Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Ashok K Chopra"'
Autor:
E. Diane Williamson, Paul B. Kilgore, Emily K. Hendrix, Blake H. Neil, Jian Sha, Ashok K. Chopra
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract There is a compelling demand for approved plague vaccines due to the endemicity of Yersinia pestis and its potential for pandemic spread. Whilst substantial progress has been made, we recommend that the global funding and health security sys
Externí odkaz:
https://doaj.org/article/5ddab73c31db4108a0c5c15fe84b2cc3
Autor:
Paul B. Kilgore, Jian Sha, Emily K. Hendrix, Blake H. Neil, William S. Lawrence, Jennifer E. Peel, Lauren Hittle, Joelle Woolston, Alexander Sulakvelidze, Jennifer A. Schwartz, Ashok K. Chopra
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 11 (2024)
ABSTRACT Yersinia pestis, one of the deadliest bacterial pathogens ever known, is responsible for three plague pandemics and several epidemics, with over 200 million deaths during recorded history. Due to high genomic plasticity, Y. pestis is amenabl
Externí odkaz:
https://doaj.org/article/fbed38d6bf6e45e684e5b7589c485d06
Autor:
Tatiana E Erova, Michelle L Kirtley, Erc C Fitts, Duraisamy Ponnusamy, Wallace B Baze, Jourdan A Andersson, Yingzi Cong, Bethany L Tiner, Jian Sha, Ashok K Chopra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 6 (2016)
We evaluated the extent of attenuation and immunogenicity of the ∆lppAB and ∆lppAB ∆msbB mutants of Salmonella enterica serovar Typhimurium when delivered to mice by the oral route. These mutants were deleted either for the Braun lipoprotein ge
Externí odkaz:
https://doaj.org/article/d8a91f8e569d44269027cadadf724fb6
Autor:
Jason A. Rosenzweig, Ashok K Chopra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 3 (2013)
Microbes are incessantly challenged by both biotic and abiotic stressors threatening their existence. Therefore, bacterial pathogens must possess mechanisms to successfully subvert host immune defenses as well as overcome the stress associated with h
Externí odkaz:
https://doaj.org/article/183c9a7949ce432e858af20f4d104eb7
Autor:
Jason A. Rosenzweig, Ashok K Chopra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 3 (2013)
Like other pathogenic bacteria, Yersinia and Aeromonas species have been continuously co-evolving with their respective hosts. Although the former is a bonafide human pathogen, the latter has gained notararity as an emerging disease-causing agent. In
Externí odkaz:
https://doaj.org/article/8d76cba80b924148b8b40fa3690fcfe4
Autor:
Pan Tao, Marthandan Mahalingam, Michelle L Kirtley, Christina J van Lier, Jian Sha, Linsey A Yeager, Ashok K Chopra, Venigalla B Rao
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003495 (2013)
Pneumonic plague is a highly virulent infectious disease with 100% mortality rate, and its causative organism Yersinia pestis poses a serious threat for deliberate use as a bioterror agent. Currently, there is no FDA approved vaccine against plague.
Externí odkaz:
https://doaj.org/article/538904e27fdb40aa8d1a5057c496d528
Autor:
Jingen Zhu, Swati Jain, Jian Sha, Himanshu Batra, Neeti Ananthaswamy, Paul B. Kilgore, Emily K. Hendrix, Yashoda M. Hosakote, Xiaorong Wu, Juan P. Olano, Adeyemi Kayode, Cristi L. Galindo, Simran Banga, Aleksandra Drelich, Vivian Tat, Chien-Te K. Tseng, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The U.S. Food and Drug Administration-authorized mRNA- and adenovirus-based SARS-CoV-2 vaccines are intramuscularly injected in two doses and effective in preventing COVID-19, but they do not induce efficient mucosal immunity or prevent vira
Externí odkaz:
https://doaj.org/article/bce3c0d8931d4e4fb22673c9a20b9eda
FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy
Publikováno v:
Microbiology Spectrum. 10
Antibiotic resistance poses a significant hurdle in combating global public health crises, prompting the development of novel therapeutics. Strategies to enhance the intracellular killing of mycobacteria by targeting host defense mechanisms offer num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738371f73c596b038a9d714507b61ee5
https://doi.org/10.1128/spectrum.02509-22
https://doi.org/10.1128/spectrum.02509-22
Publikováno v:
Applied Microbiology and Biotechnology
As the reality of pandemic threats challenges humanity, exemplified during the ongoing SARS-CoV-2 infections, the development of vaccines targeting these etiological agents of disease has become increasingly critical. Of paramount concern are novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ba19ba8b9cfe00d2be9faf13f8640d
https://doi.org/10.1007/s00253-021-11389-6
https://doi.org/10.1007/s00253-021-11389-6
Publikováno v:
Toxins, Vol 2, Iss 7, Pp 1881-1897 (2010)
Anthrax edema toxin (ET), a powerful adenylyl cyclase, is an important virulence factor of Bacillus anthracis. Until recently, only a modest amount of research was performed to understand the role this toxin plays in the organism’s immune evasion s
Externí odkaz:
https://doaj.org/article/ee9da1f0c7184473899f12700e462bba