Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Ashley J Snider"'
Autor:
Fabiola N Velazquez, Leiqing Zhang, Valentina Viscardi, Carolena Trocchia, Yusuf A Hannun, Lina M Obeid, Ashley J Snider
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0252311 (2021)
Breast cancer is a very heterogeneous disease, and ~30% of breast cancer patients succumb to metastasis, highlighting the need to understand the mechanisms of breast cancer progression in order to identify new molecular targets for treatment. Sphingo
Externí odkaz:
https://doaj.org/article/82365634bb0c4285b6c0179117fab065
Autor:
Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z Gong, Chet Preston, Louis Wang, Jae Kyo Yi, Chih-Li Lin, Wei Sun, Demetri D Spyropoulos, Soyoung Rhee, Mingsong Li, Jie Zhou, Shaoyu Ge, Guofeng Zhang, Ashley J Snider, Yusuf A Hannun, Lina M Obeid, Cungui Mao
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007190 (2018)
[This corrects the article DOI: 10.1371/journal.pgen.1005591.].
Externí odkaz:
https://doaj.org/article/45d068c61fea488ba04dc8acda9d4cb3
Autor:
Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z Gong, Chet Preston, Louis Wang, Jae Kyo Yi, Chih-Li Lin, Wei Sun, Demetri D Spyropoulos, Soyoung Rhee, Mingsong Li, Jie Zhou, Shaoyu Ge, Guofeng Zhang, Ashley J Snider, Yusuf A Hannun, Lina M Obeid, Cungui Mao
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005591 (2015)
Dyshomeostasis of both ceramides and sphingosine-1-phosphate (S1P) in the brain has been implicated in aging-associated neurodegenerative disorders in humans. However, mechanisms that maintain the homeostasis of these bioactive sphingolipids in the b
Externí odkaz:
https://doaj.org/article/695385deccaf4cf6af0ae32e53b1b903
Autor:
Amr M Ghaleb, Agnieszka B Bialkowska, Ashley J Snider, Dmitri V Gnatenko, Yusuf A Hannun, Vincent W Yang, Valentina A Schmidt
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129314 (2015)
IQ motif-containing GTPase-activating protein 2 (IQGAP2) is a multidomain scaffolding protein that plays a role in cytoskeleton regulation by juxtaposing Rho GTPase and Ca2+/calmodulin signals. While IQGAP2 suppresses tumorigenesis in liver, its role
Externí odkaz:
https://doaj.org/article/e1e963824a714414990feb147a2811a1
Autor:
Ashley J Snider, Wahida H Ali, Jonathan A Sticca, Nicolas Coant, Amr M Ghaleb, Toshihiko Kawamori, Vincent W Yang, Yusuf A Hannun, Lina M Obeid
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113998 (2014)
Sphingosine kinase 1 (SK1), one of two SK enzymes, is highly regulated and has been shown to act as a focal point for the action of many growth factors and cytokines. SK1 leads to generation of sphingosine-1-phosphate (S1P) and potentially the activa
Externí odkaz:
https://doaj.org/article/ee8575fa4dc74a55a293c690bc7704c7
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53521 (2013)
Sphingosine-1-phosphate (S1P), a potent bioactive lipid, is emerging as a central mediator in inflammation and immune responses. We have previously implicated S1P and its synthetic enzyme sphingosine kinase (SK) in inflammatory and autoimmune disorde
Externí odkaz:
https://doaj.org/article/1f4ddb90b4504442a8189b093bd7adae
Autor:
María José Hernández-Corbacho, Russell W Jenkins, Christopher J Clarke, Yusuf A Hannun, Lina M Obeid, Ashley J Snider, Leah J Siskind
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20411 (2011)
Chronic kidney disease and end-stage renal disease are major causes of morbidity and mortality that are seen far more commonly in the aged population. Interestingly, kidney function declines during aging even in the absence of underlying renal diseas
Externí odkaz:
https://doaj.org/article/34e52c6f70c34e768e42ea78d6c6feea
Autor:
Keila S. Espinoza, Ashley J. Snider
Publikováno v:
Cancers, Vol 16, Iss 4, p 789 (2024)
Inflammatory bowel disease (IBD), characterized by chronic inflammation in the intestinal tract, increases the risk for the development of colorectal cancer (CRC). Sphingolipids, which have been implicated in IBD and CRC, are a class of bioactive lip
Externí odkaz:
https://doaj.org/article/951e99717f484f7a90e44ac9c0670278
Autor:
Ashley J. Snider, Yusuf A. Hannun, Rasheed Ahmad, Zunair Ahmad, Motasem Melhem, Fahd Al-Mulla, Fatema Al-Rashed, Lina M. Obeid, Reeby Thomas
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Obesity is associated with elevated levels of TNF-α and proinflammatory CD11c monocytes /macrophages. TNF-α mediated dysregulation in the plasticity of monocytes/macrophages is concomitant with pathogenesis of several inflammatory diseases, includi
Autor:
Ashley J. Snider, Emily Montal, Jean-Philip Truman, Cungui Mao, Christian F. Ruiz, Izolda Mileva, Yusuf A. Hannun, Lina M. Obeid, Monica Garcia-Barros
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100154-(2022)
Cancer cells can become dependent on exogenous serine, depletion of which results in slower growth and activation of a number of adaptive metabolic changes. We previously demonstrated that serine and glycine (SG) deprivation causes loss of sphingosin