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pro vyhledávání: '"Ashley Smuder"'
Publikováno v:
Physiology. 38
Background: Cancer patients treated with FOLFOX are burdened by an array of side effects which can lead to early cessation of treatment. Specifically, FOLFOX is associated with increases in arterial stiffness, LV-stunning/weakness, both of which can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bacd1dab5e47e7e809c3a09eb2e936a
https://doi.org/10.1152/physiol.2023.38.s1.5732952
https://doi.org/10.1152/physiol.2023.38.s1.5732952
Publikováno v:
Physiology. 38
Doxorubicin (DOX) is a first-line chemotherapeutic agent used to treat a wide range of malignancies including breast and lymphatic cancers. However, the clinical use of DOX is limited due to off-target toxicity to healthy organs. DOX-induced nephroto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b4ca06a82341a07b9c400bdba7a2c2b
https://doi.org/10.1152/physiol.2023.38.s1.5732553
https://doi.org/10.1152/physiol.2023.38.s1.5732553
Publikováno v:
Physiology. 38
Doxorubicin (DOX)-induced cardiotoxicity results in an increased risk of mortality among chemotherapy recipients. Cardiomyocyte dysfunction is caused by the off-target accumulation of DOX in cardiac mitochondria, stimulating oxidative damage and impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95fd38d04b8665e7b0e5f3976975eead
https://doi.org/10.1152/physiol.2023.38.s1.5732530
https://doi.org/10.1152/physiol.2023.38.s1.5732530
Autor:
Vivian Doerr, Ryan Montalvo, Cesar Jacintho Moritz, Franccesco Boeno, Imtiaz Dowllah, Ashley Smuder
Publikováno v:
Physiology. 38
Doxorubicin (DOX) is a highly effective chemotherapeutic used in cancer treatment. However, its use is associated with the development of cardiac dysfunction, which can negatively affect patient outcomes and reduce overall survival. While no clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71df36e8d3d7dfa00b22143a95095f9a
https://doi.org/10.1152/physiol.2023.38.s1.5796072
https://doi.org/10.1152/physiol.2023.38.s1.5796072
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79bfd38515e19b3250a6efed870b14f3
https://doi.org/10.1096/fasebj.2022.36.s1.r3404
https://doi.org/10.1096/fasebj.2022.36.s1.r3404