Výsledky vyhledávání - "Ashok J. Chavan"

The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

Autor: Kimberly A. Fraley, David Bom, Stephen G. Zimmer, Lori J. Latus, Stefan Kruszewski, Ashok J. Chavan, Thomas G. Burke, Dennis P. Curran, Wu Du, Glenda Kohlhagen, Yves Pommier, J. Thompson Strode, Alex L. Bingcang

Publikováno v: Journal of Medicinal Chemistry. 43:3970-3980

We describe the rational design and synthesis of B- and A, B-ring-modified camptothecins. The key alpha-hydroxy-delta-lactone pharmacophore in 7-tert-butyldimethylsilyl-10-hydroxycamptothecin (DB-67, 14) displays superior stability in human blood whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02e889869eb11054d77d53d3468a763
https://doi.org/10.1021/jm000144o

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Chemical Attachment of Organic Functional Groups to Single-walled Carbon Nanotube Material

Autor: Richard E. Smalley, Elizabeth C. Dickey, Won Hee Lee, P. C. Eklund, Yongsheng Chen, E. A. Grulke, Ashok J. Chavan, Boyd E. Haley, Robert C. Haddon, S. Fang, J. C. Pendergrass, Apparao M. Rao

Publikováno v: Journal of Materials Research. 13:2423-2431

We have subjected single-walled carbon nanotube materials (SWNTM's) to a variety of organic functionalization reactions. These reactions include radioactive photolabeling studies using diradical and nitrene sources, and treatment with dichlorocarbene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2a9d64c233531063f35b4494430635a
https://doi.org/10.1557/jmr.1998.0337

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Site-specific photobiotinylation of immunoglobulins, fragments and light chain dimers

Autor: Boyd E. Haley, Carol O'Toole, Ashok J. Chavan, Krishnan Rajagopalan, Heinz Kohler, Gail Sievert, Dingyuan Lou, Gabriela Pavlinkova, Sybille Müller

Publikováno v: Journal of Immunological Methods. 201:77-88

Herein we report a new method to rapidly photoinsert biotin into a specific and highly conserved site on the Ig structure using a mild photochemical activation step. This site resides in the Fv fragment and involves invariant residues which provide b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d2c6433c1aa78dbd0b02ae84bad784
https://doi.org/10.1016/s0022-1759(96)00214-1

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Identification of N-Terminus Peptide of Human Granulocyte/Macrophage Colony-Stimulating Factor as the Site of Nucleotide Interaction

Autor: T. Boone, Ashok J. Chavan, Michael Doukas, Cecelia Gass, Boyd E. Haley

Publikováno v: Biochemical and Biophysical Research Communications. 208:390-396

The interaction of nucleotides with recombinant human granulocyte/macrophage colony stimulating factor (rhGM-CSF) has been investigated. Utilizing nucleotide photoaffinity probes [gamma 32P]-8N3ATP and [beta 32P]-8N3Ap4A, an analog of alarmone, the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baf63cfcaa922ea5f2e52b8aa87408d
https://doi.org/10.1006/bbrc.1995.1350

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Interaction of Nucleotides with Acidic Fibroblast Growth Factor (FGF-1)

Autor: Mark W. Bruner, Kimberly E. Marfia, Ashok J. Chavan, David B. Volkin, C J Burke, Boyd E. Haley, J P Draper, A M Verticelli, Middaugh Cr

Publikováno v: Biochemistry. 33:7193-7202

A wide variety of nucleotides are shown to bind to acidic fibroblast growth factor (aFGF) as demonstrated by their ability to (1) inhibit the heat-induced aggregation of the protein, (2) enhance the thermal stability of aFGF as monitored by both intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c54f7947af78b739cd9860b0d382a6
https://doi.org/10.1021/bi00189a023

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Photoaffinity labeling of human placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase with [alpha-32P]2N3NAD+. Identification of a peptide in the adenine ring binding domain

Autor: C. M. Ensor, Hsin-Hsiung Tai, Ashok J. Chavan, Ping Wu, Boyd E. Haley

Publikováno v: Journal of Biological Chemistry. 268:16437-16442

Oxidation of many prostaglandins at C-15 results in the formation of 15-keto metabolites, which have reduced biological activity. This reaction is catalyzed by NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Using the photoaffinity analog of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06c613b0c14166c0f4721544a3ae7302
https://doi.org/10.1016/s0021-9258(19)85439-x

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Synthesis and application of bidentate photoaffinity cross-linking reagents. Nucleotide photoaffinity probes with two photoactive groups

Autor: Boyd E. Haley, Ashok J. Chavan, Krishnan Rajagopalan, David S. Watt

Publikováno v: Journal of Biological Chemistry. 268:14230-14238

Two "targeted bidentate" photoaffinity cross-linking reagents, the monoanhydride of 8-N3ADP with N-(4-(benzoyl)phenylmethyl)phosphoramide ([gamma-32P]8-N3ATP gamma BP) and the monoanhydride of 8-N3GDP with N-(4-(benzoyl)phenylmethyl)-phosphoramide ([

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e395d4783f9a46b2f046178d2b6e9b4a
https://doi.org/10.1016/s0021-9258(19)85231-6

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