Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ashley S, Margol"'
Autor:
Zhehao Hu, Anthony G. Christodoulou, Nan Wang, Yibin Xie, Mark S. Shiroishi, Wensha Yang, Gabriel Zada, Frances E. Chow, Ashley S. Margol, Benita Tamrazi, Eric L. Chang, Debiao Li, Zhaoyang Fan
Publikováno v:
Magnetic Resonance in Medicine. 89:161-176
Autor:
Kee Kiat Yeo, Sanda Alexandrescu, Jennifer A Cotter, Jayne Vogelzang, Varun Bhave, Marilyn M Li, Jianling Ji, Jamal K Benhamida, Marc K Rosenblum, Tejus A Bale, Nancy Bouvier, Kristiyana Kaneva, Tom Rosenberg, Mary Jane Lim-Fat, Hia Ghosh, Migdalia Martinez, Dolly Aguilera, Amy Smith, Stewart Goldman, Eli L Diamond, Igor Gavrilovic, Tobey J MacDonald, Matthew D Wood, Kellie J Nazemi, AiLien Truong, Andrew Cluster, Keith L Ligon, Kristina Cole, Wenya Linda Bi, Ashley S Margol, Matthias A Karajannis, Karen D Wright
Publikováno v:
Neuro Oncol
Background The incidence and biology of IDH1/2 mutations in pediatric gliomas are unclear. Notably, current treatment approaches by pediatric and adult providers vary significantly. We describe the frequency and clinical outcomes of IDH1/2-mutant gli
Autor:
Tom Rosenberg, Kee Kiat Yeo, Audrey Mauguen, Sanda Alexandrescu, Sanjay P Prabhu, Jessica W Tsai, Seth Malinowski, Mrinal Joshirao, Karishma Parikh, Sameer Farouk Sait, Marc K Rosenblum, Jamal K Benhamida, George Michaiel, Hung N Tran, Sonika Dahiya, Kara Kachurak, Gregory K Friedman, Julie I Krystal, Michael A Huang, Ashley S Margol, Karen D Wright, Dolly Aguilera, Tobey J MacDonald, Susan N Chi, Matthias A Karajannis
Publikováno v:
Neuro Oncol
Background The prognosis for patients with pediatric high-grade glioma (pHGG) is poor despite aggressive multimodal therapy. Objective responses to targeted therapy with BRAF inhibitors have been reported in some patients with recurrent BRAF-mutant p
Autor:
Shahab Asgharzadeh, Richard Sposto, Alexander R. Judkins, Floyd H. Gilles, Maryam Fouladi, Rachid Drissi, Mark D. Krieger, Anat Erdreich-Epstein, Jonathan L. Finlay, Girish Dhall, Marzieh Vali, Rebekah J. Kennedy, Long T. Hung, Janahan Gnanachandran, Nathan J. Robison, Ashley S. Margol
Purpose: Medulloblastoma in children can be categorized into at least four molecular subgroups, offering the potential for targeted therapeutic approaches to reduce treatment-related morbidities. Little is known about the role of tumor microenvironme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd31f55c5e74e01bfea6921a6e0eb52e
https://doi.org/10.1158/1078-0432.c.6523955.v1
https://doi.org/10.1158/1078-0432.c.6523955.v1
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file 92K, Supplemental Fig 5: Expression of PID1 protein in human brain tumors and cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82bea2b8c767c454086e43a6cb428cd
https://doi.org/10.1158/1078-0432.22449965
https://doi.org/10.1158/1078-0432.22449965
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 190K, Supplemental Fig 2: Proneural and Neural GBMs have higher PID1 mRNA; higher PID1 mRNA correlates with higher OS in patients with gliomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc273645c3c2cb62aa3119bfff91078
https://doi.org/10.1158/1078-0432.22449974.v1
https://doi.org/10.1158/1078-0432.22449974.v1
Autor:
Shahab Asgharzadeh, Richard Sposto, Alexander R. Judkins, Floyd H. Gilles, Maryam Fouladi, Rachid Drissi, Mark D. Krieger, Anat Erdreich-Epstein, Jonathan L. Finlay, Girish Dhall, Marzieh Vali, Rebekah J. Kennedy, Long T. Hung, Janahan Gnanachandran, Nathan J. Robison, Ashley S. Margol
Supplemental Methods and Supplemental Figures 1-9 Supplemental Figure 1. Overview of samples studies and 31-gene signature development Supplemental Figure. 2. Non-negative matrix factorization (NMF) analysis of the combined cohort of medulloblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc400b3af0732be204c09018d938fe0
https://doi.org/10.1158/1078-0432.22458464
https://doi.org/10.1158/1078-0432.22458464
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 159K, Supplemental Fig 1: PID1 mRNA is lower in less favorable medulloblastomas in two additional independent datasets; PID1 mRNA correlates with rf-PFS when analyzing CHLA medulloblastomas by tertiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc3d85666d5ca39bff7ed5663e6d04d
https://doi.org/10.1158/1078-0432.22449977.v1
https://doi.org/10.1158/1078-0432.22449977.v1
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 17K, Supplemental Fig 4: PID1 increases the proportion of cells in Sub G0/G1 in CHLA-259 medulloblastoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61093f972bcf75092590c405fa1c3215
https://doi.org/10.1158/1078-0432.22449968
https://doi.org/10.1158/1078-0432.22449968
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
Purpose: We present here the first report of PID1 (Phosphotyrosine Interaction Domain containing 1; NYGGF4) in cancer. PID1 was identified in 2006 as a gene that modulates insulin signaling and mitochondrial function in adipocytes and muscle cells.Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c143c3c543fc8e4407e7c83c12e25822
https://doi.org/10.1158/1078-0432.c.6521810
https://doi.org/10.1158/1078-0432.c.6521810