Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ashley J. Russo"'
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112171- (2023)
Summary: Macrophages facilitate critical functions in regulating pathogen clearance and immune homeostasis in tissues. The remarkable functional diversity exhibited by macrophage subsets is dependent on tissue environment and the nature of the pathol
Externí odkaz:
https://doaj.org/article/afaf058c67f149a2be6113b40dc70e6e
Autor:
Swathy O. Vasudevan, Ashley J. Russo, Puja Kumari, Sivapriya Kailasan Vanaja, Vijay A. Rathinam
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110755- (2022)
Summary: Intracellular lipopolysaccharide (LPS) sensing by the noncanonical inflammasome comprising caspase-4 or -11 governs antibacterial host defense. How LPS gains intracellular access in vivo is largely unknown. Here, we show that CD14—an LPS-b
Externí odkaz:
https://doaj.org/article/40986afb7b1244eabc1735f82891d6db
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109012- (2021)
Summary: Caspase-11 sensing of intracellular lipopolysaccharide (LPS) plays critical roles during infections and sepsis. However, the key cell types that sense intracellular LPS and their contributions to the host responses at the organismal level ar
Externí odkaz:
https://doaj.org/article/27b0c47d86434abc9477ce596fec8298
Autor:
Chengliang Wang, Puja Kumari, Chuan Li, Gabriel A. Rabinovich, Margaret M. Fettis, Sachin D. Deshmukh, Arun Wanchoo, Anthony T. Vella, Shivalee Duduskar, Gregory A. Hudalla, Christoph Sponholz, Beiyan Zhou, Michael Bauer, Ashley J. Russo, Renjie Liu, Vijay A. K. Rathinam, Santiago P. Méndez-Huergo, Jianbin Ruan, Sivapriya Kailasan Vanaja, Juan M. Pérez Sáez, Karthik Chandiran, Swathy O. Vasudevan, Antoine Ménoret
Publikováno v:
Nat Immunol
Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and the concurrent release of damage-associated molecular patterns (DAMPs). Collectively, DAMPs are key determinants that shape the aftermath of inflammatory cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd368de112bdf46f79b07a7aa7e0a0d
https://doi.org/10.1038/s41590-020-00844-7
https://doi.org/10.1038/s41590-020-00844-7
Autor:
Jianbin Ruan, Sivapriya Kailasan Vanaja, Morena S. Havira, Chengliang Wang, Ashley J. Russo, Atri Ta, Vijay A. K. Rathinam, Puja Kumari
Publikováno v:
Sci Immunol
Inflammatory caspase-dependent cytosolic lipopolysaccharide (LPS) sensing is a critical arm of host defense against bacteria. How pathogens overcome this pathway to establish infections is largely unknown. Enterohemorrhagic Escherichia coli (EHEC) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18b4ed6df4d8c2967f6dc3a4208ebba
https://doi.org/10.1126/sciimmunol.abc0217
https://doi.org/10.1126/sciimmunol.abc0217
Publikováno v:
Immunol Rev
Nucleic acid sensing is a critical mechanism by which the immune system monitors for pathogen invasion. A set of germline-encoded innate immune receptors detect microbial DNA in various compartments of the cell, such as endosomes, the cytosol, and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b736d31417eb6b9c33fe92f66dd3925
https://pubmed.ncbi.nlm.nih.gov/32713036
https://pubmed.ncbi.nlm.nih.gov/32713036
Autor:
Sunita Patel-Hett, Douglas Lazarus, Christian G. Peters, Amanda Leung, Sayaka Masuko, Dora E Kohnke, Lindsay Tomczak, Angelique Meredith, Brad Dykstra, Marcus Lehmann, Silvia Giannini, Dean Falb, Ryan Carpenter, Po-Shun Lee, Sophia Pete, Ashley J Russo
Publikováno v:
Blood. 138:1001-1001
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts ( Current treatment strategies for ITP include non-specific immunosuppression (steroids, rituximab), inhibition of platelet clearance (immunoglobulins, splen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b7f4593ede3ca470c693bd8ec511104
https://doi.org/10.1182/blood-2021-150823
https://doi.org/10.1182/blood-2021-150823
Autor:
Kenneth G Campellone, Andrew H. Crosby, Judith D. Brown, Robert N. Jinks, Alyssa J. Mathiowetz, Eric Carrano, Alyssa M Coulter, Ashley J. Russo, Emma L. Baple
Publikováno v:
Molecular Biology of the Cell
The actin assembly machinery coordinates a variety of membrane-remodeling processes. This paper shows that an inherited mutation in the WHAMM gene causes severe defects in autophagy and that the WHAMM protein normally binds to PI(3)P and nucleates ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913e25c83883d336bef1ed145e796570
http://europepmc.org/articles/PMC5597322
http://europepmc.org/articles/PMC5597322
Autor:
Skylar S. Wright, Ashley J. Russo, Sureshkumar Muthupalani, Puja Kumari, Vijay A. K. Rathinam
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 3, Pp 109012-(2021)
Cell Reports, Vol 35, Iss 3, Pp 109012-(2021)
SUMMARY Caspase-11 sensing of intracellular lipopolysaccharide (LPS) plays critical roles during infections and sepsis. However, the key cell types that sense intracellular LPS and their contributions to the host responses at the organismal level are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ca1131c8ac315b275c27792828df7f
http://europepmc.org/articles/PMC8451177
http://europepmc.org/articles/PMC8451177
Publikováno v:
Molecular Biology of the Cell
Small G-proteins regulate the recruitment and activation of WASP-family actin nucleation factors at the plasma membrane. The G-protein Rab1 interacts with the nucleation factor WHAMM to remodel internal membranes into tubules. Unlike other G-proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2260bddd11217e0598ee707484455c0b
http://europepmc.org/articles/PMC4791140
http://europepmc.org/articles/PMC4791140