P300 Crohn’s Disease Strictures Respond to Drug Treatment and Treat-to-Target Intense Combination Therapy is More Effective than Standard Anti-TNF Therapy. The STRIDENT Randomised Controlled Trial

Autor: Alyson L Ross, Julien D Schulberg, William Connell, Mark Lust, Ashley M. Miller, Bronte A. Holt, Amy L. Hamilton, Britt Christensen, Edward Shelton, T Sutherland, Nik S. Ding, Emily K Wright, S Vogrin, Sally Bell, Y Rong, P. De Cruz, Michael A. Kamm, Gregory T. Moore

Publikováno v: Journal of Crohn's and Colitis. 15:S328-S330

Background Strictures are the commonest complication in Crohn’s disease. Surgery and endoscopic dilation are the main treatments; drug therapy has been considered contra-indicated. Given that most strictures have an inflammatory component we aimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d50730334c18838f51c098826e65cb2
https://doi.org/10.1093/ecco-jcc/jjab076.424

Low failure to attend rates and increased clinic capacity with Telehealth: A highly effective outpatient model that should continue beyond the COVID-19 pandemic

Autor: Jacinta A Holmes, C. Croagh, J. Howell, E Tsoi, A Farrell, R. Shah, Timothy Papaluca, Suzanne E. Mahady, Thai Hong, Tanya Lee, Marno Ryan, Bronte A. Holt, Mark Lust, George Tambakis, Emily K Wright, M. Macisaac, William Connell, Michael A. Kamm, Chamara Basnayake, David Iser, B. Demediuk, Ashley M. Miller, Nik S. Ding, Alexander Jv Thompson

Publikováno v: Journal of Gastroenterology and Hepatology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b0206e1195bcbdb29e158a6cee4a64
https://pubmed.ncbi.nlm.nih.gov/33338284

Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes?

Autor: Ashley M Miller, David Purves, Alex McConnachie, Darren L Asquith, G David Batty, Harry Burns, Jonathan Cavanagh, Ian Ford, Jennifer S McLean, Chris J Packard, Paul G Shiels, Helen Turner, Yoga N Velupillai, Kevin A Deans, Paul Welsh, Iain B McInnes, Naveed Sattar

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47830 (2012)

Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease. However, the characterisation of s

Externí odkaz: https://doaj.org/article/7a5c789b2d594a97be013f7439da3359

Magnetic resonance enterography for predicting the clinical course of Crohn's disease strictures

Autor: Mark Lust, Michael A. Kamm, William C Connell, Bronte A. Holt, Steven J. Brown, Emily K Wright, Julien D Schulberg, Simon J Hume, Alyson L Ross, Sally Bell, Amy L. Hamilton, Tom Sutherland, Ashley M. Miller

Publikováno v: Journal of gastroenterology and hepatologyReferences. 35(6)

BACKGROUND AND AIMS: Strictures are the most common Crohn's disease complication, but their natural history is unknown. This study aimed to characterize inflammation, predict prognosis, and understand the impact of drug therapy using magnetic resonan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef08c6f60f607194f460d228f8590df5
https://pubmed.ncbi.nlm.nih.gov/31674069

Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein–Coupled Receptor 120

Autor: Ashley M. Miller, Andrew B. Tobin, Elisa Alvarez-Curto, Graeme Milligan, Brian D. Hudson, Rudi Prihandoko, Adrian J. Butcher, Trond Ulven

Publikováno v: Prihandoko, R, Alvarez-Curto, E, Hudson, B D, Butcher, A J, Ulven, T, Miller, A M, Tobin, A B & Milligan, G 2016, ' Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120 ', Molecular Pharmacology, vol. 89, no. 5, pp. 505-520 . https://doi.org/10.1124/mol.115.101949

It is established that long-chain free fatty acids includingω-3 fatty acids mediate an array of biologic responses through members of the free fatty acid (FFA) receptor family, which includes FFA4. However, the signaling mechanisms and modes of regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cda8179e19e3e11119d80ba3839917d
https://doi.org/10.1124/mol.115.101949