Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase

Autor: Oskar Berntsson, Ralph P. Diensthuber, Matthijs R. Panman, Alexander Björling, Emil Gustavsson, Maria Hoernke, Ashley J. Hughes, Léocadie Henry, Stephan Niebling, Heikki Takala, Janne A. Ihalainen, Gemma Newby, Silke Kerruth, Joachim Heberle, Marianne Liebi, Andreas Menzel, Robert Henning, Irina Kosheleva, Andreas Möglich, Sebastian Westenhoff

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)

Sensor histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction have been proposed. Here the authors present nano- to millisecond time-resolved X-ray scattering measurements, which reveal a

Externí odkaz: https://doaj.org/article/709b281f1d2d49dab68fadc575667aba

Complications of Peripherally Inserted, Large-Bore, Rapid-Infusion Catheters in Orthotopic Liver Transplant Patients

Autor: Colleen T. Ball, Steven B. Porter, Ashley J. Hughes, Tara J. Brigham, Sher-Lu Pai, Karina O. Hex

Publikováno v: Transplantation Proceedings. 53:30-35

Background At our institution, peripherally inserted, 8.5-French rapid-infusion catheters (RICs) are placed for high-flow administration of intravenous fluids and blood products during liver transplant (LT). We sought to estimate the incidence of RIC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412d5a027c5942a95c1f3502566106be
https://doi.org/10.1016/j.transproceed.2020.10.026

Observing the Structural Evolution in the Photodissociation of Diiodomethane with Femtosecond Solution X-Ray Scattering

Autor: Jan Davidsson, Jochen S. Hub, Kasper S. Kjær, Joachim Kübel, Oskar Berntsson, Emil Gustavsson, Matthijs R. Panman, Kalina Atkovska, Martin Nielsen, Diana B. Zederkof, Markus Hermann, Amke Nimmrich, Kensuke Tono, Sebastian Westenhoff, Elisa Biasin, Shigeki Owada, Tetsuo Katayama, Mads G. Laursen, Asmus Ougaard Dohn, Kristoffer Haldrup, Alireza Honarfar, Stephan Niebling, Tim Brandt van Driel, Jens Uhlig, Ashley J. Hughes

Publikováno v: Panman, M R, Biasin, E, Berntsson, O, Hermann, M, Niebling, S, Hughes, A J, Kübel, J, Atkovska, K, Gustavsson, E, Nimmrich, A, Dohn, A O, Laursen, M, Zederkof, D B, Honarfar, A, Tono, K, Katayama, T, Owada, S, Van Driel, T B, Kjær, K, Nielsen, M M, Davidsson, J, Uhlig, J, Haldrup, K, Hub, J S & Westenhoff, S 2020, ' Observing the Structural Evolution in the Photodissociation of Diiodomethane with Femtosecond Solution X-Ray Scattering ', Physical Review Letters, vol. 125, no. 22, 226001 . https://doi.org/10.1103/PhysRevLett.125.226001

Resolving the structural dynamics of the initial steps of chemical reactions is challenging. We report the femtosecond time-resolved wide-angle x-ray scattering of the photodissociation of diiodomethane in cyclohexane. The data reveal with structural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d97ab4eabd39098db535b8bfa66ccc9
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431450

On the (un)coupling of the chromophore, tongue interactions, and overall conformation in a bacterial phytochrome

Autor: Matthijs R. Panman, Stephan Niebling, Heli Lehtivuori, Sebastian Westenhoff, Andreas Menzel, Heikki Takala, Rahul Nanekar, Janne A. Ihalainen, Oskar Berntsson, Léocadie Henry, Ashley J. Hughes

Publikováno v: Journal of Biological Chemistry

Phytochromes are photoreceptors in plants, fungi, and various microorganisms and cycle between metastable red light-absorbing (Pr) and far-red light-absorbing (Pfr) states. Their light responses are thought to follow a conserved structural mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264f544a5cdc187422276073cc4641aa
http://hdl.handle.net/10138/236440

Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism

Autor: Giuliano Siligardi, Timothy R. Rudd, Edwin A. Yates, David G. Fernig, Gareth S. A. Wright, Ashley J. Hughes

Publikováno v: Analytical Methods. 7:1667-1671

Presented herein is a novel method for the detection of tryptophan–ligand interactions utilising magnetic circular dichroism. Two examples are presented, one a small molecule and another, a large polysaccharide, heparan sulfate. These data are also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c180f16ea52b000607e0ce11a4a3fa2
https://doi.org/10.1039/c4ay02618g