Výsledky vyhledávání - "Ashley M. Wellendorf"

Akademický článek

Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo

Autor: Lisa R. Trump, Ramesh C. Nayak, Abhishek K. Singh, Sana Emberesh, Ashley M. Wellendorf, Carolyn M. Lutzko, Jose A. Cancelas

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 6, Pp 557-567 (2019)

Abstract Bacterial and fungal infections are a major cause of morbidity and mortality in neutropenic patients. Donor‐derived neutrophil transfusions have been used for prophylaxis or treatment for infection in neutropenic patients. However, the sho

Externí odkaz: https://doaj.org/article/83c7d1013fa14a0f8ad62c2c8893305e

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Akademický článek

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

Autor: Jing Fang, Tomoya Muto, Maria Kleppe, Lyndsey C. Bolanos, Kathleen M. Hueneman, Callum S. Walker, Leesa Sampson, Ashley M. Wellendorf, Kashish Chetal, Kwangmin Choi, Nathan Salomonis, Yongwon Choi, Yi Zheng, Jose A. Cancelas, Ross L. Levine, Daniel T. Starczynowski

Publikováno v: Cell Reports, Vol 22, Iss 5, Pp 1250-1262 (2018)

Summary: Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC) homeostasis in the absence of inflammation; however, the upstream mediators of basal NF-κB signaling are less well understood. Here, we describe TRAF

Externí odkaz: https://doaj.org/article/4daedec41a394d7e95b5498a1278e32b

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Akademický článek

p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-κB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche

Autor: Kyung Hee Chang, Amitava Sengupta, Ramesh C. Nayak, Angeles Duran, Sang Jun Lee, Ronald G. Pratt, Ashley M. Wellendorf, Sarah E. Hill, Marcus Watkins, Daniel Gonzalez-Nieto, Bruce J. Aronow, Daniel T. Starczynowski, Roberto Civitelli, Maria T. Diaz-Meco, Jorge Moscat, Jose A. Cancelas

Publikováno v: Cell Reports, Vol 9, Iss 6, Pp 2084-2097 (2014)

In the bone marrow (BM), hematopoietic progenitors (HPs) reside in specific anatomical niches near osteoblasts (Obs), macrophages (MΦs), and other cells forming the BM microenvironment. A connection between immunosurveillance and traffic of HP has b

Externí odkaz: https://doaj.org/article/61c03b893acd42ada2b3efb6cecf74d3

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Akademický článek

Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics

Autor: Juana Serrano-Lopez, Shailaja Hegde, Sachin Kumar, Josefina Serrano, Jing Fang, Ashley M Wellendorf, Paul A Roche, Yamileth Rangel, Leolene J Carrington, Hartmut Geiger, H Leighton Grimes, Sanjiv Luther, Ivan Maillard, Joaquin Sanchez-Garcia, Daniel T Starczynowski, Jose A Cancelas

Publikováno v: eLife, Vol 10 (2021)

Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emerge

Externí odkaz: https://doaj.org/article/08b4f0f9fe184ce5b3fbfcccc7aca175

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Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma

Autor: Tali Dadosh, Breanna Bohan, Hassan Massalha, Eman Khatib-Massalha, Ashley M Wellendorf, Abhishek Singh, Mruniya V. Gawali, Smadar Levin-Zaidman, Orit Kollet, Tsvee Lapidot, Ekaterina Petrovich-Kopitman, Karin Golan, Mark J Althoff, Jose A. Cancelas, Mayla Bertagna, Biplab Dasgupta

Publikováno v: Blood. 136:2607-2619

The fate of hematopoietic stem and progenitor cells (HSPC) is tightly regulated by their bone marrow (BM) microenvironment (ME). BM transplantation (BMT) frequently requires irradiation preconditioning to ablate endogenous hematopoietic cells. Whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6562a78bbb56baaa50dd4ff161eb2dd2
https://doi.org/10.1182/blood.2020005399

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Antioxidant prevents clearance of hemostatically competent platelets after long‐term cold storage

Autor: Shailaja Hegde, Jose A. Cancelas, Yi Zheng, Ashley M Wellendorf

Publikováno v: Transfusion

Background Cold storage of platelets (PLTs) has the potential advantage of prolonging storage time while reducing posttransfusion infection given the decreased likelihood of bacterial outgrowth during storage and possibly beneficial effects in treati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ee036b523b7eb6caa861c1acf9bbb1
https://doi.org/10.1111/trf.16200

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Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo

Autor: Abhishek Singh, Ramesh C. Nayak, Jose A. Cancelas, Carolyn Lutzko, Ashley M Wellendorf, Lisa Trump, Sana Emberesh

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 6, Pp 557-567 (2019)
Stem Cells Translational Medicine

Bacterial and fungal infections are a major cause of morbidity and mortality in neutropenic patients. Donor-derived neutrophil transfusions have been used for prophylaxis or treatment for infection in neutropenic patients. However, the short half-lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456e4cfc848f3296c275ffe53694f8e3
https://doi.org/10.1002/sctm.18-0255

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