Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ashna A. Khan"'
Autor:
Farah Lamiable-Oulaidi, Rajesh K. Harijan, Karl J. Shaffer, Douglas R. Crump, Yan Sun, Quan Du, Shivali A. Gulab, Ashna A. Khan, Andreas Luxenburger, Anthony D. Woolhouse, Simone Sidoli, Peter C. Tyler, Vern L. Schramm
Publikováno v:
J Med Chem
Hypermethylation of CpG regions by human DNA methyltransferase 1 (DNMT1) silences tumor-suppression genes, and inhibition of DNMT1 can reactivate silenced genes. The 5-azacytidines are approved inhibitors of DNMT1, but their mutagenic mechanism limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7e7060bedab898082ff9cd46a78e07
https://pubmed.ncbi.nlm.nih.gov/35324190
https://pubmed.ncbi.nlm.nih.gov/35324190
Autor:
Sho Yamasaki, Naoya Nishimura, Ashna A. Khan, Mattie S. M. Timmer, Bridget L. Stocker, Jessie H. Bird
Publikováno v:
The Journal of Organic Chemistry. 83:7593-7605
The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor that recognizes trehalose dimycolate (TDM), and trehalose dibehenate (TDB) and related trehalose diesters, and thus represents a promising target for the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f702b1ab3c86625d6c29cc29fdb549
https://doi.org/10.1021/acs.joc.7b03269
https://doi.org/10.1021/acs.joc.7b03269
Autor:
Stefanie Steiger, Mattie S. M. Timmer, Bridget L. Stocker, Selma Eising, Jacquie L. Harper, Kristel Kodar, Ashna A. Khan
Publikováno v:
ChemBioChem. 16:683-693
Trehalose glycolipids play an important role in the pathogenesis of Mycobacterium tuberculosis and are used as adjuvants for vaccines; however, much still remains unanswered about the mechanisms through which these glycolipids exert their immunomodul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365a04b42447fa05c113f645569bf61a
https://doi.org/10.1002/cbic.201402506
https://doi.org/10.1002/cbic.201402506
Publikováno v:
Org. Biomol. Chem.. 11:881-885
Trehalose dimycolates (TDMs) are the most abundant glycolipids found in the cell wall of Mycobacterium tuberculosis (M. tb). TDMs play an important role in the pathogenesis of M. tb yet the only known receptor for TDM is the macrophage inducible C-ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c032c40872b9ee5f609a39d87ba2ef2
https://doi.org/10.1039/c2ob27257a
https://doi.org/10.1039/c2ob27257a
Autor:
Susan M. Carnachan, Phillip M. Rendle, Steven Toms, Ching-Wen Tang, Keryn D. Johnson, Ashna A. Khan, Ian F. Hermans, Suzanne E. O'Hagan
Publikováno v:
ChemMedChem. 11(15)
Poly ethoxy ethyl glycinamide (PEE-G) dendrimers have been specifically designed and synthesized with the aim of providing a readily available dendrimer scaffold that can be used to make products that can meet the stringent requirements of pharmaceut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9d1596b789e1baa294f9fddb7a3bc8
https://pubmed.ncbi.nlm.nih.gov/27390296
https://pubmed.ncbi.nlm.nih.gov/27390296
Publikováno v:
Carbohydrate Research. 356:25-36
A variety of trehalose glycolipids have been isolated from natural sources, and several of these glycolipids exhibit important biological properties. These molecules also represent challenging synthetic targets due to their highly amphiphilic charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb17651b552978c1c52b545e1c158c3
https://doi.org/10.1016/j.carres.2012.03.010
https://doi.org/10.1016/j.carres.2012.03.010
Publikováno v:
European Journal of Organic Chemistry. 2012:995-1002
The Frater–Seebach alkylation is a highly efficient means to diastereoselectively introduce α-substituents to chiral β-hydroxy esters, however, the yields of reactions in which longer chain alkyl halides are used can be disappointing. To provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d6fa1ed024c123ecb48eb8a6e2d7194
https://doi.org/10.1002/ejoc.201101472
https://doi.org/10.1002/ejoc.201101472
Publikováno v:
International Journal of Carbohydrate Chemistry. 2011:1-13
In the same way that peptide antigens are presented by major histocompatibility complex (MHC) molecules, glycolipid antigens can also activate the immune response via binding to CD1 proteins on antigen-presenting cells (APCs) and stimulate CD1-restri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48a17bf76eaec45fed8fd703f50222e9
https://doi.org/10.1155/2011/749591
https://doi.org/10.1155/2011/749591
Publikováno v:
Chembiochem : a European journal of chemical biology. 15(3)
The C22 and C26 trehalose monoesters, each containing a single acyl chain, were synthesised in good overall yields and found to activate macrophages in a Mincle-dependent manner. The activities of the monoesters paralleled those of their diester coun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccf57a6e96cc8c0c174f77bccbaa3c8
https://pubmed.ncbi.nlm.nih.gov/24436250
https://pubmed.ncbi.nlm.nih.gov/24436250
Autor:
Ching-Wen Tang, Steven Toms, Suzanne E. O'Hagan, Ian F. Hermans, Susan M. Carnachan, Phillip M. Rendle, Ashna A. Khan, Keryn D. Johnson
Publikováno v:
ChemMedChem. 11:1668-1668
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b8f2b63b8ce42aa68d4ead495a61656
https://doi.org/10.1002/cmdc.201600377
https://doi.org/10.1002/cmdc.201600377