec