Výsledky vyhledávání - "Ashok G. Chaudhary"

Characterization of the Taxol Binding Site on the Microtubule

Autor: George A. Orr, Srinivasa K. Rao, Susan Band Horwitz, David G. I. Kingston, Ashok G. Chaudhary

Publikováno v: Journal of Biological Chemistry. 270:20235-20238

Photoaffinity labeling methods are being used to define the molecular contacts between taxol and its target protein, tubulin. Our laboratory has demonstrated previously that [3H]3′-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e617935b1244874f5834adf1a60b2cb
https://doi.org/10.1074/jbc.270.35.20235

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Synthesis and biological evaluation of 4-deacetoxypaclitaxel

Autor: Mahendra D. Chordia, David G. I. Kingston, Ernest Hamel, Y. Q. Jiang, Ashok G. Chaudhary

Publikováno v: Tetrahedron Letters. 35:6843-6846

4-Deacetoxypaclitaxel ( 9 ) has been prepared in seven steps from paclitaxel (Taxol ® ). It is significantly less active than paclitaxel in tubulin-assembly and cytotoxicity bioassays.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97794edd8e3ae21290da674880a57c51
https://doi.org/10.1016/0040-4039(94)85019-4

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Modified Taxols, 9. Synthesis and Biological Evaluation of 7-Substituted Photoaffinity Analogues of Taxol

Autor: John M. Rimoldi, Ernest Hamel, David G. L. Kingston, Gamini Samaranayake, Ashok G. Chaudhary, Surinder Grover

Publikováno v: Journal of Natural Products. 56:1313-1330

The 7-substituted taxol analogues 7, 19, 27, and 32 have been prepared as potential photoaffinity-labeled derivatives for studies of the nature of the binding site of taxol on polymerized tubulin. The analogue 32 has been prepared in both deuterium-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9938ed31717bfec2b42e0b6ad9b8e94
https://doi.org/10.1021/np50098a016

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Synthesis of 10-deacetoxytaxol and 10-deoxytaxotere

Autor: Ashok G. Chaudhary, David G. I. Kingston

Publikováno v: Tetrahedron Letters. 34:4921-4924

10-Deacetoxytaxol (9) and 10-deoxytaxotere (10) have been prepared from 10-deacetylbaccatin III by attachment of the C-13 side-chain and deoxygenation. 10-Deacetoxytaxol is comparable to taxol in its cytotoxicity to P-388 cells, but 10-deoxytaxotere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88c774647a537cc4eab702078ca9d081
https://doi.org/10.1016/s0040-4039(00)74046-9

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ChemInform Abstract: β-Lactam Formation via Enolate Addition: An Unexpected Methylenation Reaction

Autor: Ashok G. Chaudhary, Ajay K. Bose, Vegesna S. Raju, Maghar S. Manhas, E. W. Robb

Publikováno v: ChemInform. 24

The condensation of ethyl phenylacetate or ethyl β-hydroxybutyrate with Schiff bases in presence of an excess of lithium diisopropylamide or lithium hexamethyldisilazide leads to unsaturated amines instead of the expected β-lactams

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fff5d9d4d99906345ea8bef3905ef50
https://doi.org/10.1002/chin.199346158

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ChemInform Abstract: Synthesis and Biological Evaluation of 4-Deacetoxypaclitaxel

Autor: Ashok G. Chaudhary, David G. I. Kingston, Ernest Hamel, Mahendra D. Chordia, Y. Q. Jiang

Publikováno v: ChemInform. 26

4-Deacetoxypaclitaxel ( 9 ) has been prepared in seven steps from paclitaxel (Taxol ® ). It is significantly less active than paclitaxel in tubulin-assembly and cytotoxicity bioassays.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cde2c9efb10343a210a774590849c573
https://doi.org/10.1002/chin.199507206

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