Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ashley Summers"'
Autor:
James W. Gilbert, Zachary Kennedy, Bruno M.D.C. Godinho, Ashley Summers, Alexandra Weiss, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, David Cooper, Ken Yamada, Matthew Hassler, Hélène Tran, Fen Biao Gao, Robert H. Brown, Jr., Anastasia Khvorova
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102291- (2024)
A hexanucleotide (G4C2) repeat expansion (HRE) within intron one of C9ORF72 is the leading genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). C9ORF72 haploinsufficiency, formation of RNA foci, and production of di
Externí odkaz:
https://doaj.org/article/48f420ec0d5f4364889fb47b75a6618c
Autor:
Qi Tang, Hassan H. Fakih, Mohammad Zain UI Abideen, Samuel R. Hildebrand, Khashayar Afshari, Katherine Y. Gross, Jacquelyn Sousa, Allison S. Maebius, Christina Bartholdy, Pia Pernille Søgaard, Malene Jackerott, Vignesh Hariharan, Ashley Summers, Xueli Fan, Ken Okamura, Kathryn R. Monopoli, David A. Cooper, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, Raymond C. Furgal, Karen Dresser, Sarah J. Winter, Annabelle Biscans, Jane Chuprin, Nazgol-Sadat Haddadi, Shany Sherman, Ümmügülsüm Yıldız-Altay, Mehdi Rashighi, Jillian M. Richmond, Claire Bouix-Peter, Carine Blanchard, Adam Clauss, Julia F. Alterman, Anastasia Khvorova, John E. Harris
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors show distinct efficacy and safety profiles, likely reflecting variable
Externí odkaz:
https://doaj.org/article/4a8cb6635b9d4fb98e9074b6bcb3b50f
Autor:
Hassan H. Fakih, Qi Tang, Ashley Summers, Minwook Shin, Julianna E. Buchwald, Rosemary Gagnon, Vignesh N. Hariharan, Dimas Echeverria, David A. Cooper, Jonathan K. Watts, Anastasia Khvorova, Hanadi F. Sleiman
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102080- (2023)
Although an increasing number of small interfering RNA (siRNA) therapies are reaching the market, the challenge of efficient extra-hepatic delivery continues to limit their full therapeutic potential. Drug delivery vehicles and hydrophobic conjugates
Externí odkaz:
https://doaj.org/article/b2737ae9f41849d78fd6f4851c674ed3
Publikováno v:
IET Radar, Sonar & Navigation, Vol 15, Iss 1, Pp 85-100 (2021)
Abstract We address the problem of co‐channel interference (CCI) in multi‐channel airborne passive radars using digital broadcast signals of opportunity. A framework for suppressing the CCI is proposed, based on a two‐stage approach, which refl
Externí odkaz:
https://doaj.org/article/9d77e8639bfa4969a1960430feebf39f
Autor:
Brendan Hennessy, Mark Rutten, Robert Young, Steven Tingay, Ashley Summers, Daniel Gustainis, Brian Crosse, Marcin Sokolowski
Publikováno v:
Remote Sensing, Vol 14, Iss 11, p 2571 (2022)
This paper describes the use of the Murchison Widefield Array, a low-frequency radio telescope at a radio-quiet Western Australian site, as a radar receiver forming part of a continent-spanning multistatic radar network for the surveillance of space.
Externí odkaz:
https://doaj.org/article/142783fd0fbe4aecbbb9ef4939cabe7c
Autor:
Daniel O'Reilly, Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh, Ella Mathews, Adel Boudi, Julianna Buchwald, Socheata Ly, Dimas Moreno, Raymond Furgal, Eric Luu, Zachary Kennedy, Vignesh Hariharan, Kathryn Monopoli, X. William Yang, Jeffery Carroll, Marian DiFiglia, Neil Aronin, Anastasia Khvorova
Publikováno v:
Molecular Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d44db32c4893997bcd51e5eccde0fb
https://doi.org/10.1016/j.ymthe.2023.05.006
https://doi.org/10.1016/j.ymthe.2023.05.006
Autor:
Daniel O’Reilly, Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh, Ella Mathews, Julianna Buchwald, Socheata Ly, Dimas Echeverria Moreno, Zachary Kennedy, Vignesh Hariharan, Kathryn Monopoli, X. William Yang, Jeffery Carroll, Marian DiFiglia, Neil Aronin, Anastasia Khvorova
Huntington’s Disease (HD) is a severe neurodegenerative disorder caused by expansion of the CAG trinucleotide repeat tract in the huntingtin gene. Inheritance of expanded CAG repeats is needed for HD manifestation, but further somatic expansion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85abae4738303ac45e081a5dee520ab
https://doi.org/10.1101/2022.09.06.506795
https://doi.org/10.1101/2022.09.06.506795
Autor:
Ashley Summers, Xiaoyu Xue, Stephen So, Bingbing Wan, Shibai Li, Xiaolan Zhao, Leticia Gonzalez, Jacob N. Bonner
Publikováno v:
Genes Dev
SUMO modification regulates diverse cellular processes by targeting hundreds of proteins. However, the limited number of sumoylation enzymes raises the question of how such a large number of substrates are efficiently modified. Specifically, how geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a87fb6f2d7ce997394eca3ca0715fd8
https://doi.org/10.1101/gad.344739.120
https://doi.org/10.1101/gad.344739.120
Publikováno v:
2020 IEEE Radar Conference (RadarConf20).
Passive radar utilizes signals from broadcast, communication, or other transmitters of opportunity for the applications of target detection and imaging. For these applications knowledge of the transmitted signal for the correlation with the surveilla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f95be09f6cd4df8cd7f5551cf5e611c3
https://doi.org/10.1109/radarconf2043947.2020.9266682
https://doi.org/10.1109/radarconf2043947.2020.9266682
Publikováno v:
IEEE Transactions on Aerospace and Electronic Systems. 54:1341-1354
We investigate effects of transmitter imperfections in terms of time and frequency offsets on the performance of digital video broadcast-terrestrial based passive radars. To facilitate an accurate reconstruction of the transmitted waveform, transmitt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e192448d6de154e2cf75e6466f7b84
https://doi.org/10.1109/taes.2017.2785518
https://doi.org/10.1109/taes.2017.2785518