Výsledky vyhledávání - "Ashley S Williams"

Akademický článek

SIRT2 knockout exacerbates insulin resistance in high fat-fed mice.

Autor: Louise Lantier, Ashley S Williams, Curtis C Hughey, Deanna P Bracy, Freyja D James, Muhammad A Ansari, David Gius, David H Wasserman

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0208634 (2018)

The NAD+-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the cytosol, as well as the mitochondria. Defining the role of cytosolic acetylation state in specific tissues is difficult since even physiological effects at the

Externí odkaz: https://doaj.org/article/6ef0b042180f4c73a161d221e72acb4c

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Akademický článek

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics

Autor: Kelsey H. Fisher-Wellman, James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, Robert D. Stevens, Gregory R. Wagner, Rami Najjar, Mathew D. Hirschey, J. Will Thompson, David P. Olson, Daniel P. Kelly, Timothy R. Koves, Paul A. Grimsrud, Deborah M. Muoio

Publikováno v: Cell Reports, Vol 26, Iss 6, Pp 1557-1572.e8 (2019)

Summary: Acyl CoA metabolites derived from the catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translational modifications (PTMs). Mass spectrometry-based detection of thousan

Externí odkaz: https://doaj.org/article/39224f9c894241779cbc18a277e18c11

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Machine learning interatomic potential for simulations of carbon at extreme conditions

Autor: Jonathan T. Willman, Kien Nguyen-Cong, Ashley S. Williams, Anatoly B. Belonoshko, Stan G. Moore, Aidan P. Thompson, Mitchell A. Wood, Ivan I. Oleynik

Publikováno v: Physical Review B. 106

A Spectral Neighbor Analysis (SNAP) machine learning interatomic potential (MLIP) has been developed for simulations of carbon at extreme pressures (up to 5 TPa) and temperatures (up to 20,000 K). This was achieved using a large database of experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51acfff55e3987eb4e17d95882ad2f71
https://doi.org/10.1103/physrevb.106.l180101

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The persistent effects of corticosterone administration during lactation on the physiology of maternal and offspring mitochondria

Autor: Kang Nian Yap, Victoria A. Andreasen, Ashley S. Williams, KayLene Y. Yamada, Shelby Zikeli, Andreas N. Kavazis, Wendy R. Hood

Publikováno v: Journal of Experimental Biology

Reproduction and environmental stressors are generally thought to be associated with a cost to the individual experiencing them, but the physiological mechanisms mediating costs of reproduction and maternal effects remain poorly understood. Studies e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b748e533bea87939844cb00bb3d8ee4b
https://doi.org/10.1242/jeb.244171

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Mitochondrial physiology varies with parity and body mass in the laboratory mouse (Mus musculus)

Autor: Noel R. Park, Ashley S Williams, Halie A. Taylor, Andreas N. Kavazis, Kang Nian Yap, Victoria A. Andreasen, Kristjan Niitepõld, Wendy R. Hood

Publikováno v: Journal of Comparative Physiology B. 190:465-477

The life-history patterns that animals display are a product of their ability to maximize reproductive performance while concurrently balancing numerous metabolic demands. For example, the energetic costs of reproduction may reduce an animal's abilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a4760a86e9f00a72a8a07bd32f3abbf
https://doi.org/10.1007/s00360-020-01285-2

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Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon

Autor: Ashley S. Williams, Monika L. Bayer, Michael Kjaer, David H. Wasserman, Rene B. Svensson, Peter Schjerling

Publikováno v: Cell and Tissue Research. 381:177-187

Integrins are important for mechanosensation in tissue and play, together with nutrition, a role in regulating extracellular matrix (ECM) in skeletal muscle and tendon. Integrin receptors are dimers that consist of an α and β subunit and bridge ext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a80047e1de26fe1d3e6761e816b995f
https://doi.org/10.1007/s00441-020-03184-y

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Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome

Autor: Ashley S. Williams, Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, Deborah M. Muoio

Publikováno v: iScience
iScience, Vol 25, Iss 1, Pp 103635-(2022)

Summary Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD+) biosynthesis, mitochondrial function, and/or the activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee5a842a1bfebf16185dec3fa62731b
http://europepmc.org/articles/PMC8741497

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Examination of mercury contamination from a recent coal ash spill into the Dan River, North Carolina, United States

Autor: Martin Tsz-Ki Tsui, Songnian Liu, Peijia Ku, Ashley S. Williams, Parke A. Rublee, Anne E. Hershey, Matthew R. Monteverde, Glenn E. Woerndle, Kimber B. Corson

Publikováno v: Ecotoxicology and Environmental Safety, Vol 208, Iss, Pp 111469-(2021)

Coal ash spills occasionally occur due to the accidental failure of surface impoundments, and toxic metal-laden ash can pose a serious health threat to adjacent aquatic ecosystems. Here, we performed an investigation into longitudinal variations of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a938aba4a8546b83b8a1659902d2ae33
http://www.sciencedirect.com/science/article/pii/S0147651320313063

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