Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ashley M Curran"'
Autor:
Jonathan D. Crawford, Hong Wang, Daniela Trejo-Zambrano, Raffaello Cimbro, C. Conover Talbot Jr., Mekha A. Thomas, Ashley M. Curran, Alexander A. Girgis, John T. Schroeder, Andrea Fava, Daniel W. Goldman, Michelle Petri, Antony Rosen, Brendan Antiochos, Erika Darrah
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a dramatic sex bias, affecting 9 times more women than men. Activation of Toll-like receptor 7 (TLR7) by self-RNA is a central pathogenic process leading to aberrant production
Externí odkaz:
https://doaj.org/article/c0371d9e64444ee9b80751b28fb3f9cd
Autor:
Ashley M. Curran, Alexander A. Girgis, Yura Jang, Jonathan D. Crawford, Mekha A. Thomas, Ryan Kawalerski, Jeff Coller, Clifton O. Bingham, Chan Hyun Na, Erika Darrah
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Antibodies directed against citrullinated proteins are commonly found in patients with rheumatoid arthritis. Here, the authors show that citrullination alters the peptide repertoire presented to T cells by altering protease cleavage and inducing prot
Externí odkaz:
https://doaj.org/article/167ebce599e34f1fa373394b0186f854
Autor:
Jon T. Giles, Ashley M. Curran, Pooja Naik, Felipe Andrade, Ruiqiang Chen, Chan Hyun Na, Ryan L. Davis, Erika Darrah
Publikováno v:
Arthritis Rheumatol
OBJECTIVE Citrullinated proteins are hallmark targets of autoantibodies in rheumatoid arthritis (RA). Our study was undertaken to determine the effect of autocitrullination on the recognition of peptidylarginine deiminases (PADs) 2 and 4 by autoantib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee7db06c9f02c914b08025aad1512ca
https://doi.org/10.1002/art.41276
https://doi.org/10.1002/art.41276
Publikováno v:
Nature Reviews Rheumatology. 16:301-315
Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins - the hallmark autoantigens of RA. Of the five PAD enzyme isoforms, PAD2 and PAD4 are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::932a763c965e30104c7386eb00521109
https://doi.org/10.1038/s41584-020-0409-1
https://doi.org/10.1038/s41584-020-0409-1
Autor:
Ashley M Curran, Yura Jang, Mekha A. Thomas, Alexander A. Girgis, Jonathan D. Crawford, Robert N. O’Meally, Robert N. Cole, Chan Hyun Na, Erika Darrah
Publikováno v:
The Journal of Immunology. 208:102.04-102.04
Cryptic peptides, hidden from the immune system under physiologic conditions, are revealed by changes to MHC class II processing and can facilitate loss of tolerance to self-antigens. Rheumatoid arthritis (RA) is a chronic autoimmune disease characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d541ad52408e1b75e9f5f3593e539691
https://doi.org/10.4049/jimmunol.208.supp.102.04
https://doi.org/10.4049/jimmunol.208.supp.102.04
Autor:
Jonathan D Crawford, Hong Wang, C. Conover Talbot, Ashley M Curran, Daniel W. Goldman, Michelle Petri, Brendan Antiochos, Erika Darrah
Publikováno v:
The Journal of Immunology. 208:108.02-108.02
Systemic Lupus Erythematosus (SLE) is among the most sex-biased autoimmune diseases identified to date, affecting 9-times more women than men. Recognition of self-RNA by Toll-like receptor 7 (TLR7) is implicated as a central pathogenic process leadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63fc34968fdcc8dff61aa69ab362c369
https://doi.org/10.4049/jimmunol.208.supp.108.02
https://doi.org/10.4049/jimmunol.208.supp.108.02
Autor:
Mekha A Thomas, Pooja Naik, Hong Wang, Yura Jang, Tory P Johnson, Ashley M Curran, Jonathan D Crawford, Shaghayegh Jahanbani, William H Robinson, Chan Hyun Na, Erika Darrah
Publikováno v:
The Journal of Immunology. 208:104.01-104.01
Citrullination is recognized as a key pathogenic process in rheumatoid arthritis (RA), as evidenced by the formation of anti-citrullinated protein antibodies (APCAs) in the majority of patients; however, the mechanisms that result in citrullinated au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::778bc61e2bd6d551d8930d4c6df79c6b
https://doi.org/10.4049/jimmunol.208.supp.104.01
https://doi.org/10.4049/jimmunol.208.supp.104.01