Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Ashley J. Fowler"'
1
Pathophysiologic basis for growth failure in children with ichthyosis: An evaluation of cutaneous ultrastructure, epidermal permeability barrier function, and energy expenditure
Autor: Melvin B. Heyman, Debra Crumrine, Ashley J. Fowler, Mary L. Williams, Sharon P. Cohen, Peter M. Elias, David Moskowitz
Publikováno v: The Journal of Pediatrics. 145:82-92
Because an impaired epidermal permeability barrier is present in many of the ichthyoses, we examined the contribution of barrier failure to caloric requirements in children with ichthyosis and growth failure.Transepidermal water loss (TEWL) and ultra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f905f701475a7a7819ae84ce47b83db7
https://doi.org/10.1016/j.jpeds.2004.03.052
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2
Nutritional Status and Gastrointestinal Structure and Function in Children With Ichthyosis and Growth Failure
Autor: Melvin B. Heyman, Ashley J. Fowler, Sharon P. Cohen, Anthony P Wong, Mary L. Williams, David Moskowitz
Publikováno v: Journal of Pediatric Gastroenterology and Nutrition. 38:164-169
UNLABELLED Growth failure occurs in several of the ichthyoses, a heterogeneous group of inherited disorders characterized by thickened or scaly skin. This suggests that there may be common pathogenic mechanisms causing failure to thrive. Previous stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33b5521f7c7dca24fea26fab46dd24e
https://doi.org/10.1097/00005176-200402000-00012
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3
Liver X Receptor Activators Display Anti-Inflammatory Activity in Irritant and Allergic Contact Dermatitis Models: Liver-X-Receptor-Specific Inhibition of Inflammation and Primary Cytokine Production
Autor: Jon L. Collins, Ashley J. Fowler, Jack Kao, David J. Mangelsdorf, Peter M. Elias, Linda D. Rhein, Timothy M. Willson, Kenneth R. Feingold, Mary Y. Sheu, Joachim W. Fluhr, Matthias Schmuth
Publikováno v: Journal of Investigative Dermatology. 120:246-255
Activators of liver X receptors (LXR) stimulate epidermal differentiation and development, but inhibit keratinocyte proliferation. In this study, the anti-inflammatory effects of two oxysterols, 22(R)-hydroxy-cholesterol (22ROH) and 25-hydroxycholest
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cecdbad836df1d618e38396efad6355
https://doi.org/10.1046/j.1523-1747.2003.12033.x
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4
Peroxisome-Proliferator-Activated Receptor (PPAR)-γ Activation Stimulates Keratinocyte Differentiation
Autor: Kenneth R. Feingold, Daniel Metzger, Peggy Lau, Béatrice Desvergne, Walter Wahli, Mei Li, Pierre Chambon, Ashley J. Fowler, Arthur H. Moser, Sandra Chang, Peter M. Elias, Barbara E. Brown, Man Mao-Qiang, Matthias Schmuth, Liliane Michalik
Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2004, 123 (2), pp.305-312. ⟨10.1111/j.0022-202X.2004.23235.x⟩
Previous studies demonstrated that peroxisome-proliferator-activated receptor (PPAR)-alpha or PPAR-delta activation stimulates keratinocyte differentiation, is anti-inflammatory, and improves barrier homeostasis. Here we demonstrate that treatment of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96c3ca0c54860c0fca9b47134d62898
https://hal.archives-ouvertes.fr/hal-03311493
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5
The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease
Autor: Thomas L. Diepgen, Jeffrey L Sugarman, Ashley J. Fowler, Joachim W. Fluhr, Mary L. Williams, Thomas Bruckner
Publikováno v: Archives of dermatology. 139(11)
Objectives Clinical scores used to assess the severity of atopic dermatitis (AD) rely entirely on subjective criteria to evaluate the severity of lesions and the extent of involvement. The aim of this study was to develop an objective measure of AD s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf99c0fc2bade57099886327d13bc47
https://pubmed.ncbi.nlm.nih.gov/14623711
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6
Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities
Autor: Jean-Pierre Hachem, Kenneth R. Feingold, Joachim W. Fluhr, Debra Crumrine, Ashley J. Fowler, Sung Ku Ahn, Barbara E. Brown, Peter M. Elias, Mao-Qiang Man, Jack Kao
Publikováno v: The Journal of investigative dermatology. 120(3)
Prolonged exposure of human epidermis to excess endogenous or exogenous glucocorticoids can result in well-recognized cutaneous abnormalities. Here, we determined whether short-term glucocorticoid treatment would also display adverse effects, specifi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f2e27081e3e528f20fd2a0dcc00ba7
https://pubmed.ncbi.nlm.nih.gov/12603860
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7
Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity
Autor: Ashley J. Fowler, Sarah L. Chamlin, Mary Y. Sheu, Joachim W. Fluhr, Jack Kao, Mary L. Williams, Ilona J. Frieden, Peter M. Elias
Publikováno v: Journal of the American Academy of Dermatology. 47(2)
Background: It is currently fashionable to consider atopic dermatitis (AD), like other inflammatory dermatoses, as immunologic in pathogenesis ("inside-outside" hypothesis). Accordingly, topical glucocorticoids and other immunosuppressive agents are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638ef1790c056e03578f43543def5e10
https://pubmed.ncbi.nlm.nih.gov/12140465
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8
Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models
Autor: Ashley J. Fowler, Jack Kao, Kristina Schoonjans, Kenneth R. Feingold, Mary Y. Sheu, Joachim W. Fluhr, Matthias Schmuth, Johan Auwerx, Peter M. Elias, Mao-Qiang Man
Publikováno v: The Journal of investigative dermatology. 118(1)
Activators of peroxisome proliferator activated receptor-alpha, a nuclear hormone receptor that heterodimerizes with retinoid X receptor, stimulate epidermal differentiation and inhibit proliferation. Here we determined the anti-inflammatory effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bd165178b4c0833e3c0ccf177ef2b7
https://pubmed.ncbi.nlm.nih.gov/11851881
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9
Akademický článek
Nutritional Status and Gastrointestinal Structure and Function in Children With Ichthyosis and Growth Failure.
Autor: Ashley J. Fowler
Publikováno v: Journal of Pediatric Gastroenterology & Nutrition; Feb2004, Vol. 38 Issue 2, p164-169, 6p
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10
Peroxisome Proliferator-Activated Receptor (PPAR)-β/δ Stimulates Differentiation and Lipid Accumulation in Keratinocytes
Autor: Johan Auwerx, Sandra Chang, Sheri T. Dorsam, Peggy Lau, Julie C. Holder, Man Mao-Qiang, William Cairns, Timothy M. Willson, Arthur H. Moser, Gary Chuang, Matthias Schmuth, Christopher M. Haqq, Pierre Chambon, Barbara E. Brown, Yoshikazu Uchida, Kenneth R. Feingold, Peter M. Elias, Ashley J. Fowler, Kristina Schoonjans
Publikováno v: Journal of Investigative Dermatology. (4):971-983
Peroxisome proliferator-activated receptor (PPAR) are nuclear hormone receptors that are activated by endogenous lipid metabolites. Previous studies have demonstrated that PPAR-alpha activation stimulates keratinocyte differentiation in vitro and in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b865caf221ad985704127d9c496d22
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