Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Ashley Margol"'
Autor:
Katrina O’Halloran, Ashley Margol, Tom B. Davidson, Dolores Estrine, Benita Tamrazi, Jennifer A. Cotter, Jianling Ji, Jaclyn A. Biegel
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4882 (2024)
Medulloblastoma is the most common malignant brain tumor in childhood. Initial treatment generally includes surgery, irradiation, and chemotherapy. Approximately 20–30% of patients will experience a recurrence, which portends a very poor prognosis.
Externí odkaz:
https://doaj.org/article/254b7fe3518247e6ab2d43f789711006
Autor:
Elizabeth Alva, Jeffrey Rubens, Susan Chi, Tom Rosenberg, Alyssa Reddy, Eric H. Raabe, Ashley Margol
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 37, Iss , Pp 100880- (2023)
Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable,
Externí odkaz:
https://doaj.org/article/5c241990d0c5472da5a1d04fc2396d73
Autor:
Sukanya Iyer, Marwa Ismail, Benita Tamrazi, Ralph Salloum, Peter de Blank, Ashley Margol, Ramon Correa, Jonathan Chen, Kaustav Bera, Volodymyr Statsevych, Mai-Lan Ho, Pranjal Vaidya, Ruchika Verma, Debra Hawes, Alexander Judkins, Pingfu Fu, Anant Madabhushi, Pallavi Tiwari
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionMedulloblastoma (MB) is a malignant, heterogenous brain tumor. Advances in molecular profiling have led to identifying four molecular subgroups of MB (WNT, SHH, Group 3, Group 4), each with distinct clinical behaviors. We hypothesize that
Externí odkaz:
https://doaj.org/article/fa3bbee293b045198feb0c616919a64e
Autor:
Stewart Goldman, Ashley Margol, Eugene I. Hwang, Kazuhiro Tanaka, Bogdana Suchorska, John R. Crawford, Santosh Kesari
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
There is an unmet need to develop effective and tolerable treatments for pediatric patients with malignant central nervous system tumors. This is especially essential for pediatric patients with aggressive brain tumors such as high-grade gliomas, whi
Externí odkaz:
https://doaj.org/article/3d886f68a788431b80bb25f20dc8a574
Autor:
Jon Whitney, Liisa Dollinger, Benita Tamrazi, Debra Hawes, Marta Couce, Julia Marcheque, Alexander Judkins, Ashley Margol, Anant Madabhushi
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100090- (2022)
Molecular subtypes of medulloblastoma [Sonic Hedgehog (SHH), Wingless/INT (WNT), Group 3, and Group 4] are defined by common patterns of gene expression. These differential gene expression patterns appear to result in different histomorphology and pr
Externí odkaz:
https://doaj.org/article/c461043f2ed4490dacd70f9c997d03df
Autor:
Craig Erker, Martin Mynarek, Simon Bailey, Claire M. Mazewski, Lorena Baroni, Maura Massimino, Juliette Hukin, Dolly Aguilera, Andrea M. Cappellano, Vijay Ramaswamy, Alvaro Lassaletta, Sébastien Perreault, Cassie N. Kline, Revathi Rajagopal, George Michaiel, Michal Zapotocky, Vicente Santa-Maria Lopez, Andres Morales La Madrid, Chantel Cacciotti, Eric S. Sandler, Lindsey M. Hoffman, Darren Klawinski, Sara Khan, Ralph Salloum, Anna L. Hoppmann, Valérie Larouche, Kathleen Dorris, Helen Toledano, Stephen W. Gilheeney, Mohamed S. Abdelbaki, Beverly Wilson, Derek S. Tsang, Jeffrey Knipstein, Michal Yalon Oren, Shafqat Shah, Jeffrey C. Murray, Kevin F. Ginn, Zhihong J. Wang, Gudrun Fleischhack, Denise Obrecht, Svenja Tonn, Virginia L. Harrod, Kara Matheson, Bruce Crooks, Douglas R. Strother, Kenneth J. Cohen, Jordan R. Hansford, Sabine Mueller, Ashley Margol, Amar Gajjar, Girish Dhall, Jonathan L. Finlay, Paul A. Northcott, Stefan Rutkowski, Steven C. Clifford, Giles Robinson, Eric Bouffet, Lucie Lafay-Cousin
PURPOSE Infant and young childhood medulloblastoma (iMB) is usually treated without craniospinal irradiation (CSI) to avoid neurocognitive late effects. Unfortunately, many children relapse. The purpose of this study was to assess salvage strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1c84196b9b4ebe9f95cd02adcf4b70
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85151312540
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85151312540
Autor:
Rohan Bareja, Marwa Ismail, Douglas Martin, Ameya Nayate, Benita Tamrazi, Ralph Salloum, Ashley Margol, Alexander Judkins, Sukanya Iyer, Peter de Blank, Pallavi Tiwari
Publikováno v:
Neuro-Oncology. 24:vii185-vii186
PURPOSE Superior outcomes for medulloblastoma (MB) requires precise surgical resection which can be guided by tumor segmentation. We present the first attempt at automatic segmentation of MB tumors via a hierarchical transfer-learning model that (1)
Autor:
Micah Harris, Richard Graham, Andrea Cappellano, ashley margol, George Michaiel, John Crawford, Myrsini Ioakeim-Ioannidou, Joseph Stanek, Kevin Liu, shannon Macdonald, Mohamed Abdelbaki
Purpose: Primary germ cell tumors (GCTs) are the most common central nervous system (CNS) neoplasm in patients with Down syndrome (DS). However, a standard-of-care has not been established due to a paucity of data. Methods: A retrospective multi-inst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b54153a71f8eafe19f708ea8aefe0462
https://doi.org/10.22541/au.164966233.33052980/v1
https://doi.org/10.22541/au.164966233.33052980/v1
Autor:
Katrina O'Halloran, Sheetal Phadnis, Laura Metrock, Gregory Friedman, Tom Davidson, Nathan Robison, Girish Dhall, Ashley Margol
Publikováno v:
Neuro-Oncology. 24:i126-i127
Medulloblastoma is the most common malignant brain tumor of childhood. Despite multi-modal therapies, ~30% of patients experience disease recurrence, which portends a poor prognosis. At initial recurrence, intensive chemotherapy may be effective prio
Autor:
Nathan Robison, Jasmine Pauly, Jemily Malvar, Sharon Gardner, Jeffrey Allen, Ashley Margol, Tobey MacDonald, Anne Bendel, Lindsay Kilburn, Andrew Cluster, Daniel Bowers, Kathleen Dorris, Nicole Ullrich, Rebecca Loret De Mola, Elizabeth Alva, Sarah Leary, Patricia Baxter, Ziad Khatib, Kenneth Cohen, Tom Belle Davidson, Ashley Plant, Pratiti Bandopadhayay, Sylwia Stopka, Nathalie Agar, Karen Wright, Marvin Nelson, Yueh-Yun Chi, Mark Kieran
Publikováno v:
Neuro-Oncology. 24:i191-i192
BACKGROUND RAS/RAF/MEK/ERK pathway activation is the primary driver for most pediatric low-grade gliomas (pLGG). MEK162 (binimetinib) is an orally bioavailable MEK1/2 inhibitor with superior brain penetration in a preclinical model. The primary objec