Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ashley Regazzi"'
Autor:
Jeppe Sejerø Holm, Samuel A. Funt, Annie Borch, Kamilla Kjærgaard Munk, Anne-Mette Bjerregaard, James L. Reading, Colleen Maher, Ashley Regazzi, Phillip Wong, Hikmat Al-Ahmadie, Gopa Iyer, Tripti Tamhane, Amalie Kai Bentzen, Nana Overgaard Herschend, Susan De Wolf, Alexandra Snyder, Taha Merghoub, Jedd D. Wolchok, Morten Nielsen, Jonathan E. Rosenberg, Dean F. Bajorin, Sine Reker Hadrup
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Immune checkpoint blockade therapy is successful in a high proportion of cancer patients, but others remain unresponsive. Authors here show that therapeutic success might be predictable in metastatic bladder cancer by longitudinal analysis of the ear
Externí odkaz:
https://doaj.org/article/1e76437c13374a28980b345248e7b551
Autor:
Samuel A. Funt, Michael Lattanzi, Karissa Whiting, Hikmat Al-Ahmadie, Colleen Quinlan, Min Yuen Teo, Chung-Han Lee, David Aggen, Danielle Zimmerman, Deaglan McHugh, Arlyn Apollo, Trey D. Durdin, Hong Truong, Jeffrey Kamradt, Maged Khalil, Bradley Lash, Irina Ostrovnaya, Asia S. McCoy, Grace Hettich, Ashley Regazzi, Marwah Jihad, Neha Ratna, Abigail Boswell, Kaitlyn Francese, Yuanquan Yang, Edmund Folefac, Harry W. Herr, S. Machele Donat, Eugene Pietzak, Eugene K. Cha, Timothy F. Donahue, Alvin C. Goh, William C. Huang, Dean F. Bajorin, Gopa Iyer, Bernard H. Bochner, Arjun V. Balar, Amir Mortazavi, Jonathan E. Rosenberg
Publikováno v:
J Clin Oncol
PURPOSE Neoadjuvant gemcitabine and cisplatin (GC) followed by radical cystectomy (RC) is standard for patients with muscle-invasive bladder cancer (MIBC). On the basis of the activity of atezolizumab (A) in metastatic BC, we tested neoadjuvant GC pl
Autor:
Ali Mouzannar, Karissa Whiting, Irina Ostrovnaya, Andrew Katims, Trey Durdin, Zachary Feuer, Michael Lattanzi, Hikmat Al-Ahmadie, Colleen Quinlan, Min Teo, David Aggen, Hong Truong, Jeffrey Kamradt, Maged Khalil, Bradley Lash, Ashley Regazzi, Marwah Jihad, Neha Ratna, Abigail Boswell, Yuanquan Yang, Kamal Pohar, Harry Herr, Sherri Donat, Eugene Pietzak, Eugene Cha, Timothy Donahue, William Huang, Dean Bajorin, Gopakumar Iyer, Bernard Bochner, Amir Mortazavi, Arjun Balar, Jonathan Rosenberg, Samuel Funt, Alvin Goh
Publikováno v:
Journal of Urology. 209
Autor:
Michal Sarfaty, Mahdi Golkaram, Samuel A. Funt, Hikmat Al-Ahmadie, Shannon Kaplan, Fan Song, Ashley Regazzi, Vladimir Makarov, Fengshen Kuo, Irina Ostrovnaya, Venkatraman Seshan, Chen Zhao, Benjamin Greenbaum, Li Liu, Jonathan E. Rosenberg, Timothy A. Chan
Publikováno v:
Journal of Clinical Oncology.
PURPOSE Immune checkpoint blockade (ICB) therapy has significantly improved clinical outcomes in bladder cancer. Identification of correlates of benefit is critical to select appropriate therapy for individual patients. METHODS To reveal genetic vari
Autor:
Jeppe Sejerø Holm, Samuel A. Funt, Annie Borch, Kamilla Kjærgaard Munk, Anne-Mette Bjerregaard, James L. Reading, Colleen Maher, Ashley Regazzi, Phillip Wong, Hikmat Al-Ahmadie, Gopa Iyer, Tripti Tamhane, Amalie Kai Bentzen, Nana Overgaard Herschend, Susan De Wolf, Alexandra Snyder, Taha Merghoub, Jedd D. Wolchok, Morten Nielsen, Jonathan E. Rosenberg, Dean F. Bajorin, Sine Reker Hadrup
Publikováno v:
Holm, J S, Funt, S A, Borch, A, Munk, K K, Bjerregaard, A-M, Reading, J L, Maher, C, Regazzi, A, Wong, P, Al-Ahmadie, H, Iyer, G, Tamhane, T, Bentzen, A K, Herschend, N O, De Wolf, S, Snyder, A, Merghoub, T, Wolchok, J D, Nielsen, M, Rosenberg, J E, Bajorin, D F & Hadrup, S R 2022, ' Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma ', Nature Communications, vol. 13, 1935 . https://doi.org/10.1038/s41467-022-29342-0
CD8+ T cell reactivity towards tumor mutation-derived neoantigens is widely believed to facilitate the antitumor immunity induced by immune checkpoint blockade (ICB). Here we show that broadening in the number of neoantigen-reactive CD8+ T cell (NART