Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Ashley Goss"'
1
Cardiovascular risk prediction model and stratification in patients with type 2 diabetes enrolled in a Medicare Advantage plan
Autor: Vinay Chiguluri, Raymond A. Harvey, Michael W. Kattan, Todd Prewitt, Pratik Pimple, Eleanor O. Caplan, Ashley Goss, Jennifer Hayden, Rakesh Luthra
Publikováno v: Journal of Managed Care & Specialty Pharmacy. 27:1579-1591
BACKGROUND: Cardiovascular (CV) risk tools have been developed both nationally and internationally to identify patients at risk for developing CV disease or experiencing a CV event. However, these tools vary widely in the definitions of endpoints, th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16fa8ec6ba40f0e4e1f25d23b53c498
https://doi.org/10.18553/jmcp.2021.27.11.1579
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2
404-P: Cardiovascular Risk Scoring and Stratification in Patients with Type 2 Diabetes Enrolled in a Medicare Advantage Plan
Autor: Rakesh Luthra, Pratik Pimple, Ashley Goss, Todd Prewitt, Jennifer Hayden, Vinay Chiguluri, Raymond A. Harvey, Eleanor O. Caplan, Michael W. Kattan
Publikováno v: Diabetes. 69
Current tools to identify patients at risk for cardiovascular (CV) disease or events are variable, limiting their utility and generalizability. The purpose of this study was to develop a predictive model to identify patients with type 2 diabetes (T2D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff51cf51bdd12b3be7065c65f86eac59
https://doi.org/10.2337/db20-404-p
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3
Thrombin promotes diet-induced obesity through fibrin-driven inflammation
Autor: Hartmut Weiler, A. Phillip Owens, Matthew J. Flick, Ashley Goss, Joanne van Ryn, Joseph S. Palumbo, Senad Divanovic, Sara R. Abrahams, Eric S. Mullins, Anna K. Kopec, Nigel Mackman, James P. Luyendyk, Sherry Thornton
Publikováno v: Journal of Clinical Investigation. 127:3152-3166
Obesity promotes a chronic inflammatory and hypercoagulable state that drives cardiovascular disease, type 2 diabetes, fatty liver disease, and several cancers. Elevated thrombin activity underlies obesity-linked thromboembolic events, but the mechan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2209ba95d0873da77f908287e964e8da
https://doi.org/10.1172/jci92744
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4
The effect of ultrafiltration with cardiopulmonary bypass on the removal of dabigatran from the circulation of adult pigs
Autor: Rupak Mukherjee, Alicia Sievert, John M. Toole, Walter E. Uber, Walter F. DeNino, Christopher B. Carter, Ashley Goss
Publikováno v: Perfusion. 31:424-430
Objective: Dabigatran etexilate is a direct thrombin inhibitor approved for use in patients with non-valvular atrial fibrillation. There is no currently available pharmacological therapy to reverse this renally cleared anticoagulant. Dabigatran has a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069fd825db77a29e6fb2408c304708a6
https://doi.org/10.1177/0267659115614640
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5
Characterization of Thrombin-Bound Dabigatran Effects on Protease-Activated Receptor-1 Expression and Signaling In Vitro
Autor: Antonio G. Soto, Luisa J. Coronel, Buxin Chen, Ashley Goss, Joanne van Ryn, JoAnn Trejo
Publikováno v: Molecular pharmacology, vol 88, iss 1
Thrombin, the key effector protease of the coagulation cascade, drives fibrin deposition and activates human platelets through protease-activated receptor-1 (PAR1). These processes are critical to the progression of thrombotic diseases. Thrombin is t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2595fe962f7d43f5eed707e313f34bc2
https://europepmc.org/articles/PMC4468637/
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7
The Discovery of Dabigatran Etexilate
Autor: Ashley Goss, Herbert Nar, Andreas Clemens, Joanne van Ryn, Wolfgang Wienen, Norbert Hauel, Henning Priepke
Publikováno v: Analogue-Based Drug Discovery III
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 4 (2013)
Thromboembolic disease is a major cause of mortality and morbidity in the developed world and is caused by an excessive stimulation of coagulation. Thrombin is a key serine protease in the coagulation cascade and numerous efforts have been made to de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe3f64a56dea230d27ec112664d4cb3
https://doi.org/10.3389/fphar.2013.00012
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8
Abstract 392: Synergistic anti-tumor effects of dabigatran etexilate and cyclophosphamide co-treatment are associated with decreased circulating tissue factor positive microparticles
Autor: Joanne van Ryn, Candace S. Hayes, Susan K. Gilmour, Allyson R. Minton, Eric T. Alexander, Ashley Goss
Publikováno v: Cancer Research. 75:392-392
Introduction: Coagulation proteases and the generation of thrombin are increased in tumors. The incidence of cancer-associated thromboses is also increased by treatment with chemotherapeutic agents commonly used to treat malignant cancers. Thrombin c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c653c8f040f41f13823cbb118ad1ebc
https://doi.org/10.1158/1538-7445.am2015-392
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9
Assessment of Cross-Reactivity in Three Different Fecal Occult Blood Test Systems with Dabigatran and Dabigatran Etexilate: Identification of Useful Test Methods
Autor: Joanne van Ryn, Ashley Goss, Andreas Clemens, Johanna Schurer
Publikováno v: Blood. 120:4360-4360
Abstract 4360 Anticoagulant therapy can elevate the risk of gastrointestinal (GI) bleeding and may affect its management. Fecal occult blood tests (FOBT) are non-invasive, widely-used tests that may be useful in detecting early and thus treatable sta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d58ff7bfc5814bca4aaf86ba3d4b496e
https://doi.org/10.1182/blood.v120.21.4360.4360
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