Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ashley Velez-Delgado"'
Autor:
Ashley Velez-Delgado, Katelyn L. Donahue, Kristee L. Brown, Wenting Du, Valerie Irizarry-Negron, Rosa E. Menjivar, Emily L. Lasse Opsahl, Nina G. Steele, Stephanie The, Jenny Lazarus, Veerin R. Sirihorachai, Wei Yan, Samantha B. Kemp, Samuel A. Kerk, Murali Bollampally, Sion Yang, Michael K. Scales, Faith R. Avritt, Fatima Lima, Costas A. Lyssiotis, Arvind Rao, Howard C. Crawford, Filip Bednar, Timothy L. Frankel, Benjamin L. Allen, Yaqing Zhang, Marina Pasca di Magliano
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1673-1699 (2022)
Background & Aims: Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse models of the disease. Although the tumor cell–intrinsic effects of onco
Externí odkaz:
https://doaj.org/article/20125fcc27cc45cf89b627da102ba12b
Autor:
Rosa E Menjivar, Zeribe C Nwosu, Wenting Du, Katelyn L Donahue, Hanna S Hong, Carlos Espinoza, Kristee Brown, Ashley Velez-Delgado, Wei Yan, Fatima Lima, Allison Bischoff, Padma Kadiyala, Daniel Salas-Escabillas, Howard C Crawford, Filip Bednar, Eileen Carpenter, Yaqing Zhang, Christopher J Halbrook, Costas A Lyssiotis, Marina Pasca di Magliano
Publikováno v:
eLife, Vol 12 (2023)
An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and contribute to the poor response to immunotherapy; however, the mechanisms
Externí odkaz:
https://doaj.org/article/2b78244f89f74a1a8452e4521a5af646
Autor:
Michael K Scales, Ashley Velez-Delgado, Nina G Steele, Hannah E Schrader, Anna M Stabnick, Wei Yan, Nayanna M Mercado Soto, Zeribe C Nwosu, Craig Johnson, Yaqing Zhang, Daniel J Salas-Escabillas, Rosa E Menjivar, H Carlo Maurer, Howard C Crawford, Filip Bednar, Kenneth P Olive, Marina Pasca di Magliano, Benjamin L Allen
Publikováno v:
PLoS Genetics, Vol 18, Iss 7, p e1010315 (2022)
Proper Hedgehog (HH) signaling is essential for embryonic development, while aberrant HH signaling drives pediatric and adult cancers. HH signaling is frequently dysregulated in pancreatic cancer, yet its role remains controversial, with both tumor-p
Externí odkaz:
https://doaj.org/article/eaf83723636e457b88ff374b523b3867
Autor:
Marina Pasca di Magliano, Filip Bednar, Timothy L. Frankel, Costas A. Lyssiotis, Howard C. Crawford, Michelle A. Anderson, Alekya Vinta, Anna C. Nevison, Valerie Irizarry-Negron, Kristee L. Brown, Eileen S. Carpenter, Katelyn Donahue, Ashley Velez-Delgado, Veerin R. Sirihorachai, Samantha B. Kemp, Rosa E. Menjivar, Christopher J. Halbrook, Zeribe C. Nwosu, Ho-Joon Lee, Wei Yan, Nina G. Steele, Jenny Lazarus, Yaqing Zhang
Supplemental figure 1 with legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bde75b91e5ddb41ec4fdc3d131335d2
https://doi.org/10.1158/2159-8290.22535420
https://doi.org/10.1158/2159-8290.22535420
Autor:
Marina Pasca di Magliano, Filip Bednar, Timothy L. Frankel, Costas A. Lyssiotis, Howard C. Crawford, Michelle A. Anderson, Alekya Vinta, Anna C. Nevison, Valerie Irizarry-Negron, Kristee L. Brown, Eileen S. Carpenter, Katelyn Donahue, Ashley Velez-Delgado, Veerin R. Sirihorachai, Samantha B. Kemp, Rosa E. Menjivar, Christopher J. Halbrook, Zeribe C. Nwosu, Ho-Joon Lee, Wei Yan, Nina G. Steele, Jenny Lazarus, Yaqing Zhang
Regulatory T cells (Treg) are abundant in human and mouse pancreatic cancer. To understand the contribution to the immunosuppressive microenvironment, we depleted Tregs in a mouse model of pancreatic cancer. Contrary to our expectations, Treg depleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2302b85563ad76a36772a8aff5c74104
https://doi.org/10.1158/2159-8290.c.6547853.v1
https://doi.org/10.1158/2159-8290.c.6547853.v1
Autor:
Howard C. Crawford, Marina Pasca di Magliano, Yaqing Zhang, Arvind Rao, Costas A. Lyssiotis, Daniel Long, Kristee Brown, Carlos E. Espinoza, Stephanie The, Fatima Lima, Rosa E. Menjivar, Ashley Velez-Delgado, Amanda Pacheco, Zeribe C. Nwosu, Katelyn L. Donahue, Nina G. Steele, Eileen S. Carpenter, Samantha B. Kemp
Figure S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1841c81c9b4b5a3d3b5b0b5776adde50
https://doi.org/10.1158/0008-5472.22353850.v1
https://doi.org/10.1158/0008-5472.22353850.v1
Autor:
Howard C. Crawford, Marina Pasca di Magliano, Yaqing Zhang, Arvind Rao, Costas A. Lyssiotis, Daniel Long, Kristee Brown, Carlos E. Espinoza, Stephanie The, Fatima Lima, Rosa E. Menjivar, Ashley Velez-Delgado, Amanda Pacheco, Zeribe C. Nwosu, Katelyn L. Donahue, Nina G. Steele, Eileen S. Carpenter, Samantha B. Kemp
Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c017118cfcea9f9a9b0e62b8b612ba
https://doi.org/10.1158/0008-5472.22353832.v1
https://doi.org/10.1158/0008-5472.22353832.v1
Autor:
Howard C. Crawford, Marina Pasca di Magliano, Yaqing Zhang, Arvind Rao, Costas A. Lyssiotis, Daniel Long, Kristee Brown, Carlos E. Espinoza, Stephanie The, Fatima Lima, Rosa E. Menjivar, Ashley Velez-Delgado, Amanda Pacheco, Zeribe C. Nwosu, Katelyn L. Donahue, Nina G. Steele, Eileen S. Carpenter, Samantha B. Kemp
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with few effective therapeutic options. PDAC is characterized by an extensive fibroinflammatory stroma that includes abundant infiltrating immune cells. Tumor-associated macrophages (TAM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2390e5b02d1eea05bfdaad045402a8e7
https://doi.org/10.1158/0008-5472.c.6490918.v1
https://doi.org/10.1158/0008-5472.c.6490918.v1
Autor:
Rosa E. Menjivar, Zeribe C. Nwosu, Wenting Du, Katelyn L. Donahue, Carlos Espinoza, Kristee Brown, Ashley Velez-Delgado, Wei Yan, Fatima Lima, Allison Bischoff, Padma Kadiyala, Daniel Salas-Escabillas, Howard Crawford, Filip Bednar, Eileen Carpenter, Yaqing Zhang, Christopher J. Halbrook, Costas A. Lyssiotis, Marina Pasca di Magliano
An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and contribute to the poor response to immunotherapy; however, the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e65b2dd55fb7040b757a8b73bd74022
https://doi.org/10.1101/2022.06.21.497084
https://doi.org/10.1101/2022.06.21.497084
Autor:
Wenting Du, Rosa E. Menjivar, Katelyn L. Donahue, Padma Kadiyala, Ashley Velez-Delgado, Kristee L. Brown, Hannah R. Watkoske, Xi He, Eileen S. Carpenter, Christina V. Angeles, Yaqing Zhang, Marina Pasca di Magliano
Publikováno v:
The Journal of experimental medicine. 220(1)
Pancreatic ductal adenocarcinoma (PDA) is associated with activation of WNT signaling. Whether this signaling pathway regulates the tumor microenvironment has remained unexplored. Through single-cell RNA sequencing of human pancreatic cancer, we disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a21166e144b9ac277ac851e0e8c8742
https://pubmed.ncbi.nlm.nih.gov/36239683
https://pubmed.ncbi.nlm.nih.gov/36239683