Kisspeptin Is Upregulated at the Maternal-Fetal Interface of the Preeclamptic-like BPH/5 Mouse and Normalized after Synchronization of Sex Steroid Hormones

Autor: Viviane C. L. Gomes, Ashley K. Woods, Kassandra R. Crissman, Camille A. Landry, Kalie F. Beckers, Bryce M. Gilbert, Lucas R. Ferro, Chin-Chi Liu, Erin L. Oberhaus, Jenny L. Sones

Publikováno v: Reproductive Medicine, Vol 3, Iss 4, Pp 263-279 (2022)

Insufficient invasion of conceptus-derived trophoblast cells in the maternal decidua is a key event in the development of early-onset preeclampsia (PE), a subtype of PE associated with high maternal and fetal morbidity and mortality. Kisspeptins, a f

Externí odkaz: https://doaj.org/article/fc76955eb4454cf69b6c68d467b38fc8

Abstract 104: Kisspeptin Signaling And Pregnancy Outcomes Are Ameliorated In The Preeclamptic-like BPH/5 Mouse After Synchronization Of Sex Steroid Hormones

Autor: Viviane C Gomes, Ashley K Woods, Camille A Landry, Kassandra R Crissman, Jennifer L Sones

Publikováno v: Hypertension. 79

Kisspeptins (KP), encoded by Kiss1 , are reported to play a role in early-onset preeclampsia (ePE), a life-threatening hypertensive disorder of pregnancy. KP is higher in term ePE placentae than in normal pregnancies. However, the role of KP in PE ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4eba556b0b3a623a378f75e829a5b15f
https://doi.org/10.1161/hyp.79.suppl_1.104

Artificial Synchronization of Sex Steroid Hormones Normalizes Kisspeptin Expression and Placentation in the Preeclamptic‐Like BPH/5 Mouse

Autor: Viviane C. Gomes, Ashley K. Woods, Camille A. Landry, Jennifer L. Sones

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::feec18965755c4c58a919d9e065ea4ac
https://doi.org/10.1096/fasebj.2022.36.s1.r6337

New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-Steatotic Properties in Mice

Autor: Weijun Shen, Vân T B Nguyen-Tran, David Huang, Zaid Amso, Peng-Yu Yang, Candy Lee, Huafei Zou, Ashley K. Woods, Peter G. Schultz

Publikováno v: Bioconjugate Chemistry. 31:1167-1176

Oxyntomodulin (OXM) is an intestinal peptide hormone that activates both glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptors. The natural peptide reduces body weight in obese subjects and exhibits direct acute glucoregulatory effects in pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f736b2f9eb7492a8a522c7df8c00672
https://doi.org/10.1021/acs.bioconjchem.0c00093

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models

Autor: Christina A. Bulman, Laura Chappell, Brenda T. Beerntsen, Nancy Tricoche, Judy A. Sakanari, Achim Hoerauf, Mark J. Taylor, Marianne Koschel, Denis Voronin, Stefan J. Frohberger, Emma L. Gunderson, Case W. McNamara, Joseph D. Turner, K. C. Lim, Marc P. Hübner, Victor Chi, Alexandra Ehrens, Andrew Steven, William J. Sullivan, Sara Lustigman, H. Michael Petrassi, Ian Vogel, Malina A. Bakowski, Martina Fendler, Ashley K. Woods

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
International Journal for Parasitology: Drugs and Drug Resistance, Vol 12, Iss, Pp 18-27 (2020)

The quinazolines CBR417 and CBR490 were previously shown to be potent anti-wolbachials that deplete Wolbachia endosymbionts of filarial nematodes and present promising pre-clinical candidates for human filarial diseases such as onchocerciasis. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66273d5039834f02f3e24bff74bd7c66
http://europepmc.org/articles/PMC6931063