Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ashley J. Clark"'
Autor:
Ashley J. Clark, Niamh Mullooly, Dewi Safitri, Matthew Harris, Tessa de Vries, Antoinette MaassenVanDenBrink, David R. Poyner, Davide Gianni, Mark Wigglesworth, Graham Ladds
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Clark et al. explore the ability of ligands to activate the calcitonin-like receptor (CLR) in primary endothelial cells, and the influence of co-expressed receptor-activity modifying proteins (RAMPs). Their study reveals that GPCR agonist bias occurs
Externí odkaz:
https://doaj.org/article/750a5c1d0a384cd190361d11fbf63d68
Autor:
Matthew Harris, Davide Gianni, David R. Poyner, Tessa de Vries, Niamh Mullooly, Antoinette MaassenVanDenBrink, Dewi Safitri, Ashley J. Clark, Graham Ladds, Mark Wigglesworth
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology, 4(1):776. Springer Nature
Communications Biology
Communications Biology, 4(1):776. Springer Nature
Agonist bias occurs when different ligands produce distinct signalling outputs when acting at the same receptor. However, its physiological relevance is not always clear. Using primary human cells and gene editing techniques, we demonstrate endogenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3145229e06f03916f885bb8f59e261
https://www.repository.cam.ac.uk/handle/1810/322519
https://www.repository.cam.ac.uk/handle/1810/322519
Autor:
Davide Giani, Niamh Mullooly, Tessa de Vries, Mark Wigglesworth, Graham Ladds, Antoinette Maassen van den Brink, Matthew Harris, David R. Poyner, Dewi Safitri, Ashley J. Clark
Agonist bias at G protein-coupled receptors has attracted considerable interest, although its relevance for physiologically-produced agonists is not always clear. Here, using primary human cells and gene editing techniques, we demonstrate for the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c9847a2a490bd2f0d68dd3f07cabbf9
https://doi.org/10.1101/2020.12.21.423730
https://doi.org/10.1101/2020.12.21.423730
Autor:
Sarah J Routledge, Ho Yan Yeung, David R. Poyner, John Simms, Graham Ladds, Ashley J. Clark, Philip Kitchen, Ian M. Dickerson, Mark Wigglesworth
Publikováno v:
Biochimica et Biophysica Acta. Biomembranes
Receptor component protein (RCP) is a 148 amino acid intracellular peripheral membrane protein, previously identified as promoting the coupling of CGRP to cAMP production at the CGRP receptor, a heterodimer of calcitonin receptor like-receptor (CLR),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236da83f7c1d6247f84d923e137aa25d
https://publications.aston.ac.uk/id/eprint/41020/1/endogenous_allosteric_modulator.pdf
https://publications.aston.ac.uk/id/eprint/41020/1/endogenous_allosteric_modulator.pdf