Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Autor: Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer

Publikováno v: eLife, Vol 9 (2020)

Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol

Externí odkaz: https://doaj.org/article/0801b66fbced40e4a16cb9a6776b1379

Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma

Autor: Ryan M. Samuel, Albertas Navickas, Ashley Maynard, Eliza A. Gaylord, Kristle Garcia, Samyukta Bhat, Homa Majd, Mikayla N. Richter, Nicholas Elder, Daniel Le, Phi Nguyen, Bradley Shibata, Marta Losa Llabata, Licia Selleri, Diana J. Laird, Spyros Darmanis, Hani Goodarzi, Faranak Fattahi

Publikováno v: bioRxiv

Summary/AbstractThe neural crest (NC) is highly multipotent and generates diverse lineages in the developing embryo. However, spatiotemporally distinct NC populations display differences in fate potential, such as increased gliogenic and parasympathe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed594aa254e5e343e5d5a34952cb6cb5
https://doi.org/10.1101/2023.03.06.531220

Single-cell analyses of axolotl forebrain organization, neurogenesis, and regeneration

Autor: Katharina Lust, Ashley Maynard, Tomás Gomes, Jonas Simon Fleck, J. Gray Camp, Elly M. Tanaka, Barbara Treutlein

Salamanders are important tetrapod models to study brain organization and regeneration, however the identity and evolutionary conservation of brain cell types is largely unknown. Here, we delineate cell populations in the axolotl telencephalon during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02ca6d59b599b05eea428ac1abd21b9f
https://doi.org/10.1101/2022.03.21.485045

Lineage recording in human cerebral organoids

Autor: Zhisong He, Ashley Maynard, Akanksha Jain, Tobias Gerber, Rebecca Petri, Hsiu-Chuan Lin, Malgorzata Santel, Kevin Ly, Jean-Samuel Dupré, Leila Sidow, Fatima Sanchis Calleja, Sophie M. J. Jansen, Stephan Riesenberg, J. Gray Camp, Barbara Treutlein

Publikováno v: Nature Methods, 19 (1)
Nature Methods

Induced pluripotent stem cell (iPSC)-derived organoids provide models to study human organ development. Single-cell transcriptomics enable highly resolved descriptions of cell states within these systems; however, approaches are needed to directly me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25087fa2e4c1134a5fa52544a1dbc6e9
https://doi.org/10.3929/ethz-b-000524021

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Autor: Norma F. Neff, Jeanette Baran-Gale, Ashley Maynard, Fatima Dhalla, Rene Sit, Chris P. Ponting, AP May, Weilun Tan, Steven Chen, Foad Green, Georg A. Holländer, Morgan, Adam E. Handel, Stefano Maio, John C. Marioni, Spyros Darmanis, Mary E. Deadman, Irene Calvo-Asensio

Publikováno v: eLife
Baran-Gale, J, Morgan, M D, Maio, S, Dhalla, F, Calvo-Asensio, I, Deadman, M E, Handel, A E, Maynard, A, Chen, S, Green, F, Sit, R V, Neff, N F, Darmanis, S, Tan, W, May, A P, Marioni, J C, Ponting, C P & Holländer, G A 2020, ' Ageing compromises mouse thymus function and remodels epithelial cell differentiation ', eLIFE, vol. 9, no. 8, e56221 . https://doi.org/10.7554/eLife.56221
eLife, Vol 9 (2020)
eLife, 9

Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fc8a5ee53b84a3b59dd1f67e8e1170