Výsledky vyhledávání - "Ashley J. Mason"

Akademický článek

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles

Autor: Ashley J. Mason, Austin B. Keeler, Farah Kabir, Bettina Winckler, Christopher Deppmann

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on the distal axons of postganglionic neurons. Upon

Externí odkaz: https://doaj.org/article/6eeab11b19644fb2a5daca8a7e239394

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Emerging Roles of Neuronal Extracellular Vesicles at the Synapse

Autor: Ashley J Mason, Christopher Deppmann, Bettina Winckler

Publikováno v: The Neuroscientist. :107385842311605

Extracellular vesicles (EVs) are secreted from most, if not all, cell types and are implicated in short- and long-distance signaling throughout the body. EVs are also secreted from neurons and represent an emergent neuronal communication platform. Un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b3b422eba9285d22e0c9de6c0888c39
https://doi.org/10.1177/10738584231160521

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'Dynamics and distribution of endosomes and lysosomes in dendrites'

Autor: Chan Choo Yap, Ashley J. Mason, Bettina Winckler

Publikováno v: Curr Opin Neurobiol

All cells are filled with membrane-bound organelles which are responsible for the synthesis and transport as well as degradation of membrane proteins. The localization of these organelles inside cells is highly regulated. The regulation of organelle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e1e9f3308f959cdd18903f4b3a584f
https://europepmc.org/articles/PMC9167696/

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Mice Harboring a Non-Functional CILK1/ICK Allele Fail to Model the Epileptic Phenotype in Patients Carrying Variant CILK1/ICK

Autor: Mark P. Beenhakker, Casey D. Gailey, Eric J. Wang, Ashley J. Mason, Zheng Fu, Kathryn A. Salvati

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8875, p 8875 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16

CILK1 (ciliogenesis associated kinase 1)/ICK (intestinal cell kinase) is a highly conserved protein kinase that regulates primary cilia structure and function. CILK1 mutations cause a wide spectrum of human diseases collectively called ciliopathies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374393361f1c4f49f4be5700c3756216
https://www.mdpi.com/1422-0067/22/16/8875

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Mice Harboring a Non-Functional

Autor: Kathryn A, Salvati, Ashley J, Mason, Casey D, Gailey, Eric J, Wang, Zheng, Fu, Mark P, Beenhakker

Publikováno v: International Journal of Molecular Sciences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bf67b6467a03faa895fb5f8567cb92e
https://pubmed.ncbi.nlm.nih.gov/34445580

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Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion Dependency

Autor: Ashley J Mason, Ravinder Malik, Frank-Gerrit Klärner, Gal Bitan, Irit Sagi, Ian Hurst, Inna Solomonov, Thomas Schrader, Ibrar Siddique

Publikováno v: ACS Chem Neurosci
ACS chemical neuroscience, vol 11, iss 15

Oligomers of amyloid β-protein (Aβ) are thought to be the proximal toxic agents initiating the neuropathologic process in Alzheimer’s disease (AD). Therefore, targeting the self-assembly and oligomerization of Aβ has been an important strategy f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5143ce5d30cde1a67539d4ee739dd844
https://pubmed.ncbi.nlm.nih.gov/32559370

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Preparation of Pure Populations of Amyloid β-Protein Oligomers of Defined Size

Autor: Ashley J Mason, David B. Teplow, Joseph L. Conovaloff, Gal Bitan, Eric Y. Hayden

Publikováno v: Hayden, EY; Conovaloff, JL; Mason, A; Bitan, G; & Teplow, DB. (2018). Preparation of Pure Populations of Amyloid β-Protein Oligomers of Defined Size.. Methods in molecular biology (Clifton, N.J.), 1779, 3-12. doi: 10.1007/978-1-4939-7816-8_1. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7rk5m50r
Methods in Molecular Biology ISBN: 9781493978151

Protein and peptide oligomers are thought to play important roles in the pathogenesis of a number of neurodegenerative diseases. For this reason, considerable effort has been devoted to understanding the oligomerization process and to determining str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5fc70db96974854f13dc20c9a37db80
http://www.escholarship.org/uc/item/7rk5m50r

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Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes

Autor: Ashley J Mason, David B. Teplow, Eric Y. Hayden, Joseph L. Conovaloff, Gal Bitan

Evidence suggests that amyloid β-protein (Aβ) oligomers may be seminal pathogenic agents in Alzheimer's disease (AD). If so, developing oligomer-targeted therapeutics requires an understanding of oligomer structure. This has been difficult due to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b53f843c0b9cf6dd1e7df9ec1e8ead
https://escholarship.org/uc/item/9038v8nv

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Open-close case? New data on appendectomy in an obese patient cohort

Autor: Ashley J Mason, Rodney J. Mason

Publikováno v: Expert review of gastroenterologyhepatology. 7(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254e256bf2a683893f81d1d80ed1d137
https://pubmed.ncbi.nlm.nih.gov/23265142

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