Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ashley R. Maiuri"'
Publikováno v:
Epigenetics, Vol 14, Iss 12, Pp 1209-1223 (2019)
Chronic inflammation is strongly associated with an increased risk of developing colorectal cancer. DNA hypermethylation of CpG islands alters the expression of genes in cancer cells and plays an important role in carcinogenesis. Chronic inflammation
Externí odkaz:
https://doaj.org/article/2bf073048d954c348f2a2b9a572917e0
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-11 (2018)
Abstract Background Inflammation, metabolism, and epigenetic modulation are highly interconnected processes that can be altered during tumorigenesis. However, because of the complexity of these interactions, direct cause and effect during tumorigenes
Externí odkaz:
https://doaj.org/article/3e2fffe2c9cf47de91cd35fa96c04cd8
Autor:
Cynthia L. Sears, Franck Housseau, Heather M. O'Hagan, Stephen B. Baylin, Robert A. Anders, Sepideh Besharati, Angelo M. De Marzo, Hao Wang, Douglas B. Rusch, Ram Podicheti, Shruthi Sriramkumar, Ashley R. Maiuri, John Michel, Hongni Fan, Christine M. Dejea, June L. Chan, Ada J. Tam, Jessica L. Hicks, Alyssa Wenzel, Liam Chung, James R. White, Christina E. DeStefano Shields
Differential methylation values for methylation-binding domain sequencing (MBDseq) for sham and ETBF-colonized normal epithelium and tumors from Min and BRAFV600ELgr5CreMin (BLM) colons.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976abf85227f45ce0ca13bee5c61cfa9
https://doi.org/10.1158/2159-8290.22540270.v1
https://doi.org/10.1158/2159-8290.22540270.v1
Autor:
Cynthia L. Sears, Franck Housseau, Heather M. O'Hagan, Stephen B. Baylin, Robert A. Anders, Sepideh Besharati, Angelo M. De Marzo, Hao Wang, Douglas B. Rusch, Ram Podicheti, Shruthi Sriramkumar, Ashley R. Maiuri, John Michel, Hongni Fan, Christine M. Dejea, June L. Chan, Ada J. Tam, Jessica L. Hicks, Alyssa Wenzel, Liam Chung, James R. White, Christina E. DeStefano Shields
Supplementary Figures 1-6; Table S4: Tumors from ETBF-colonized BRAFV600ELgr5CreMin (BLM) mice are MSI negative; Table S6: Primer sequences for qMSP and assays used for Taqman gene expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836113c42e53c55422cc9c54f512311b
https://doi.org/10.1158/2159-8290.22540276
https://doi.org/10.1158/2159-8290.22540276
Autor:
Cynthia L. Sears, Franck Housseau, Heather M. O'Hagan, Stephen B. Baylin, Robert A. Anders, Sepideh Besharati, Angelo M. De Marzo, Hao Wang, Douglas B. Rusch, Ram Podicheti, Shruthi Sriramkumar, Ashley R. Maiuri, John Michel, Hongni Fan, Christine M. Dejea, June L. Chan, Ada J. Tam, Jessica L. Hicks, Alyssa Wenzel, Liam Chung, James R. White, Christina E. DeStefano Shields
Colorectal cancer is multifaceted, with subtypes defined by genetic, histologic, and immunologic features that are potentially influenced by inflammation, mutagens, and/or microbiota. Colorectal cancers with activating mutations in BRAF are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a526c0fa8ded8e7a89042195bc05ed
https://doi.org/10.1158/2159-8290.c.6549334
https://doi.org/10.1158/2159-8290.c.6549334
Autor:
Heather M. O'Hagan, Cynthia L. Sears, Christina E. DeStefano Shields, Douglas B. Rusch, Caitlin M. Kamplain, Shruthi Sriramkumar, Ram Podicheti, Michael Peng, Ashley R. Maiuri
Figure S1 provides additional analysis of DMRs, including genic location, bivalent status, methylation validation, and IPA analysis. Figure S2 provides evidence supporting the finding that oxidative damage-induced gene expression changes occur in epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f639ddeb9247afa2b057ac9b46eecb
https://doi.org/10.1158/0008-5472.22414269
https://doi.org/10.1158/0008-5472.22414269
Autor:
Heather M. O'Hagan, Cynthia L. Sears, Christina E. DeStefano Shields, Douglas B. Rusch, Caitlin M. Kamplain, Shruthi Sriramkumar, Ram Podicheti, Michael Peng, Ashley R. Maiuri
OTUs with significant differential abundance between the various groups and OTUs used in the heatmap in Figure 4B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bda90fc5f4799970d1a3ef445b545f0
https://doi.org/10.1158/0008-5472.22414257
https://doi.org/10.1158/0008-5472.22414257
Autor:
Heather M. O'Hagan, Cynthia L. Sears, Christina E. DeStefano Shields, Douglas B. Rusch, Caitlin M. Kamplain, Shruthi Sriramkumar, Ram Podicheti, Michael Peng, Ashley R. Maiuri
Supplemental Methods for the MBD-seq analysis and Table S1, which provides primer sequences and assays used for Taqman and pyrosequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aaeada51600f109c405bce7150ae677
https://doi.org/10.1158/0008-5472.22414266
https://doi.org/10.1158/0008-5472.22414266
Autor:
Heather M. O'Hagan, Cynthia L. Sears, Christina E. DeStefano Shields, Douglas B. Rusch, Caitlin M. Kamplain, Shruthi Sriramkumar, Ram Podicheti, Michael Peng, Ashley R. Maiuri
Aberrant silencing of genes by DNA methylation contributes to cancer, yet how this process is initiated remains unclear. Using a murine model of inflammation-induced tumorigenesis, we tested the hypothesis that inflammation promotes recruitment of ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f742a452dddad9d08495d1db6cce6ce
https://doi.org/10.1158/0008-5472.c.6508926.v1
https://doi.org/10.1158/0008-5472.c.6508926.v1
Autor:
June L. Chan, Christine M. Dejea, Shruthi Sriramkumar, Sepideh Besharati, John H. Michel, Hongni Fan, Hao Wang, Alyssa Wenzel, Franck Housseau, Robert A. Anders, Liam Chung, Jessica L. Hicks, Angelo M. De Marzo, Ram Podicheti, Ada J. Tam, Ashley R. Maiuri, James R. White, Stephen B. Baylin, Christina E. DeStefano Shields, Douglas B. Rusch, Heather M. O'Hagan, Cynthia L. Sears
Publikováno v:
Cancer Discovery. 11:1792-1807
Colorectal cancer is multifaceted, with subtypes defined by genetic, histologic, and immunologic features that are potentially influenced by inflammation, mutagens, and/or microbiota. Colorectal cancers with activating mutations in BRAF are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba4ebd42704c5dccd75fdba58e3f3cb
https://doi.org/10.1158/2159-8290.cd-20-0770
https://doi.org/10.1158/2159-8290.cd-20-0770