Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ashley V. Nywening"'
Autor:
Adela Martin-Vicente, Ana Camila Oliveira Souza, Xabier Guruceaga, Harrison I. Thorn, Jinhong Xie, Ashley V. Nywening, Wenbo Ge, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Fungal pathogens must exhibit strong nutritional plasticity, effectively sensing and utilizing diverse nutrients to support virulence. How the signals generated by nutritional sensing are efficiently translated to the morphogenetic machinery
Externí odkaz:
https://doaj.org/article/5a0472a7915f416c96e09e8fa6ce7d05
Autor:
Jinhong Xie, Jeffrey M. Rybak, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Josie E. Parker, Steven L. Kelly, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Triazoles, the most widely used class of antifungal drugs, inhibit the biosynthesis of ergosterol, a crucial component of the fungal plasma membrane. Inhibition of a separate ergosterol biosynthetic step, catalyzed by the sterol C-24 methylt
Externí odkaz:
https://doaj.org/article/5bf67aaf3a334a329c3a9686785bf735
Autor:
Jeffrey M. Rybak, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Ana C. O. Souza, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Josie E. Parker, Steven L. Kelly, Hannah M. Snell, Christina A. Cuomo, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of action of triazoles is through the specific inhibition of
Externí odkaz:
https://doaj.org/article/f05294528fb640d8a22b184dae7ef4b2
Autor:
Harrison I. Thorn, Xabier Guruceaga, Adela Martin-Vicente, Ashley V. Nywening, Jinhong Xie, Wenbo Ge, Jarrod R. Fortwendel
Publikováno v:
mSphere, Vol 9, Iss 3 (2024)
ABSTRACTAspergillus fumigatus is a major invasive mold pathogen and the most frequent etiologic agent of invasive aspergillosis. The currently available treatments for invasive aspergillosis are limited in both number and efficacy. Our recent work ha
Externí odkaz:
https://doaj.org/article/7ddc1d00b17f49cdb51d639cab468426
Autor:
Xabier Guruceaga, Uxue Perez-Cuesta, Adela Martin-Vicente, Eduardo Pelegri-Martinez, Harrison I. Thorn, Saioa Cendon-Sanchez, Jinhong Xie, Ashley V. Nywening, Andoni Ramirez-Garcia, Jarrod R. Fortwendel, Aitor Rementeria
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
In this study, two distinct in vitro infection models of Aspergillus fumigatus, using murine macrophages (RAW264.7) and human lung epithelial cells (A549), were employed to identify the genes important for fungal adaptation during infection. Transcri
Externí odkaz:
https://doaj.org/article/ed608cd0adf649ad8318efe5f7449234
Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Autor:
Ana Camila Oliveira Souza, Qusai Al Abdallah, Kaci DeJarnette, Adela Martin-Vicente, Ashley V. Nywening, Christian DeJarnette, Emily A. Sansevere, Wenbo Ge, Glen E. Palmer, Jarrod R Fortwendel
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 511-526 (2019)
Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique β-subunit
Externí odkaz:
https://doaj.org/article/a848674584e84a41bcf24b18b8f96f11
Autor:
Evan P. Williams, Briana M. Spruill-Harrell, Mariah K. Taylor, Jasper Lee, Ashley V. Nywening, Zemin Yang, Jacob H. Nichols, Jeremy V. Camp, Robert D. Owen, Colleen B. Jonsson
Publikováno v:
Viruses, Vol 13, Iss 8, p 1509 (2021)
Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest percentage of living mammals on earth. Thus, it is not surprising that these two orders account for many of the reservoirs of the zoonotic RNA viruses discovered to d
Externí odkaz:
https://doaj.org/article/b2686130323b4b6fb375fe1c7e15fa4e
Publikováno v:
Journal of Fungi, Vol 6, Iss 4, p 285 (2020)
Cell polarization comprises highly controlled processes and occurs in most eukaryotic organisms. In yeast, the processes of budding, mating and filamentation require coordinated mechanisms leading to polarized growth. Filamentous fungi, such as Asper
Externí odkaz:
https://doaj.org/article/7fe0f56331aa4bbeb0b86e8196a9fd6b
Publikováno v:
Environ Microbiol
The ubiquitous fungal pathogen Aspergillus fumigatus is the primary cause of opportunistic mould infections in humans. Aspergilli disseminate via asexual conidia passively travelling through air currents to germinate within a broad range of environs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d1e3fff1631b2969c7f73cae4209b6
https://doi.org/10.1111/1462-2920.15274
https://doi.org/10.1111/1462-2920.15274
Autor:
Colleen B. Jonsson, Briana Spruill-Harrell, Jacob H Nichols, Mariah K. Taylor, Zemin Yang, Evan P. Williams, Jeremy V. Camp, Robert D. Owen, Ashley V. Nywening, Jasper Lee
Publikováno v:
Viruses
Viruses, Vol 13, Iss 1509, p 1509 (2021)
Viruses, Vol 13, Iss 1509, p 1509 (2021)
Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest percentage of living mammals on earth. Thus, it is not surprising that these two orders account for many of the reservoirs of the zoonotic RNA viruses discovered to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2b817b6a3f5bdd3c26fda5b78f1c4d
https://pubmed.ncbi.nlm.nih.gov/34452374
https://pubmed.ncbi.nlm.nih.gov/34452374