Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

Autor: Jineet Patel, Lori L. Wallrath, Ashley J. Earle, Sushruta Iruvanti, Gisèle Bonne, Philipp Isermann, Steven A. Moore, Jan Lammerding, Tyler J. Kirby, Gregory R. Fedorchak

Publikováno v: Earle*, A J, Kirby*, T J, Fedorchak*, G R, Isermann, P, Patel, J, Iruvanti, S, Moore, S A, Bonne, G, Wallrath, L L & Lammerding, J 2020, ' Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells ', Nat. Mater., vol. 19, no. 4, pp. 464-473 . https://doi.org/10.1038/s41563-019-0563-5
Nat. Mater., 19(4), 464-473. Nature Publishing Group

Mutations in the humanLMNAgene, which encodes the nuclear envelope (NE) proteins lamins A and C, cause autosomal dominant Emery-Dreifuss muscular dystrophy, congenital muscular dystrophy, limb-girdle muscular dystrophy, and other diseases collectivel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf77a48c7ed2a7d77b10340b26d83c6
https://research.vumc.nl/en/publications/cbecc6fd-0a34-4eb7-a64e-dc16d005b5e5

Lamin A/C Mutations Linked to Muscular Disease Result in Mechanically‐induced, Progressive Nuclear Envelope Rupture and DNA Damage in Muscle Fibers

Autor: Jan Lammerding, Ashley J. Earle, Philipp Isermann, Greg Fedorchak, Tyler J. Kirby

Publikováno v: The FASEB Journal. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd262141f70a01e15e84bc6ecbf93dc9
https://doi.org/10.1096/fasebj.2018.32.1_supplement.816.6