Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Ashley M, Vaughan"'
Autor:
Debashree Goswami, Silvia A. Arredondo, William Betz, Janna Armstrong, Sudhir Kumar, Gigliola Zanghi, Hardik Patel, Nelly Camargo, Kenza M. Z. Oualim, Annette M. Seilie, Sophia Schneider, Sean C. Murphy, Stefan H. I. Kappe, Ashley M. Vaughan
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Malaria, caused by Plasmodium parasites, imposes a significant health burden and live-attenuated parasites are being pursued as vaccines. Here, we report on the creation of a genetically attenuated parasite by the deletion of Plasmodium LINU
Externí odkaz:
https://doaj.org/article/07a3fd59e30b49d29f842e336ca76cb4
Autor:
Debashree Goswami, Hardik Patel, William Betz, Janna Armstrong, Nelly Camargo, Asha Patil, Sumana Chakravarty, Sean C Murphy, B Kim Lee Sim, Ashley M Vaughan, Stephen L Hoffman, Stefan HI Kappe
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 723-754 (2024)
Abstract Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection when compared to vaccination with replication-deficient, ra
Externí odkaz:
https://doaj.org/article/2fcc440695074e599b621cd9032c9199
Autor:
John Kane, Xue Li, Sudhir Kumar, Katrina A. Button-Simons, Katelyn M. Vendrely Brenneman, Haley Dahlhoff, Mackenzie A. C. Sievert, Lisa A. Checkley, Douglas A. Shoue, Puspendra P. Singh, Biley A. Abatiyow, Meseret T. Haile, Shalini Nair, Ann Reyes, Rupam Tripura, Thomas J. Peto, Dysoley Lek, Angana Mukherjee, Stefan H. I. Kappe, Mehul Dhorda, Standwell C. Nkhoma, Ian H. Cheeseman, Ashley M. Vaughan, Timothy J. C. Anderson, Michael T. Ferdig
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Piperaquine (PPQ) is widely used in combination with dihydroartemisinin as a first-line treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the Plasmodium falciparum chloroquine re
Externí odkaz:
https://doaj.org/article/b191e5641f084dea867745f9b4a6c1b8
Autor:
Thomas L. Richie, L.W. Preston Church, Tooba Murshedkar, Peter F. Billingsley, Eric R. James, Mei-Chun Chen, Yonas Abebe, Natasha KC, Sumana Chakravarty, David Dolberg, Sara A. Healy, Halimatou Diawara, Mahamadou S. Sissoko, Issaka Sagara, David M. Cook, Judith E. Epstein, Benjamin Mordmüller, Melissa Kapulu, Andrea Kreidenweiss, Blandine Franke-Fayard, Selidji T. Agnandji, María-Silvia A. López Mikue, Matthew B.B. McCall, Laura Steinhardt, Martina Oneko, Ally Olotu, Ashley M. Vaughan, James G. Kublin, Sean C. Murphy, Said Jongo, Marcel Tanner, Sodiomon B. Sirima, Matthew B. Laurens, Claudia Daubenberger, Joana C. Silva, Kirsten E. Lyke, Chris J. Janse, Meta Roestenberg, Robert W. Sauerwein, Salim Abdulla, Alassane Dicko, Stefan H. I. Kappe, B. Kim Lee Sim, Patrick E. Duffy, Peter G. Kremsner, Stephen L. Hoffman
Publikováno v:
Expert Review of Vaccines, Vol 0, Iss 0 (2023)
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especi
Externí odkaz:
https://doaj.org/article/64ccc130995e4fbda0570808ef7ca47d
Autor:
Sudhir Kumar, Vinay K. Baranwal, Amanda S. Leeb, Meseret T. Haile, Kenza M. Z. Oualim, Nina Hertoghs, Ashley M. Vaughan, Stefan H. I. Kappe
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Serine/arginine-rich protein kinases (SRPKs) are cell cycle-regulated serine/threonine protein kinases and are important regulators of splicing factors. In this study, we functionally characterize SRPK1 of the human malaria parasite Plasmodi
Externí odkaz:
https://doaj.org/article/4870a2fb2a6b40989c8cce65bae79629
Autor:
Katrina A. Button-Simons, Sudhir Kumar, Nelly Carmago, Meseret T. Haile, Catherine Jett, Lisa A. Checkley, Spencer Y. Kennedy, Richard S. Pinapati, Douglas A. Shoue, Marina McDew-White, Xue Li, François H. Nosten, Stefan H. Kappe, Timothy J. C. Anderson, Jeanne Romero-Severson, Michael T. Ferdig, Scott J. Emrich, Ashley M. Vaughan, Ian H. Cheeseman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Button-Simons et al. report on two different genetic crosses of Plasmodium falciparum derived from Asian and African origin parasites, and generate large numbers of recombinant progeny. These crosses are characterized and have the potential to map bi
Externí odkaz:
https://doaj.org/article/4b96c353972642afa3c35313f59f6b9c
Autor:
Sudhir Kumar, Vinay K. Baranwal, Meseret T. Haile, Kenza M. Z. Oualim, Biley A. Abatiyow, Spencer Y. Kennedy, Ashley M. Vaughan, Stefan H. I. Kappe
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Sexual reproduction of Plasmodium falciparum parasites is critical to the spread of malaria in the human population. The factors that regulate gene expression underlying formation of fertilization-competent gametes, however, remain unknown.
Externí odkaz:
https://doaj.org/article/96f216594a5d47c48d709ad84cd9f084
Autor:
Sudhir Kumar, Xue Li, Marina McDew-White, Ann Reyes, Elizabeth Delgado, Abeer Sayeed, Meseret T. Haile, Biley A. Abatiyow, Spencer Y. Kennedy, Nelly Camargo, Lisa A. Checkley, Katelyn V. Brenneman, Katrina A. Button-Simons, Manoj T. Duraisingh, Ian H. Cheeseman, Stefan H. I. Kappe, François Nosten, Michael T. Ferdig, Ashley M. Vaughan, Tim J. C. Anderson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
What genes determine in vitro growth and nutrient utilization in asexual blood-stage malaria parasites? Competition experiments between NF54, clone 3D7, a lab-adapted African parasite, and a recently isolated Asian parasite (NHP4026) reveal contrasti
Externí odkaz:
https://doaj.org/article/f1770635606e4ad9b9e38fc02d8a9d7e
Autor:
Debashree Goswami, Sudhir Kumar, William Betz, Janna M. Armstrong, Meseret T. Haile, Nelly Camargo, Chaitra Parthiban, Annette M. Seilie, Sean C. Murphy, Ashley M. Vaughan, Stefan H.I. Kappe
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104224- (2022)
Summary: Plasmodium sporozoites invade hepatocytes and transform into liver stages within a parasitophorous vacuole (PV). The parasites then grow and replicate their genome to form exoerythrocytic merozoites that infect red blood cells. We report tha
Externí odkaz:
https://doaj.org/article/d187e3ed4dea4a7b8d174e3f0269d944
Autor:
Katelyn Vendrely Brenneman, Xue Li, Sudhir Kumar, Elizabeth Delgado, Lisa A. Checkley, Douglas A. Shoue, Ann Reyes, Biley A. Abatiyow, Meseret T. Haile, Rupam Tripura, Tom Peto, Dysoley Lek, Katrina A. Button-Simons, Stefan H.I. Kappe, Mehul Dhorda, François Nosten, Standwell C. Nkhoma, Ian H. Cheeseman, Ashley M. Vaughan, Michael T. Ferdig, Tim J.C. Anderson
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104095- (2022)
Summary: Classical malaria parasite genetic crosses involve isolation, genotyping, and phenotyping of progeny parasites, which is time consuming and laborious. We tested a rapid alternative approach—bulk segregant analysis (BSA)—that utilizes seq
Externí odkaz:
https://doaj.org/article/92955e99b1f54ae581be8c1979028447