Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ashley M Lakner"'
Autor:
Whitney M Ellefson, Ashley M Lakner, Alicia Hamilton, Iain H McKillop, Herbert L Bonkovsky, Nury M Steuerwald, Yvette M Huet, Laura W Schrum
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29463 (2011)
Alcoholic liver disease (ALD) affects millions of people worldwide and is a major cause of morbidity and mortality. However, fewer than 10% of heavy drinkers progress to later stages of injury, suggesting other factors in ALD development, including e
Externí odkaz:
https://doaj.org/article/f0d82ca587d74f7da0fcf2dd4008026e
Autor:
Richard A. Rippe, Brian W. Cross, Iain H. McKillop, Shigeki Tsukada, Laura W. Schrum, Ashley M. Lakner, Kyle J. Thompson
Publikováno v:
Liver International. 31:891-901
Background: Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) components that disrupt normal liver microcirculation and lead to organ injury. Hepatic stellate cells (HSCs), following transdifferentiation, are the central medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d019359680f6baeb6195ee4cc60abbf6
https://doi.org/10.1111/j.1478-3231.2011.02512.x
https://doi.org/10.1111/j.1478-3231.2011.02512.x
Publikováno v:
Liver International. 31:42-51
Background: Hepatic stellate cells (HSCs) are effector cells of hepatic fibrosis contributing to excessive collagen deposition and scar matrix formation. Sustained HSC activation leads to hepatic cirrhosis, a leading cause of liver-related death. Rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07f2b56a0190e4bd245219c1cf50bceb
https://doi.org/10.1111/j.1478-3231.2010.02356.x
https://doi.org/10.1111/j.1478-3231.2010.02356.x
Publikováno v:
Hepatology (Baltimore, Md.). 57(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07a4bb45b4ef968fbb002e72c3a880e9
https://pubmed.ncbi.nlm.nih.gov/22815191
https://pubmed.ncbi.nlm.nih.gov/22815191
Autor:
Ting Li, Nury Steuerwald, Sriparna Ghosh, Laura W. Schrum, Tracy L. Walling, Herbert L. Bonkovsky, Mark W. Russo, Iain H. McKillop, Ashley M. Lakner
Hepatic stellate cell (HSC) activation is a pivotal event in initiation and progression of hepatic fibrosis and a major contributor to collagen deposition driven by transforming growth factor beta (TGFβ). microRNAs (miRs), small non-coding RNAs modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15db89d199baad7e7c1807b095eca0c
https://europepmc.org/articles/PMC3342471/
https://europepmc.org/articles/PMC3342471/
Autor:
Kyle J, Thompson, Ashley M, Lakner, Brian W, Cross, Shigeki, Tsukada, Richard A, Rippe, Iain H, McKillop, Laura W, Schrum
Publikováno v:
Liver international : official journal of the International Association for the Study of the Liver. 31(6)
Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) components that disrupt normal liver microcirculation and lead to organ injury. Hepatic stellate cells (HSCs), following transdifferentiation, are the central mediators of hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2dccb1463571a8c2d5b3a0532d610deb
https://pubmed.ncbi.nlm.nih.gov/21645221
https://pubmed.ncbi.nlm.nih.gov/21645221
Autor:
Nury M Steuerwald, Laura W Schrum, Whitney M Ellefson, Ashley M Lakner, Judith C Parsons, Alicia T Hamilton, Iain H McKillop, Herbert L Bonkovsky, Yvette M Huet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64a64b050768c6e88c457def9142d1e5
https://doi.org/10.1210/endo-meetings.2011.part3.p21.p3-81
https://doi.org/10.1210/endo-meetings.2011.part3.p21.p3-81
microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of all human transcripts and are kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6e1a032b088f95e977ae941e459a4f
Autor:
Mao-Hsiung Yen, Ashley M. Lakner, Edwin S. C. Wu, Mark G. Clemens, Laura W. Schrum, Stephani A. Day, Cathy C. Moore
Publikováno v:
Biochemical pharmacology. 81(8)
Hepatic fibrosis is characterized by excess type I collagen deposition and exacerbated inflammatory response. Naltrexone, an opioid receptor antagonist used for treating alcohol abuse, attenuates hepatocellular injury in fibrotic animal models, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf8f41552840ce2b63f0d21b373455b
https://pubmed.ncbi.nlm.nih.gov/21291870
https://pubmed.ncbi.nlm.nih.gov/21291870
Publikováno v:
Liver international : official journal of the International Association for the Study of the Liver. 31(1)
Hepatic stellate cells (HSCs) are effector cells of hepatic fibrosis contributing to excessive collagen deposition and scar matrix formation. Sustained HSC activation leads to hepatic cirrhosis, a leading cause of liver-related death. Reversal of hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73f74c11846f5b2df264e4c7367e55fc
https://pubmed.ncbi.nlm.nih.gov/20958918
https://pubmed.ncbi.nlm.nih.gov/20958918