Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Ashok B Kulkarni"'
Autor:
Naoto Haruyama, Takayoshi Yamaza, Shigeki Suzuki, Bradford Hall, Andrew Cho, Carolyn W Gibson, Ashok B Kulkarni
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259966 (2021)
Amelogenins, major extra cellular matrix proteins of developing tooth enamel, are predominantly expressed by ameloblasts and play significant roles in the formation of enamel. Recently, amelogenin has been detected in various epithelial and mesenchym
Externí odkaz:
https://doaj.org/article/1ff28034690d423d956e4f50ae60b692
Autor:
Bradford E. Hall, Khadijah Mazhar, Emma Macdonald, Margaret Cassidy, Megan Doty, Christian Judkins, Anita Terse, Stephanie Shiers, Saber Tadros, Sijung Yun, Michael D. Burton, Theodore J. Price, Ashok B. Kulkarni
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Autoimmune diseases such as rheumatoid arthritis (RA) can promote states of chronic inflammation with accompanying tissue destruction and pain. RA can cause inflammatory synovitis in peripheral joints, particularly within the hands and feet,
Externí odkaz:
https://doaj.org/article/f93cc78f997a48deb8769585b76ceaa5
Autor:
Vaishali N. Patel, Marit H. Aure, Sophie H. Choi, James R. Ball, Ethan D. Lane, Zhangjie Wang, Yongmei Xu, Changyu Zheng, Xibao Liu, Daniel Martin, Jillian Y. Pailin, Michaela Prochazkova, Ashok B. Kulkarni, Toin H. van Kuppevelt, Indu S. Ambudkar, Jian Liu, Matthew P. Hoffman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Heparan sulfate (HS) regulation of FGFR function, which is essential for salivary gland (SG) development, is determined by the immense structural diversity of sulfated HS domains. 3-O-sulfotransferases generate highly 3-O-sulfated HS domains
Externí odkaz:
https://doaj.org/article/1d729c7a230d48a69e9967ba3a35489e
Autor:
Wei-Ming Wang, Zhi-Li Zhao, Si-Rui Ma, Guang-Tao Yu, Bing Liu, Lu Zhang, Wen-Feng Zhang, Ashok B Kulkarni, Zhi-Jun Sun, Yi-Fang Zhao
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0119723 (2015)
Angiogenesis, a marker of cancer development, affects response to radiotherapy sensibility. This preclinical study aims to understand the receptor tyrosine kinase-mediated angiogenesis in head neck squamous cell carcinoma (HNSCC). The receptor tyrosi
Externí odkaz:
https://doaj.org/article/016c16bb96eb40bcb7a6d634f1cb3f46
Autor:
Erick Contreras-Vallejos, Elías Utreras, Daniel A Bórquez, Michaela Prochazkova, Anita Terse, Howard Jaffe, Andrea Toledo, Cristina Arruti, Harish C Pant, Ashok B Kulkarni, Christian González-Billault
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90363 (2014)
Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous system.
Externí odkaz:
https://doaj.org/article/4a9ed0129c7e4ab88c6261e0e03eb633
Autor:
Shigeki Suzuki, Seiji Kobuke, Naoto Haruyama, Hiroaki Hoshino, Ashok B Kulkarni, Fusanori Nishimura
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112490 (2014)
Phosphophoryn (PP) is generated from the proteolytic cleavage of dentin sialophosphoprotein (DSPP). Gene duplications in the ancestor dentin matrix protein-1 (DMP-1) genomic sequence created the DSPP gene in toothed animals. PP and DMP-1 are phosphor
Externí odkaz:
https://doaj.org/article/2dbe7b89238746fd92a144837af965ec
Autor:
Jaime Jacques, Dominique Hotton, Muriel De la Dure-Molla, Stephane Petit, Audrey Asselin, Ashok B Kulkarni, Carolyn Winters Gibson, Steven Joseph Brookes, Ariane Berdal, Juliane Isaac
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99626 (2014)
Research on enamel matrix proteins (EMPs) is centered on understanding their role in enamel biomineralization and their bioactivity for tissue engineering. While therapeutic application of EMPs has been widely documented, their expression and biologi
Externí odkaz:
https://doaj.org/article/270dbc3129d6453e9ee053f3414b16f3
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e89310 (2014)
Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration. In brain, Cdk5 activity is specific to post-mitotic neurons, due to neuronal specifi
Externí odkaz:
https://doaj.org/article/eb637fbef23a470a8267bc8c48899d01
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e74888 (2013)
The molecular mechanism of human anal squamous cell carcinoma (ASCC) is unclear, and the accumulating evidence indicate association of ASCC with the activation of the Akt/mTOR pathway. Here we describe a mouse model with spontaneous anal squamous cel
Externí odkaz:
https://doaj.org/article/deca029d370b431a9e6002e2fe98f974
Autor:
Andrew Cho, Naoto Haruyama, Bradford Hall, Mary Jo S Danton, Lu Zhang, Praveen Arany, David J Mooney, Yassine Harichane, Michel Goldberg, Carolyn W Gibson, Ashok B Kulkarni
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e82267 (2013)
Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling. Many of these processes are also an integ
Externí odkaz:
https://doaj.org/article/edabe76ea8724bed95ede251fffd2b00