Tumor Evolution and Intratumor Heterogeneity of an Oropharyngeal Squamous Cell Carcinoma Revealed by Whole-Genome Sequencing

Autor: Xinyi Cindy Zhang, Chang Xu, Ryan M. Mitchell, Bo Zhang, Derek Zhao, Yao Li, Xin Huang, Wenhong Fan, Hongwei Wang, Luisa Angelica Lerma, Melissa P. Upton, Ashley Hay, Eduardo Méndez, Lue Ping Zhao

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 12, Pp 1371-1378 (2013)

Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genomic instability that could lead to sclonal diversity. Intratumor clonal heterogeneity has been proposed as a major attribute underlying tumor evolution, progression, an

Externí odkaz: https://doaj.org/article/a38975bca6034311b68cfc8f28188aa8

Longitudinal measurement of HPV copy number in cell-free DNA is associated with patient outcomes in HPV-positive oropharyngeal cancer

Autor: Sophie J. Warlow, Martyna Adamowicz, John P. Thomson, Robert A. Wescott, Christelle Robert, Lara M. Carey, Helen Thain, Kate Cuschieri, Lucy Q. Li, Brendan Conn, Ashley Hay, Iain J. Nixon, Timothy J. Aitman

Publikováno v: Warlow, S J, Adamowicz, M, Thomson, J P, Wescott, R A, Robert, C, Carey, L M, Thain, H, Cuschieri, K, Li, L Q, Conn, B, Hay, A, Nixon, I J & Aitman, T J 2022, ' Longitudinal measurement of HPV copy number in cell-free DNA is associated with patient outcomes in HPV-positive oropharyngeal cancer ', EJSO-European Journal of Surgical Oncology, vol. 48, no. 6, pp. 1224-1234 . https://doi.org/10.1016/j.ejso.2022.03.232

INTRODUCTION: Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in global prevalence and is divided into two types dependent on association with human papillomavirus (HPV). Assay of HPV copy number in plasma cell-free DNA (cfDNA) provides a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb22709f9741575b7775798e5f4cfa4
https://doi.org/10.1016/j.ejso.2022.03.232

A UK based two-centre review of multifocality and its role in the treatment of papillary thyroid cancer

Autor: Richard Adamson, Ashley Hay, Shi Ying Hey, Ricard Simo, Chrysostomos Tornari, Rupali Sawant, Lucy Li, Noah Evans Harding, Iain J. Nixon, Daria Andreeva

Publikováno v: Qian Li, L, Ying Hey, S, Andreeva, D, Tornari, C, Sawant, R, Evans Harding, N, Adamson, R, Hay, A, Simo, R & Nixon, I 2021, ' A UK based two-centre review of multifocality and its role in the treatment of papillary thyroid cancer ', EJSO-European Journal of Surgical Oncology . https://doi.org/10.1016/j.ejso.2021.06.033

Introduction Multifocality is increasingly observed in papillary thyroid carcinoma (PTC) due to improvements in imaging and histopathological analysis. However, its significance in management, particularly as a sole risk-factor, remains controversial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76ee42beecfcac964ef8f7e042838ab
https://doi.org/10.1016/j.ejso.2021.06.033

Active surveillance for PTMC warranted for the UK population?

Autor: Pavithran Maniam, Noah Harding, Lucy Li, Richard Adamson, Ashley Hay, Ian Nixon

Publikováno v: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-LaryngologyCervico-Facial SurgeryREFERENCES. 48(1)

The incidence of thyroid cancer is increasing globally due to the increase in detection of subclinical, low volume papillary thyroid microcarcinomas (PTMC) (1 cm). Several international groups have recommended an active surveillance approach for this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b767687a8fa45fac9bad598b28777f
https://pubmed.ncbi.nlm.nih.gov/36183341

Clinicopathological features of Differentiated Thyroid Cancer presenting in the UK versus internationally: An observational cohort study

Autor: Fraser W. Gibb, Rupali Sawant, Richard Adamson, Shi Ying Hey, Iain J. Nixon, Ashley Hay, K Hulse

Publikováno v: Clinical Otolaryngology. 46:522-529

Introduction Very little data is available regarding differentiated thyroid cancer (DTC) managed in the UK, and no UK patients are included in the evidence base upon which international guidelines are based. Therefore, the aim of this study was to co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ab74443f956836e6c8ba00167dfb9d
https://doi.org/10.1111/coa.13699