Zobrazeno 1 - 10 of 74 pro vyhledávání: '"Ashley V Menk"'
1
Akademický článek
Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors
Autor: Benjamin Boyerinas, Greg M Delgoffe, Yupeng Wang, Alok Kumar, Ashley V Menk, Konstantinos Lontos, Yiyang Wang, Jason Lohmueller, Supriya K Joshi, Andrew T Frisch, McLane J Watson, Rachel Cumberland, Esteban Carrizosa
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Cellular immunotherapies for cancer represent a means by which a patient’s immune system can be augmented with high numbers of tumor-specific T cells. Chimeric antigen receptor (CAR) therapy involves genetic engineering to ‘redirect’
Externí odkaz: https://doaj.org/article/fd472df9a6d743fab850b3a2c42e8947
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2
Akademický článek
Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck
Autor: Greg M Delgoffe, Kristin DePeaux, Angen Liu, Dan P Zandberg, Ashley V Menk, Maria Velez, Daniel Normolle
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
The majority of patients with recurrent/metastatic squamous cell carcinoma of the head and neck (HNSCC) (R/M) do not benefit from anti-PD-1 therapy. Hypoxia induced immunosuppression may be a barrier to immunotherapy. Therefore, we examined the metab
Externí odkaz: https://doaj.org/article/d0916971c66149a6a4ea79c16d0bb5d0
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4
Akademický článek
Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions
Autor: Ashley V. Menk, Nicole E. Scharping, Rebecca S. Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A. Young, Stacy Gelhaus Wendell, Greg M. Delgoffe
Publikováno v: Cell Reports, Vol 22, Iss 6, Pp 1509-1521 (2018)
Summary: To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events
Externí odkaz: https://doaj.org/article/9a323dcf2c784882a7635f4587454ea7
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5
Akademický článek
mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells
Autor: Alicia R. Watson, Helong Dai, Yawen Zheng, Ryosuke Nakano, Anastasios D. Giannou, Ashley V. Menk, Donna B. Stolz, Greg M. Delgoffe, Angus W. Thomson
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
In myeloid dendritic cells (DC), deletion of the mechanistic target of rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, the underlying mechanism has not been resolved. Here, we d
Externí odkaz: https://doaj.org/article/8d8baed11249439eb87f816f70d2d5fe
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6
Akademický článek
Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells
Autor: Dana M. Previte, Christina P. Martins, Erin C. O’Connor, Meghan L. Marre, Gina M. Coudriet, Noah W. Beck, Ashley V. Menk, Rebecca H. Wright, Hubert M. Tse, Greg M. Delgoffe, Jon D. Piganelli
Publikováno v: Cell Reports, Vol 27, Iss 1, Pp 129-141.e4 (2019)
Summary: Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor expressed by CD4+ T cells and tempers their homeostatic expansion. Because CD4+ T cell proliferation is tightly coupled to bioenergetics, we investigate the role of LAG-3 in modu
Externí odkaz: https://doaj.org/article/5973900a5fa04fefa8bb32117570e50d
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