Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Ashley M Buckle"'
Autor:
Xingchen Chen, Blake T Riley, Simon J de Veer, David E Hoke, Jessica Van Haeften, Darren Leahy, Joakim E Swedberg, Maria Brattsand, Perry J Hartfield, Ashley M Buckle, Jonathan M Harris
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210842 (2019)
Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski mechanism inhibitors that present a substrate-like loop to a target protease. This loop is
Externí odkaz:
https://doaj.org/article/ff0580b312cb47f5b9a6eca710bfcd0a
Autor:
Sarah N Le, Benjamin T Porebski, Julia McCoey, James Fodor, Blake Riley, Marlena Godlewska, Monika Góra, Barbara Czarnocka, J Paul Banga, David E Hoke, Itamar Kass, Ashley M Buckle
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0142615 (2015)
Thyroid peroxidase (TPO) catalyses the biosynthesis of thyroid hormones and is a major autoantigen in Hashimoto's disease--the most common organ-specific autoimmune disease. Epitope mapping studies have shown that the autoimmune response to TPO is di
Externí odkaz:
https://doaj.org/article/4b2bc99a9c1a4ce2b00e1f925ee7cc79
Autor:
Blake T Riley, Sebastian S Broendum, Cyril F Reboul, Nathan P Cowieson, Mauricio G S Costa, Itamar Kass, Colin Jackson, David Perahia, Ashley M Buckle, Sheena McGowan
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140219 (2015)
The growing problem of antibiotic resistance underlies the critical need to develop new treatments to prevent and control resistant bacterial infection. Exogenous application of bacteriophage lysins results in rapid and specific destruction of Gram-p
Externí odkaz:
https://doaj.org/article/cdbca4d9d511430e9514547cbd529bd8
Autor:
Sarah C Atkinson, Con Dogovski, Matthew T Downton, F Grant Pearce, Cyril F Reboul, Ashley M Buckle, Juliet A Gerrard, Renwick C J Dobson, John Wagner, Matthew A Perugini
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38318 (2012)
Dihydrodipicolinate synthase (DHDPS) catalyzes the rate limiting step in lysine biosynthesis in bacteria and plants. The structure of DHDPS has been determined from several bacterial species and shown in most cases to form a homotetramer or dimer of
Externí odkaz:
https://doaj.org/article/fd29a4c895724e209e09c54f98419d8e
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 3, p e1002404 (2012)
The crystal structures of unliganded and liganded pMHC molecules provide a structural basis for TCR recognition yet they represent 'snapshots' and offer limited insight into dynamics that may be important for interaction and T cell activation. MHC mo
Externí odkaz:
https://doaj.org/article/60458ce1470a4a628c2eae43320d37f5
Autor:
Bindu Jayakrishnan, David E Hoke, Christopher G Langendorf, Ashley M Buckle, Merrill J Rowley
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18411 (2011)
BACKGROUND: Autoantibodies to GAD65 (anti-GAD65) are present in the sera of 70-80% of patients with type 1 diabetes (T1D), but antibodies to the structurally similar 67 kDa isoform GAD67 are rare. Antibodies to GAD67 may represent a cross-reactive po
Externí odkaz:
https://doaj.org/article/0a4ddd543c9146349f226f406790a15d
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18981 (2011)
BACKGROUND: The C-terminal domain of MotB (MotB-C) shows high sequence similarity to outer membrane protein A and related peptidoglycan (PG)-binding proteins. It is believed to anchor the power-generating MotA/MotB stator unit of the bacterial flagel
Externí odkaz:
https://doaj.org/article/1c7b356254944b38a70a4789e04a429a
Autor:
Joakim E Swedberg, Simon J de Veer, Kei C Sit, Cyril F Reboul, Ashley M Buckle, Jonathan M Harris
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19302 (2011)
BACKGROUND: Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s). The smallest of these is sunflower trypsin inhibitor (SFTI-1), a potent and br
Externí odkaz:
https://doaj.org/article/50c0a0c2cf3449b7b64f8c36d6b93a8a
Autor:
Christopher G Langendorf, Trevor L G Key, Gustavo Fenalti, Wan-Ting Kan, Ashley M Buckle, Tom Caradoc-Davies, Kellie L Tuck, Ruby H P Law, James C Whisstock
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9280 (2010)
BackgroundIn mammals succinic semialdehyde dehydrogenase (SSADH) plays an essential role in the metabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) to succinic acid (SA). Deficiency of SSADH in humans results in elevated leve
Externí odkaz:
https://doaj.org/article/a516366723734c67a8727a844c5aaebb
Autor:
Claude Nogues, Hervé Leh, Christopher G Langendorf, Ruby H P Law, Ashley M Buckle, Malcolm Buckle
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12152 (2010)
BACKGROUND: Non-specific binding to biosensor surfaces is a major obstacle to quantitative analysis of selective retention of analytes at immobilized target molecules. Although a range of chemical antifouling monolayers has been developed to address
Externí odkaz:
https://doaj.org/article/32a678fe0a2f4f5c9b09c606ac5424d5