Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ashley Kuenzi Davis"'
Autor:
Hua He, Sheila M. Bell, Ashley Kuenzi Davis, Shuyang Zhao, Anusha Sridharan, Cheng-Lun Na, Minzhe Guo, Yan Xu, John Snowball, Daniel T. Swarr, William J. Zacharias, Jeffrey A. Whitsett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract While the critical role of NKX2-1 and its transcriptional targets in lung morphogenesis and pulmonary epithelial cell differentiation is increasingly known, mechanisms by which chromatin accessibility alters the epigenetic landscape and how
Externí odkaz:
https://doaj.org/article/79cd3e157e724b03a2d39b4dd9536a17
Autor:
Yuan Li, Yi Zheng, Phuong Nguyen, Ting Wen, Anil G Jegga, Khalid W Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Fukun Guo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Cancer immunotherapy has taken center stage in cancer treatment. However, the current immunotherapies only benefit a small proportion of patients with cancer, necessitating better understanding of the mechanisms of tumor immune evasion and
Externí odkaz:
https://doaj.org/article/0a852aedcfe146eb8f5e7e1f97e9c4cf
Autor:
Xin Duan, Rehana Perveen, Akhila Dandamudi, Reheman Adili, James Johnson, Kevin Funk, Mark Berryman, Ashley Kuenzi Davis, Michael Holinstat, Yi Zheng, Huzoor Akbar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Gene targeting of Cdc42 GTPase has been shown to inhibit platelet activation. In this study, we investigated a hypothesis that inhibition of Cdc42 activity by CASIN, a small molecule Cdc42 Activity-Specific INhibitor, may down regulate plate
Externí odkaz:
https://doaj.org/article/4e0ab58442d54fbc9bafc38cdf9a72ae
Autor:
Ming Liu, Zheng Zhang, Leesa Sampson, Xuan Zhou, Kodandaramireddy Nalapareddy, Yuxin Feng, Shailaja Akunuru, Jaime Melendez, Ashley Kuenzi Davis, Feng Bi, Hartmut Geiger, Mei Xin, Yi Zheng
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1961-1975 (2017)
Summary: RHOA, a founding member of the Rho GTPase family, is critical for actomyosin dynamics, polarity, and morphogenesis in response to developmental cues, mechanical stress, and inflammation. In murine small intestinal epithelium, inducible RHOA
Externí odkaz:
https://doaj.org/article/1153bd8c5202450e98fe432b2de8460f
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127923 (2015)
Numerous cellular studies have indicated that RhoA signaling is required for oncogenic Ras-induced transformation, suggesting that RhoA is a useful target in Ras induced neoplasia. However, to date very limited data exist to genetically attribute Rho
Externí odkaz:
https://doaj.org/article/a88e5b1d32994b24b7f2c3c029a36b2e
Autor:
Chen Wang, Zhaowei Tu, Xiongwei Cai, Weinan Wang, Ashley Kuenzi Davis, Kalpana J Nattamai, Aditi Paranjpe, Phillip Dexheimer, Jianqiang Wu, L. Frank Huang, Hartmut Geiger, Gang Huang, Yi Zheng
Publikováno v:
Blood Advances.
As a member of the RUNT domain family core-binding transcription factors, RUNX1 is crucial for multiple stages of hematopoiesis and its mutation can cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). Previous wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70609746e332af2ff404b57714158468
https://doi.org/10.1182/bloodadvances.2022008591
https://doi.org/10.1182/bloodadvances.2022008591
Autor:
Khalid W Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G Jegga, Yi Zheng, Fukun Guo
Publikováno v:
Journal for immunotherapy of cancer. 10(11)
BackgroundCancer immunotherapy has taken center stage in cancer treatment. However, the current immunotherapies only benefit a small proportion of patients with cancer, necessitating better understanding of the mechanisms of tumor immune evasion and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc5df94cdb259e4986dd2fa72819b33
https://pubmed.ncbi.nlm.nih.gov/36427906
https://pubmed.ncbi.nlm.nih.gov/36427906
Autor:
Ashley Kuenzi Davis, Reheman Adili, Mark Berryman, James F. Johnson, Michael Holinstat, Rehana Perveen, Xin Duan, Kevin Funk, Huzoor Akbar, Yi Zheng, Akhila Dandamudi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Gene targeting of Cdc42 GTPase has been shown to inhibit platelet activation. In this study, we investigated a hypothesis that inhibition of Cdc42 activity by CASIN, a small molecule Cdc42 Activity-Specific INhibitor, may down regulate platelet activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51c98e03ebf729411e0e869a5885f04
https://doi.org/10.1038/s41598-021-92654-6
https://doi.org/10.1038/s41598-021-92654-6
Autor:
Zhaowei Tu, Chuntao Zhao, Mei Xin, Ashley Kuenzi Davis, Richard Lu, Yi Zheng, Mengwen Hu, Chen Wang
Publikováno v:
Blood
The Chd8 gene encodes a member of the chromodomain helicase DNA-binding (CHD) family of SNF2H-like adenosine triphosphate (ATP)-dependent chromatin remodeler, the mutations of which define a subtype of autism spectrum disorders. Increasing evidence f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc188973c22e7c1febf69dad3233ec2
https://doi.org/10.1182/blood.2020009997
https://doi.org/10.1182/blood.2020009997
Publikováno v:
Cell reports. 38(2)
Epithelial polarity is controlled by a polarity machinery that includes Rho GTPase CDC42 and Scribble/PAR. By using intestinal stem cell (ISC)-specific deletion of CDC42 in olfactomedin-4 (Olfm4)-internal ribosome entry site (IRES)-EGFP/CreERT2;CDC42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21ab006252dfeb88d0ad2991bcddb95
https://pubmed.ncbi.nlm.nih.gov/35021092
https://pubmed.ncbi.nlm.nih.gov/35021092