Výsledky vyhledávání - "Ashley Francois"

Autor: Lynn Marcho, Matthew S. Stratton, Ashley Francois, Alessandro Canella

Publikováno v: J Mol Cell Cardiol

Biological aging is attributed to progressive dysfunction in systems governing genetic and metabolic integrity. At the cellular level, aging is evident by accumulated DNA damage and mutation, reactive oxygen species, alternate lipid and protein modif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bccd4ff5dae9a194435c779a2100c9
https://doi.org/10.1016/j.yjmcc.2021.04.007

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Molecular signature of cardiac remodeling associated with Polymerase Gamma mutation

Autor: Matthew W. Gorr, Ashley Francois, Lynn M. Marcho, Ty Saldana, Erin McGrail, Nuo Sun, Matthew S. Stratton

Publikováno v: Life Sci

AIMS: Metabolic function/dysfunction is central to aging biology. This is well illustrated by the Polymerase Gamma (POLG) mutant mouse where a key residue of the mitochondrial DNA polymerase is mutated (D257A), causing loss of mitochondrial DNA stabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a094d907c7819ffd946d458d96e7d27
https://europepmc.org/articles/PMC9158136/

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Molecular signature of RV cardiac remodeling associated with Polymerase Gamma mutation

Autor: Matthew W. Gorr, Ashley Francois, Lynn M. Marcho, Ty Saldana, Erin McGrail, Nuo Sun, Matthew S. Stratton

Aging is associated with metabolic dysfunction and metabolic dysfunction accelerates the course of aging. This is well illustrated by aging-like phenotypes displayed in the Polymerase Gamma mutant mouse. Here, a key residue of the mitochondrial DNA p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe772e704da4f7305a795d5d56d50613
https://doi.org/10.1101/2022.02.11.480145

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Black In Cardio: promoting diversity and representation in the cardiovascular field

Autor: Jason Amartey, Chichi Okagbue, Adama Saccoh, Stanley Buffonge, Ashley Francois, Catherine Tcheandjieu, Shaneice Mitchell, Daniel J. Tyrrell, Debora Kamin Mukaz

Publikováno v: Nat Rev Cardiol

Globally, Black people have some of the highest rates of cardiovascular disease. Racial inequities in cardiovascular health must be tackled. Black In Cardio is a trainee-led initiative aimed at promoting Black people in the cardiovascular field and r

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https://doi.org/10.1038/s41569-022-00774-x

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Abstract MP259: The Role Of Sertad4 In Pathological Cardiac Remodeling

Autor: Federica Accornero, Alessandro Canella, Erin McGrail, Lynn Marcho, Bryan A. Whitson, Richard J. Gumina, Shamama Nishat, Matthew S. Stratton, Ashley Francois, Oscar Bermeo-Blanco, Paul M.L. Janssen

Publikováno v: Circulation Research. 129

Over 6 million Americans suffer from heart failure (HF) while the 5-year mortality rate following first admission for HF is over 40%. Cardiac fibrosis is a clinical hallmark of HF, regardless of the initiating pathology and is thought to contribute t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28d448873b7ab67c21bb0c3e5acc0c2e
https://doi.org/10.1161/res.129.suppl_1.mp259

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